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Journal Articles

Effects of low- and high-LET radiation on the salt chemotaxis learning in ${it Caenorhabditis elegans}$

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Shimozawa, Yoko; Fukamoto, Kana*; Yokota, Yuichiro; Sora, Sakura*; Kakizaki, Takehiko*; Wada, Seiichi*; Funayama, Tomoo; et al.

Biological Sciences in Space, 26, p.21 - 25, 2012/10

High linear energy transfer (LET) radiation is important cosmic rays that has neurobiological effects: it is known to induce conditioned taste aversion, and suppress neurogenesis that may underlie cognitive impairment. However, the impact of high-LET radiation on other learning effects remains largely unknown. Here, we focus on kinetics of the radiation response for the salt chemotaxis learning (SCL) behavior in the nameatode, ${it Caenorhabditis elegans}$, because the SCL during the learning conditioning was modulated after low-LET $$gamma$$-irradiation. Firstly, the SCL ability was examined following high-LET irradiation ($$^{12}$$C, 18.3 MeV/u, LET = 113 keV/$$mu$$m), revealing its dose-dependent decrease after high- and low-LET exposure. Next, we demonstrate that the SCL at the early phase of the learning conditioning is greatly affected by high- and low-LET irradiation, and interestingly, the magnitude of these effects by high-LET radiation was smaller than that by low-LET one. Moreover, the analysis of ${it gpc-1}$ mutant showed that the G-protein $$gamma$$ subunit, GPC-1 is responsible for such early phase response. This study is the first to provide the evidence for the kinetics of changes in SCL after high-LET irradiation of C. ${it elegans}$.

Journal Articles

Behavioral resistance of ${it Caenorhabditis elegans}$ against high-LET radiation exposure

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Shimozawa, Yoko; Fukamoto, Kana*; Yokota, Yuichiro; Sora, Sakura*; Kakizaki, Takehiko*; Wada, Seiichi*; Funayama, Tomoo; et al.

Biological Sciences in Space, 26, p.7 - 11, 2012/07

Here, we investigated the resistance to high-LET radiation exposure for two behaviors of the nematode, ${it Caenorhabditis elegans}$, which is known as a model organism for the nervous system. Tested behaviors were locomotion and chemotaxis to NaCl. In addition, egg hatchability was examined as an indicator of high-LET radiation sensitivity. Relative biological effectiveness (RBE) of high-LET radiation ($$^{12}$$C, 18.3 MeV/u, LET = 113 keV/$$mu$$m) relative to low-LET radiation for hatchability was 4.5, whereas RBEs for locomotion and chemotaxis were 1.4 and 1.1, respectively. This study shows that the behavioral system for locomotion and chemotaxis of ${it C. elegans}$ is highly resistant to high-LET radiation exposure.

Journal Articles

Distinct response of irradiated normal human fibroblasts and their bystander cells to heavy-ion radiation in confluent cultures

Hamada, Nobuyuki*; Iwakawa, Mayumi*; Imadome, Kaori*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Ni, M.*; Imai, Takashi*; Kobayashi, Yasuhiko

Journal of Radiation Research, 50(Suppl.A), P. A118, 2009/05

Journal Articles

Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura; Yokota, Yuichiro; Nakano, Takashi*; Kobayashi, Yasuhiko

Radiotherapy and Oncology, 89(2), p.231 - 236, 2008/11

 Times Cited Count:22 Percentile:59.19(Oncology)

Journal Articles

The Small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation

Hamada, Nobuyuki*; Kataoka, Keiko*; Sora, Sakura*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Nakano, Takashi*; Kobayashi, Yasuhiko

Radiotherapy and Oncology, 89(2), p.227 - 230, 2008/11

 Times Cited Count:8 Percentile:31.07(Oncology)

Journal Articles

A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of $$gamma$$-rays and energetic heavy ions

Hamada, Nobuyuki*; Ni, M.*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Uchu Seibutsu Kagaku, 22(2), p.41 - 45, 2008/10

Journal Articles

Heavy-ion microbeam irradiation induces bystander killing of human cells

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Ni, M.*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Uchu Seibutsu Kagaku, 22(2), p.46 - 53, 2008/10

Journal Articles

Exposure of normal human fibroblasts to heavy-ion radiation promotes their morphological differentiation

Sora, Sakura*; Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Yokota, Yuichiro; Nakano, Takashi*; Kobayashi, Yasuhiko

Uchu Seibutsu Kagaku, 22(2), p.54 - 58, 2008/10

Journal Articles

The Survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Cancer Letters, 268(1), p.76 - 81, 2008/09

 Times Cited Count:10 Percentile:25.1(Oncology)

Oral presentation

Genomic instability induced in the descendants of normal human fibroblasts surviving heavy-ion irradiation

Hamada, Nobuyuki*; Hara, Takamitsu*; Sakashita, Tetsuya; Funayama, Tomoo; Sora, Sakura; Kobayashi, Yasuhiko

no journal, , 

Oral presentation

Heavy-ion irradiation overcomes the radioresistance of tumor cells overexpressing Bcl-2

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.

no journal, , 

no abstracts in English

Oral presentation

Exposure of normal human diploid fibroblasts to heavy ions accelerate differentiation in their progeny

Sora, Sakura; Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Heavy ion-induced differentiation of normal human fibroblasts

Sora, Sakura; Hamada, Nobuyuki*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Bystander effect studies using heavy-ion microbeam at JAEA-Takasaki

Kobayashi, Yasuhiko; Funayama, Tomoo; Sakashita, Tetsuya; Furusawa, Yoshiya*; Shao, C.*; Hamada, Nobuyuki*; Wada, Seiichi*; Yokota, Yuichiro; Kakizaki, Takehiko*; Fukamoto, Kana; et al.

no journal, , 

Oral presentation

Effects of $$gamma$$-ray irradiation on the basal slowing response in ${it Caenorhabditis elegans}$

Suzuki, Michiyo; Sakashita, Tetsuya; Funayama, Tomoo; Fukamoto, Kana; Hamada, Nobuyuki*; Yokota, Yuichiro; Kataoka, Keiko*; Sora, Sakura; Tsuji, Toshio*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Overcoming the radioresistance of Bcl-2 overexpressing tumor cells with heavy-ion irradiation

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.

no journal, , 

no abstracts in English

Oral presentation

Heavy ion-induced differentiation of normal human fibroblasts

Sora, Sakura; Hamada, Nobuyuki*; Funayama, Tomoo; Sakashita, Tetsuya; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Heavy ion-induced differentiation of normal human fibroblasts

Sora, Sakura; Hamada, Nobuyuki*; Kataoka, Keiko*; Kobayashi, Yasuhiko; Sakashita, Tetsuya; Funayama, Tomoo

no journal, , 

no abstracts in English

Oral presentation

HA14-1, an inhibitor of Bcl-2, may sensitize tumor cells to heavy ions

Kataoka, Keiko*; Hamada, Nobuyuki*; Sora, Sakura; Kobayashi, Yasuhiko; Sakashita, Tetsuya; Funayama, Tomoo

no journal, , 

no abstracts in English

Oral presentation

Overcoming the radioresistance of Bcl-2 overexpressing tumor cells with heavy-ion irradiation

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Omura, Motoko*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

30 (Records 1-20 displayed on this page)