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大場 洋次郎; 篠原 武尚; 佐藤 博隆*; 小野寺 陽平*; 廣井 孝介; Su, Y.; 杉山 正明*
Journal of the Physical Society of Japan, 87(9), p.094004_1 - 094004_5, 2018/09
被引用回数：1 パーセンタイル：11.98(Physics, Multidisciplinary)中性子小角散乱(SANS)は、ナノ構造の解析に有効な実験手法である。近年、中性子透過率に含まれるSANSの寄与を定量的に解析できる手法が開発され、中性子透過率スペクトルからSANSと同じくナノ構造情報が得られるようになった。これをパルス中性子透過イメージング実験に応用すれば、試料内のナノ構造の分布について高効率な2次元マッピングが可能になる。これを実現するためには、散乱中性子の検出器への入射を防ぐ必要がある。そこで本研究では、試料と検出器の間にソーラーコリメータを設置して散乱中性子を吸収、除去する方法を検討した。粒径の異なるシリカ微粒子を測定した結果、粒径によるSANSの違いを反映した中性子透過率スペクトルの違いを観測することに成功した。
大場 洋次郎*; 諸岡 聡; 佐藤 博隆*; 佐藤 信浩*; 井上 倫太郎*; 杉山 正明*
波紋, 26(4), p.170 - 173, 2016/11
Based on the time-of-light (TOF) technique, new generation pulsed neutron sources enable novel neutron scattering experiments. Using small-angle neutron scattering (SANS) at the pulsed neutron sources, simultaneous measurements of SANS and Bragg edge transmission can be performed. From the SANS profiles, the precipitates and inclusions in metals and alloys are characterized, while the Bragg edge transmission spectra give crystallographic information about the matrix. This is a powerful tool for quantitative characterization of the microstructures in the metals and alloys. The neutron transmission experiments have potential for further development. Magnetic Bragg edge transmission analysis will be useful for magnetic materials. These new neutron scattering techniques enhance the usability and flexibility of neutron scattering experiments.
柳衛 宏宣*; 熊田 博明*; 中村 剛実; 東 秀史*; 生嶋 一朗*; 森下 保幸*; 篠原 厚子*; 藤原 光輝*; 鈴木 実*; 櫻井 良憲*; et al.
Proceedings of 14th International Congress on Neutron Capture Therapy (ICNCT-14) (CD-ROM), p.157 - 160, 2010/10
In the treatment of hepatocellular carcinoma (HCC), only 30 % patients can be operated due to complication of liver cirrhosis or multiple intrahepatic tumours. Tumour cell destruction in BNCT is necessary to accumulate a sufficient quantity of 
B atoms in tumour cells. In this study, we prepared BSH entrapped WOW emulsion by double emulsifying technique using iodized poppy-seed oil (IPSO), BSH and surfactant, for selective intra-arterial infusion to HCC, and performed the neutron dosimetry using CT scan imaging of HCC patient. The B concentrations in VX-2 tumour obtained by delivery with WOW emulsion was superior to those by conventional IPSO mix emulsion. In case of HCC, we performed the feasibility estimation of 3D construction of tumor according to the CT imaging of a patient with epithermal neutron mode at JRR-4. Normal liver biologically weighted dose is restricted to 4.9 Gy-Eq; the max., min. and mean tumour weighted dose are 43.1, 7.3, and 21.8 Gy-Eq, respectively, in 40 minutes irradiation. In this study, we show that B entrapped WOW emulsion could be applied to novel intra-arterial boron delivery carrier for BNCT.
