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dynamics in the H conductors LaH
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Tamatsukuri, Hiromu; Fukui, Keiga*; Iimura, Soshi*; Honda, Takashi*; Tada, Tomofumi*; Murakami, Yoichi*; Yamaura, Junichi*; Kuramoto, Yoshio*; Sagayama, Hajime*; Yamada, Takeshi*; et al.
Physical Review B, 107(18), p.184114_1 - 184114_8, 2023/05
Times Cited Count：0 Percentile：0(Materials Science, Multidisciplinary)Tada, Hiroyuki*; Kumasaka, Hiroo*; Saito, Akira*; Nakaya, Atsushi*; Ishii, Takashi*; Fujita, Tomoo; Sugita, Yutaka; Nakama, Shigeo; Sanada, Masanori*
Doboku Gakkai Rombunshu, F2 (Chika Kukan Kenkyu) (Internet), 73(1), p.11 - 28, 2017/03
This study examined the mechanical characteristics of rock segments and backfill materials and analyzed the stability of the drift that is supported by the rock segments and gravel backfill. The results confirmed the technical aspects of the formation of the rock segments and the effectiveness of the planned efforts to further reduce the amount of cement used.
Sanada, Hiroyuki; Sato, Toshinori; Tanno, Takeo*; Hikima, Ryoichi*; Tada, Hiroyuki*; Kumasaka, Hiroo*; Ishii, Takashi*; Sakurai, Hideyuki*
JAEA-Research 2014-006, 124 Pages, 2014/06
JAEA-Research-2014-006.pdf:11.26MB
Japan Atomic Energy Agency has been implementing the Mizunami Underground Research Laboratory (MIU) Project in order to develop the comprehensive investigation techniques for the geological environment and the engineering techniques to construct a deep underground laboratory in crystalline rock. In the rock mechanical study in the MIU Project, the development of the evaluation method for the excavation damaged zone due to excavation of shafts and research galleries is one of the important issues. In this report, crack tensor was calculated using the tunnel wall mapping and rock mechanical test results in the shaft and research galleries in the MIU. Two dimension excavation analysis was conducted at the Ventilation Shaft and GL -500 m Sub Stage using the calculated crack tensor at GL -500 m. Based on calculated crack tensor at GL 500 m, validation of the crack tensor at GL -500 m estimated during Phase I was verified. Relative error of crack tensor was calculated in order to examine variation of relative error to the scale of observation areas.
Tada, Hiroyuki*; Kumasaka, Hiroo*; Saito, Akira*; Nakaya, Atsushi*; Ishii, Takashi*; Sanada, Masanori; Noguchi, Akira*; Kishi, Hirokazu*; Nakama, Shigeo; Fujita, Tomoo
Dai-13-Kai Iwa No Rikigaku Kokunai Shimpojiumu Koen Rombunshu (CD-ROM), p.133 - 138, 2013/01
The authors have been developing methods for constructing tunnels using the minimum quantities of cement-type support materials in high-level radioactive waste disposal facilities and advancing research and development about the technical formation of rock segment using low alkaline mortar. In this study, the mechanical characteristic values concerning the rock segment and backfill materials were examined. The stability analysis of tunnel supported by the rock segment and backfilling with gravel were performed. Technical formation and effectiveness of the alternative supports planned for further reduction in cement influence was confirmed from a study result above-mentioned.
Tanno, Takeo; Sato, Toshinori; Sanada, Hiroyuki; Hikima, Ryoichi; Matsui, Hiroya; Tada, Hiroyuki*; Goke, Mitsuo*; Kumasaka, Hiroo*; Ishii, Takashi*
JAEA-Research 2012-002, 86 Pages, 2012/03
JAEA-Research-2012-002.pdf:8.48MB
The Crack tensor model which is a kind of equivalent continuum model has been studied in rock mechanical investigation in the MIU. The fractured rock mass is modeled as the elastic continuum model with the crack tensor. In this study, crack tensor based on the geological observation in the MIU project was calculated, and REV (Representative Elementary Volume) in the shafts and research galleries was studied based on the relative error of the crack tensor. The correlation between the crack density, the trace length of crack and the trace of crack tensor and the rock mass classification was also studied.
Hayashi, Katsuhiko; Noguchi, Akira; Kishi, Hirokazu; Kabayashi, Yasushi*; Nakama, Shigeo; Fujita, Tomoo; Naito, Morimasa; Tada, Hiroyuki*; Kumasaka, Hiroo*; Goke, Mitsuo*; et al.
