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Journal Articles

Electron-tracking Compton camera imaging of technetium-95m

Hatsukawa, Yuichi*; Hayakawa, Takehito*; Tsukada, Kazuaki; Hashimoto, Kazuyuki*; Sato, Tetsuya; Asai, Masato; Toyoshima, Atsushi; Tanimori, Toru*; Sonoda, Shinya*; Kabuki, Shigeto*; et al.

PLOS ONE (Internet), 13(12), p.e0208909_1 - e0208909_12, 2018/12

AA2018-0639.pdf:2.39MB

 Times Cited Count:3 Percentile:27.63(Multidisciplinary Sciences)

Imaging of $$^{95m}$$Tc radioisotope was conducted using an electron tracking-Compton camera (ETCC). $$^{95m}$$Tc emits 204, 582, and 835 keV $$gamma$$ rays, and was produced in the $$^{95}$$Mo(p,n)$$^{95m}$$Tc reaction with a $$^{95}$$Mo-enriched target. The recycling of the $$^{95}$$Mo-enriched molybdenum trioxide was investigated, and the recycled yield of $$^{95}$$Mo was achieved to be 70% - 90%. The images were obtained with each of the three $$gamma$$ rays. Results showed that the spatial resolution increases with increasing $$gamma$$-ray energy, and suggested that the ETCC with high-energy $$gamma$$-ray emitters such as $$^{95m}$$Tc is useful for the medical imaging of deep tissue and organs in the human body.

Journal Articles

Production of $$^{rm 95m}$$Tc for Compton camera imaging

Hatsukawa, Yuichi; Hashimoto, Kazuyuki; Tsukada, Kazuaki; Sato, Tetsuya; Asai, Masato; Toyoshima, Atsushi; Nagai, Yasuki; Tanimori, Toru*; Sonoda, Shinya*; Kabuki, Shigeto*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 303(2), p.1283 - 1285, 2015/02

 Times Cited Count:2 Percentile:16.69(Chemistry, Analytical)

Technetium-99m ($$^{rm 99m}$$Tc) is used in radioactive medical diagonostic tests, for example as a radioactive tracer that medical equipment can detect in the human body. It is well suited to the role because it emits readily detectable 141 keV $$gamma$$ rays, and its half-life is 6.01 hours (meaning that about 94% of it decays to technetium-99 in 24 hours). There are at least 31 commonly used radiopharmaceuticals based on technetium-99m for imaging and functional studies of the brain, myocardium, thyroid, lungs, liver, gallbladder, kidneys, skeleton, blood, and tumors. Recent years, with the develop-ment of the Compton camera which can realize high position resolution, technetium isotopes emitting high energy $$gamma$$-rays are required. In this study, technetium-95m which emits some $$gamma$$ rays around 800 keV was produced by the $$^{95}$$Mo(p,n)$$^{rm 95m}$$Tc reaction.

Journal Articles

X-ray study of radiation damage in UO$$_{2}$$ irradiated with high-energy heavy ions

Ishikawa, Norito; Sonoda, Takeshi*; Okamoto, Yoshihiro; Sawabe, Takashi*; Takegahara, Keisuke; Kosugi, Shinya*; Iwase, Akihiro*

Journal of Nuclear Materials, 419(1-3), p.392 - 396, 2011/12

 Times Cited Count:11 Percentile:62.72(Materials Science, Multidisciplinary)

In order to characterize the radiation damage due to ion-track formation in UO$$_{2}$$, polycrystalline samples have been irradiated with 210-MeV Xe ions, and measured with XRD (X-ray diffraction) technique using Cu X-ray. We have also tried EXAFS (extended X-ray absorption fine structure) measurement using X-ray near U L$$_{3}$$-edge. The results show that XRD technique detects damage at relatively low fluence of 10$$^{16}$$ ions/m$$^{2}$$ and higher, while the irradiation-induced change of EXAFS spectra is not observed even at highest fluence of 10$$^{19}$$ ions/m$$^{2}$$. The damage detection may be critically influenced by the depth profile of X-ray penetration.

Oral presentation

Imaging test of the gamma-ray distribution in the reactor room using electron-tracking Compton camera (ETCC)

Sonoda, Shinya*; Takada, Atsushi*; Tanimori, Toru*; Tsuda, Masaya*; Tahara, Keisuke*; Kobayashi, Koichiro*; Tanigaki, Minoru*; Nagai, Haruyasu; Nakayama, Hiromasa; Satoh, Daiki

no journal, , 

We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays. Here, we present the results of the gamma-imaging-spectroscopy with ETCC tested at the research reactor at the Institute for Integrated Radiation and Nuclear Science, Kyoto University.

