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Kataoka, Takahiro*; Shuto, Hina*; Naoe, Shota*; Yano, Junki*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Hanamoto, Katsumi*; Mitsunobu, Fumihiro*; Terato, Hiroaki*; et al.
Journal of Radiation Research (Internet), 62(5), p.861 - 867, 2021/09
Times Cited Count:5 Percentile:55.27(Biology)Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Shuto, Hina*; Yano, Junki*; Naoe, Shota*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.
Journal of Radiation Research (Internet), 62(2), p.206 - 216, 2021/03
Times Cited Count:6 Percentile:61.83(Biology)Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation. Mice inhaled radon at concentrations of 2 or 20 kBq/m for 1, 3, or 10 days. The relationship between antioxidative function and oxidative stress was evaluated by principal component analysis (PCA) and correlation coefficient compared with control mice subjected to sham inhalation. These findings suggested that radon inhalation altered the redox state in organs, but that the characteristics varied depending on the redox state in organs.
Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Ishida, Tsuyoshi; Shuto, Hina*; Yano, Junki*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.
no journal, ,
We have reported that radon inhalation activates antioxidative functions in mouse organs. These activation inhibits reactive oxygen species (ROS) induced oxidative stresses. Activation of antioxidative functions induced by radon inhalation probably due to the production of a small quantity of ROS. However, there were no reports on this mechanism. In this study, we evaluated hydrogen peroxide induced oxidative stress by radon inhalation in mouse organs. That is, mice inhaled radon at a concentration of 1 kBq/m or 10 kBq/m for 24 hours. Results showed that radon inhalation increased hydrogen peroxide in liver and lung by 20%. On the other hand, hydrogen peroxide in heart decreased by 20%. This is probably due to total glutathione reacts with hydrogen peroxide. These findings suggest that radon inhalation produces a small quantity of hydrogen peroxide, which is ROS, in mouse organs. However, antioxidative related substances, which are catalase and total glutathione, play an important role to reduce oxidative stress.
Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Ishida, Tsuyoshi; Shuto, Hina*; Yano, Junki*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.
no journal, ,
no abstracts in English
Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Shuto, Hina*; Yano, Junki*; Ishida, Tsuyoshi*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.
no journal, ,
no abstracts in English
Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Shuto, Hina*; Yano, Junki*; Naoe, Shota*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.
no journal, ,
no abstracts in English
Masukawa, Yuki*; Kataoka, Takahiro*; Shuto, Hina*; Naoe, Shota*; Yano, Junki*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Hanamoto, Katsumi*; Mitsunobu, Fumihiro*; et al.
no journal, ,
no abstracts in English
Nishi, Soyoka*; Kataoka, Takahiro*; Ishida, Tsuyoshi*; Naoe, Shota*; Shuto, Hina*; Yano, Junki*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Mitsunobu, Fumihiro*; et al.
no journal, ,
no abstracts in English
Naoe, Shota*; Kataoka, Takahiro*; Yano, Junki*; Shuto, Hina*; Kanzaki, Norie; Sakoda, Akihiro; Yamaoka, Kiyonori*
no journal, ,
no abstracts in English