JAEA-Research 2010-057, 101 Pages, 2011/03
JAEA-Research-2010-057.pdf:7.47MB
Cement-type materials that are used for supports or grouting at high-level radioactive waste disposal facilities leach into the groundwater and create a highly alkaline environment. Of concern in highly alkaline environments are the alteration of bentonite used as buffers or backfill materials, and of surrounding rock mass, and the increased uncertainty regarding the provision of performance of the disposal system over a long period of time. In this study, to reduce the quantity of cement-type materials that cause highly alkaline environments, technical feasibility of the support structure including the materials which considered the long-term performance of the HLW disposal system are discussed by using knowledge and technology accumulated in JAEA and Shimizu Construction. Moreover, based on the results, the problems remained in the application to the future HLW disposal institution are summarized.
Konishi, Tomoya*; Nishiwaki, Nagatoshi*; Tojo, Takashi*; Ishikawa, Takuma*; Teraoka, Teruki*; Ueta, Yukiko*; Kihara, Yoshifumi*; Moritoki, Hideji*; Tono, Tatsuo*; Musashi, Mio*; et al.
Physica Status Solidi (C), 8(2), p.405 - 407, 2011/02
Times Cited Count：3 Percentile：74.8(Engineering, Electrical & Electronic)Matsui, Hiroya; Tanno, Takeo; Hirano, Toru*; Goke, Mitsuo*; Kumasaka, Hiroo*; Tada, Hiroyuki*; Ishii, Takashi*
JAEA-Research 2010-043, 87 Pages, 2010/12
JAEA-Research-2010-043.pdf:3.99MB
The results are as follows (1) For the ventilation shaft at GL-350m, the crack tensor deformation analysis based on FY2004 work's results showed the calculated displacement was smaller than the measured displacement. A geometrical parameters of fractures in FY2004 work's result was different from one based on geological observation in the shaft. Therefore, the crack tensor of FY2004 work's results seems to be underestimated. (2) Large discontinuities with NE strike and high dipping observed in a shaft were major reason for the difference of crack tensors determined by borehole investigation from surface and geological observations in a shaft. Therefore, the crack tensor for pilot borehole investigation in a shaft was calculated as well and compared with each results. It was found that the fabric tensor is similar with it of geological observation and the vale was medium. (3) The crack tensor around GL-500m was estimated by relation of statistical quantities for fractures between GL-300m and GL-500m. Consequently, the deformation analysis based on the estimated crack tensor showed an increase in convergence and stress in the support system compared to FY2004 work's results.
Tamada, Taro; Kinoshita, Takayoshi*; Kurihara, Kazuo; Adachi, Motoyasu; Ohara, Takashi; Imai, Keisuke*; Kuroki, Ryota; Tada, Toshiji*
Journal of the American Chemical Society, 131(31), p.11033 - 11040, 2009/07
Times Cited Count：58 Percentile：79.01(Chemistry, Multidisciplinary)To help resolve long-standing questions regarding the catalytic activity of the serine proteases the structure of porcine pancreatic elastase has been analyzed by high-resolution neutron and X-ray crystallography. In order to mimic the tetrahedral transition intermediate a peptidic inhibitor was used. A single large crystal was used to collect room-temperature neutron data to 1.65 
resolution and X-ray data to 1.20 resolution. Another crystal provided a low-temperature X-ray data set to 0.94 resolution. The neutron data are to higher resolution than previously reported for a serine protease and the X-ray data are comparable with other studies. The neutron and X-ray data show that the hydrogen bond between His57 and Asp102 (chymotrypsin numbering) is 2.60 in length and that the hydrogen-bonding hydrogen is 0.80-0.96 from the histidine nitrogen. This is not consistent with a low-barrier hydrogen which is predicted to have the hydrogen midway between the donor and acceptor atom. The observed interaction between His57 and Asp102 is essentially a short but conventional hydrogen bond, sometimes described as a short ionic hydrogen bond. The neutron analysis also shows that the oxygen of the oxopropyl group of the inhibitor is present as an oxygen anion rather than a hydroxyl group, supporting the role of the "oxyanion hole" in stabilizing the tetrahedral intermediate in catalysis.
Yamasaki, Chisato*; Murakami, Katsuhiko*; Fujii, Yasuyuki*; Sato, Yoshiharu*; Harada, Erimi*; Takeda, Junichi*; Taniya, Takayuki*; Sakate, Ryuichi*; Kikugawa, Shingo*; Shimada, Makoto*; et al.
Nucleic Acids Research, 36(Database), p.D793 - D799, 2008/01
Times Cited Count：51 Percentile：71.25(Biochemistry & Molecular Biology)Here we report the new features and improvements in our latest release of the H-Invitational Database, a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of fulllength cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 protein-coding and 642 non-protein-coding loci; 858 transcribed loci overlapped with predicted pseudogenes.
Yamada, Hidenori*; Tamada, Taro; Kosaka, Megumi*; Miyata, Kohei*; Fujiki, Shinya*; Tano, Masaru*; Moriya, Masayuki*; Yamanishi, Mamoru*; Honjo, Eijiro; Tada, Horiko*; et al.