Oral presentation

The Performance evaluation of electron tracking Compton camera for medical imaging

Sonoda, Shinya*; Nabetani, Akira*; Kimura, Hiroyuki*; Kabuki, Shigeto*; Takada, Atsushi*; Kubo, Hidetoshi*; Kimura, Shotaro*; Sawano, Tatsuya*; Tanimori, Toru*; Matsuoka, Yoshihiro*; et al.

no journal, , 

We have developed the ETCC for new medical imaging device and succeeded in imaging the some medical imaging reagents. Thus, this detector is thought promising for a new medical imaging. The F-18 point-like and rod-like phantoms are measured with new ETCC, and the imaging performance was estimated. In addition, measurement of Tc-95m which is produced by Japan Atomic Energy Agency was performed.

Oral presentation

Application of Electron Tracking Compton Camera (ETCC) in medical imaging

Sonoda, Shinya*; Nabeya, Akira*; Kimura, Hiroyuki*; Kabuki, Shigeto*; Takada, Atsushi*; Kubo, Hidetoshi*; Komura, Shotaro*; Tanimori, Toru*; Matsuoka, Yoshihiro*; Mizumura, Yoshitaka*; et al.

no journal, , 

SPECT and PET are widely used for medical imaging. However, radio isotopes available for SPECT and PET are limited. Under these circumstances, it is expected the appearance of the new $$gamma$$ imaging detector which can measure more various kinds of $$gamma$$-ray sources in order to develop new biomarkers using new radio isotopes. We set out to contribute to medical imaging technology by developing Electron-Tracking Compton Camera (ETCC) which can measure the various radioactive medicine.

Oral presentation

Production of $$^{95m}$$Tc for Compton camera imaging

Hatsukawa, Yuichi; Tsukada, Kazuaki; Hashimoto, Kazuyuki; Sato, Tetsuya; Asai, Masato; Toyoshima, Atsushi; Nagai, Yasuki; Tanimori, Toru*; Sonoda, Shinya*; Kabuki, Shigeto*; et al.

no journal, , 

In recent years, the Compton camera which is originally developed for the astrophysical studies was applied for medical diagnostic usage. For the Compton camera imaging require technetium isotopes emitting higher energy $$gamma$$-rays. Two Tc isotopes, $$^{95m}$$Tc (T$$_{1/2}$$ = 60 d; E$$gamma$$ = 204, 582 and 835 keV) and $$^{96}$$Tc(T$$_{1/2}$$ = 4.28 d, E$$gamma$$ = 778 and 812 keV) are candidates for Compton camera imaging. Compton camera imaging can realize high position resolution without collimator. Because of no collimator using, the Compton camera makes higher $$gamma$$-ray detection efficiency. Compared with SPECT with $$^{99m}$$Tc, the Compton camera imaging technique can be expected that radiation exposure deduce to 1/5-1/10. In this study, technetium-95m was produced by the $$^{95}$$Mo(p,n)$$^{95m}$$Tc reaction.

Oral presentation

Imaging test of the 3-D gamma-ray distribution in KUR reactor room using Electron-Tracking Compton Camera (ETCC)

Sonoda, Shinya*; Takada, Atsushi*; Tanimori, Toru*; Tsuda, Masaya*; Tahara, Keisuke*; Kobayashi, Koichiro*; Tanigaki, Minoru*; Taniguchi, Akihiro*; Nagai, Haruyasu; Nakayama, Hiromasa; et al.

no journal, , 

We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays. Here, we present the results of the gamma-imaging-spectroscopy with ETCC tested at the research reactor at the Institute for Integrated Radiation and Nuclear Science, Kyoto University.

Oral presentation

Detailed inspection of samples taken from un-irradiated fuel assembly at 1F4, 1; Outline of inspected samples and inspection methods

Motooka, Takafumi; Endo, Shinya; Sonoda, Takashi; Oki, Keiichi; Uehara, Hiroyuki; Obata, Hiroki; Tsukada, Takashi

no journal, , 

no abstracts in English

Oral presentation

Application of Electron Tracking Compton Camera (ETCC) in medical imaging

Sonoda, Shinya*; Nabetani, Akira*; Kimura, Hiroyuki*; Kabuki, Shigeto*; Takada, Atsushi*; Kubo, Hidetoshi*; Komura, Shotaro*; Sawano, Tatsuya*; Tanimori, Toru*; Matsuoka, Yoshihiro*; et al.

no journal, , 

We present the performance results using this new ETCC such as the imaging test using F-18 in point-like and rod-like phantoms with varying the intense of radiation. In addition, the measurementof Tc-95m which is produced by Japan Atomic Energy Agency was performed. Tc-95m emitsthe $$gamma$$-rays with the energy, 204, 583, and 835 keV, and then an image with multi-energies is examined. The position resolution achieves less than about 8 degrees from 10 degrees at 511 keV by this improvement. Further improvement of the angular resolution (position resolution) will be presented until 2015 spring. Also, we are developing the next ETCC by increasing the thickness of the scintillator from 1 rad. to 2 rad. and the gas pressure from 1 atm to 3 atm which improvethe detection efficiency by a factor of $$>$$ 5 at 511 keV. By these improvements, the imaging time of mouse is expected to be reduced from several hours with to $$<$$20 minutes for lots of kinds of RIs with the energy band from 0.1-2 MeV.

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