Plastic collapse strength and maximum load evaluation method of flawed stainless piping subjected to axial tension and bending

Yanagihara, Seiji*; Matsubara, Masaaki*; Suzuki, Ryosuke*; Suzuki, Masato*; Shiraishi, Taisuke*; Sakamoto, Kenji*; Wakai, Takashi

Nihon Kikai Gakkai M&M 2012 Zairyo Rikigaku Kanfarensu Koen Rombunshu (CD-ROM), 2 Pages, 2012/09

Collapse strength of multiple notched pipes under combined load

Shiraishi, Taisuke*; Matsubara, Masaaki*; Suzuki, Ryosuke*; Suzuki, Masato*; Wakai, Takashi; Sakamoto, Kenji*

Proceedings of 5th International Workshop New Methods of Damage and Failure Analysis of Structural Parts (CD-ROM), 6 Pages, 2012/09

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness

Ito, Takachika*; Suzuki, Shoichi*; Kanaji, Sachiko*; Shiraishi, Hiroshi*; Ota, Shoichiro*; Arima, Kazuhiko*; Tanaka, Go*; Tamada, Taro; Honjo, Eijiro*; Garcia, K. C.*; et al.

Journal of Biological Chemistry, 284(36), p.24289 - 24296, 2009/09

https://doi.org/10.1074/jbc.M109.007286

Both IL-4 and IL-13 can bind to the shared receptor composed of the IL-4 receptor chain and the IL-13 receptor -1 chain (IL-13R1); however, the assembly mechanisms of these ligands to the receptor is different, enabling the principal functions of these ligands to be different. We have previously shown that the N-terminal Ig-like domain in IL-13R1, called the D1 domain, is the specific and critical binding unit for IL-13. However, it has still remained obscure which the amino acid has specific binding capacity to IL-13 and why the D1 domain acts as the binding site for IL-13, but not IL-4. To address these questions, in this study, we performed the mutational analyses for the D1 domain, combining the structural data to identify the amino acids critical for binding to IL-13. Mutations of Lys76, Lys77, or Ile78 in c' strand in which the crystal structure showed interact with IL-13 and those of Trp65 and Ala79 adjacent to the interacting site, resulted in significant impairment of IL-13 binding, demonstrating that these amino acids generate the binding site. Furthermore, mutations of Val35, Leu38, or Val42 at N-terminal -strand also resulted in loss of IL-13 binding, probably from decrease structural stability. None of the mutations employed here affected IL-4 binding. These results demonstrate that the hydrophobic patch composed of Lys76, Lys77, and Ile78 is the IL-13 recognition site and solidify our understanding that the differential requirements of the D1 domain in IL-13R1 allows the shared receptor to respond differentially to IL-4 and IL-13.

Comprehensive cost estimation method for decommissioning

Kudo, Kenji; Kawatsuma, Shinji; Rindo, Hiroshi; Watabe, Kozo; Tomii, Hiroyuki; Shiraishi, Kunio; Yagi, Naoto; Fukushima, Tadashi; Zaitsu, Tomohisa

Proceedings of 14th International Conference on Nuclear Engineering (ICONE-14) (CD-ROM), 8 Pages, 2006/07

Japan Atomic Energy Research Institute (JAERI) played a leading role in basic research in the field of atomic energy research and development, while Japan Nuclear Cycle Development Institute (JNC) did a major role in FBR cycle development and high level waste disposal. Following the Government's decision in December 2001, JAERI and JNC was merged as of October 1st, 2005. The new organization, Japan Atomic Energy Agency (JAEA), is an institute for comprehensive R&D for atomic energy, and is the largest research and development institute among Governmental R&D organizations. Its missions are basic research on atomic energy, R&D for nuclear fuel cycle, decommissioning of own facilities and disposal of waste, contribution to safety and non-proliferation, etc. The JAEA owns a number of nuclear facilities: research reactors such as JRR-2 and Joyo, prototype reactors such as ATR "Fugen" and FBR "Monju", fuel cycle plants such as Uranium Enrichment Demonstration Plant at Ningyo-Toge, MOX fuel plants at Tokai, Reprocessing Plant at Tokai, and Hot Laboratories such as JRTF and FMF. As a part of preparation of the mergence, JNC and JAERI have jointly developed a comprehensive cost estimation method for decommissioning, based on decommissioning and refurbishing experiences of JAERI and JNC. This method involves more estimation parameters from typical decommissioning activities than before, so as to make it more reliable. JAERI and JNC have estimated the total cost for decommissioning by using this method, and concluded that the cost would be 600 billion yen (approx. 5 billion USD).

Bandgaps of GaInN by all-electron GWA calculation

Usuda, Manabu; Hamada, Noriaki*; Shiraishi, Kenji*; Oshiyama, Atsushi*

Physica Status Solidi (C), 0(7), p.2733 - 2736, 2003/12

https://doi.org/10.1002/pssc.200303278

The electronic band-structures of wurtzite-type GaInN are calculated by using an all-electron FLAPW method in the approximation(GWA). Our calculations show that the bandgap of InN is smaller than 1 eV, and strongly support the recently observed smaller bandgaps.