Protein Science, 16(7), p.1389 - 1397, 2007/07
Times Cited Count：39 Percentile：59.61(Biochemistry & Molecular Biology)In an attempt to control protein incorporation in a crystal lattice, a leucine zipper-like hydrophobic interface (comprising four leucine residues) was introduced into a helical region (helix 2) of the human pancreatic ribonuclease 1 (RNase 1) that was predicted to form a suitable crystallization interface. Although crystallization of wild type RNase 1 has not yet been reported, the RNase 1 mutant having four leucines (4L-RNase 1) was successfully crystallized under several different conditions. The crystal structures were subsequently determined by X-ray crystallography by molecular replacement using the structure of bovine RNase A. The overall structure of 4L-RNase 1 is quite similar to that of the bovine RNase A, and the introduced leucine residues formed the designed crystal interface. To further characterize the role of the introduced leucine residues in crystallization of RNase 1, the number of leucines was reduced to three or two (3L- and 2L-RNase 1, respectively). Both mutants crystallized and a similar hydrophobic interface as in 4L-RNase 1 was observed. A related approach to engineer crystal contacts at helix 3 of RNase 1 (N4L-RNase 1) was also evaluated. N4L-RNase 1 also successfully crystallized, and formed the expected hydrophobic packing interface. These results suggest that appropriate introduction of a leucine zipper-like hydrophobic interface can promote intra molecular symmetry for more efficient protein crystallization in crystal lattice engineering efforts.
Amano, Hikaru; Kabuto, Shoji; Kinoshita, Naoki; Suzuki, Takashi; Tanaka, Takayuki; Otosaka, Shigeyoshi; Kuwabara, Jun; Kitada, Yoshinobu*; Watanabe, Yukiya*; Kitamura, Toshikatsu
Dai-19-Kai Tandemu Kasokuki Oyobi Sono Shuhen Gijutsu No Kenkyukai Hokokushu, p.1 - 4, 2007/01
no abstracts in English
Kitamura, Toshikatsu; Kabuto, Shoji*; Suzuki, Takashi; Amano, Hikaru; Kitada, Yoshinobu*; Watanabe, Yukiya*
Dai-17-Kai Tandemu Kasokuki Oyobi Sono Shuhen Gijutsu No Kenkyukai Hokokushu, p.52 - 55, 2004/12
no abstracts in English
Kitamura, Toshikatsu; Kabuto, Shoji*; Suzuki, Takashi; Togawa, Orihiko; Kitada, Yoshinobu*; Watanabe, Yukiya*
Dai-16-Kai Tandemu Kasokuki Oyobi Sono Shuhen Gijutsu No Kenkyukai Hokokushu, p.27 - 31, 2004/02
no abstracts in English
Seki, Masahiro; Hishinuma, Akimichi; Kurihara, Kenichi; Akiba, Masato; Abe, Tetsuya; Ishitsuka, Etsuo; Imai, Tsuyoshi; Enoeda, Mikio; Ohira, Shigeru; Okumura, Yoshikazu; et al.
Kaku Yugoro Kogaku Gairon; Mirai Enerugi Eno Chosen, 246 Pages, 2001/09
no abstracts in English
Yoshimi, Takashi*; Kakudate, Satoshi; Tada, Eisuke; Tsuji, Koichi*; Miyagawa, Shinichi*; Kubo, Tomomi*
Nihon Robotto Gakkai-Shi, 19(6), p.766 - 774, 2001/09
no abstracts in English
Kakudate, Satoshi; Oka, Kiyoshi; Yoshimi, Takashi*; Taguchi, Ko*; Nakahira, Masataka; Takeda, Nobukazu; Shibanuma, Kiyoshi; Obara, Kenjiro; Tada, Eisuke; Matsumoto, Yasuhiro*; et al.
Fusion Engineering and Design, 51-52(1-4), p.993 - 999, 2000/11
Times Cited Count：9 Percentile：54.14(Nuclear Science & Technology)no abstracts in English
*; Nakahira, Masataka; Hamada, Kazuya; Takahashi, Hiroyuki*; Tada, Eisuke; Kato, Takashi; *
JAERI-Tech 99-027, 113 Pages, 1999/03
no abstracts in English
Shimizu, Katsusuke*; *; Koizumi, Koichi; *; Nishio, Satoshi; Sasaki, Takashi*; Tada, Eisuke
JAERI-M 92-135, 139 Pages, 1992/09
no abstracts in English
*; Nishio, Satoshi; *; Koizumi, Koichi; Shimizu, Katsusuke*; Sasaki, Takashi*; Tada, Eisuke
JAERI-M 92-108, 62 Pages, 1992/07
no abstracts in English
