Production rates of long-lived radionuclides Be and Al under direct muon-induced spallation in granite quartz and its implications for past high-energy cosmic ray fluxes

Sakurai, Hirohisa*; Kurebayashi, Yutaka*; Suzuki, Soichiro*; Horiuchi, Kazuho*; Takahashi, Yui*; Doshita, Norihiro*; Kikuchi, Satoshi*; Tokanai, Fuyuki*; Iwata, Naoyoshi*; Tajima, Yasushi*; et al.

Physical Review D, 109(10), p.102005_1 - 102005_18, 2024/05

https://doi.org/10.1103/PhysRevD.109.102005

Secular variations of galactic cosmic rays (GCRs) are inseparably associated with the galactic activities and should reflect the environments of the local galactic magnetic field, interstellar clouds, and nearby supernova remnants. The high-energy muons produced in the atmosphere by high-energy GCRs can penetrate deep underground and generate radioisotopes in the rock. As long lived radionuclides such as Be and Al have been accumulating in these rocks, concentrations of Be and Al can be used to estimate the long-term variations in high-energy muon yields, corresponding to those in the high-energy GCRs over a few million years. This study measured the production cross sections for muon induced Be and Al by irradiating positive muons with the momentum of 160 GeV/c on the synthetic silica plates and the granite core at the COMPASS experiment line in CERN SPS. In addition, it the contributions of the direct muon spallation reaction and the nuclear reactions by muon-induced particles on the production of long lived radionuclides in the rocks were clarified.

Spin dependence in the -wave resonance of +

Okudaira, Takuya*; Nakabe, Rintaro*; Auton, C. J.*; Endo, Shunsuke; Fujioka, Hiroyuki*; Gudkov, V.*; Ide, Ikuo*; Ino, Takashi*; Ishikado, Motoyuki*; Kambara, Wataru*; et al.

Physical Review C, 109(4), p.044606_1 - 044606_9, 2024/04

https://doi.org/10.1103/PhysRevC.109.044606

Neutron/-ray discrimination based on the property and thickness controls of scintillators using Li glass and LiCAF(Ce) in a -ray field

Kaburagi, Masaaki; Shimazoe, Kenji*; Terasaka, Yuta; Tomita, Hideki*; Yoshihashi, Sachiko*; Yamazaki, Atsushi*; Uritani, Akira*; Takahashi, Hiroyuki*

Nuclear Instruments and Methods in Physics Research A, 1046, p.167636_1 - 167636_8, 2023/01

https://doi.org/10.1016/j.nima.2022.167636

We focus on the thickness and property controls of inorganic scintillators used for thermal neutron detection in intense -ray fields without considering pulse shape discrimination techniques. GS20 (a lithium glass) and LiCaAlF:Ce(LiCAF:Ce) cintillators with thicknesses of 0.5 and 1.0 mm, respectively, have been employed. Pulse signals generated by photomultiplier tubes, to which the scintillators were coupled, were inserted into a digital pulse processing unit with 1 Gsps, and the areas of waveforms were integrated for 360 ns. In a Co -ray field, the neutron detection for GS20 with a 0.5-mm thickness was possible at dose rates of up to 0.919 Gy/h; however, for LiCAF:Ce, neutron detection was possible at 0.473 Gy/h, and it failed at 0.709 Gy/h. Threfore, in a Co -ray field, the neutron/-ray discrimination of GS20 was better than that of LiCAF:Ce due to its better energy resolution and higher detection efficiency.

Interfacial distribution of Nafion ionomer thin films on nitrogen-modified carbon surfaces

Yoshimune, Wataru*; Kikkawa, Nobuaki*; Yoneyama, Hiroaki*; Takahashi, Naoko*; Minami, Saori*; Akimoto, Yusuke*; Mitsuoka, Takuya*; Kawaura, Hiroyuki*; Harada, Masashi*; Yamada, Norifumi*; et al.

ACS Applied Materials & Interfaces, 14(48), p.53744 - 53754, 2022/11

https://doi.org/10.1021/acsami.2c14574

Identification and quantification of a Co radiation source under an intense Cs radiation field using an application-specific CeBr spectrometer suited for use in intense radiation fields

Kaburagi, Masaaki; Shimazoe, Kenji*; Kato, Masahiro*; Kurosawa, Tadahiro*; Takahashi, Hiroyuki*

Journal of Nuclear Science and Technology, 59(8), p.983 - 992, 2022/08

https://doi.org/10.1080/00223131.2022.2026833

4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication

Saga, Ryo*; Matsuya, Yusuke; Takahashi, Rei*; Hasegawa, Kazuki*; Date, Hiroyuki*; Hosokawa, Yoichiro*

Scientific Reports (Internet), 11(1), p.8258_1 - 8258_10, 2021/04

https://doi.org/10.1038/s41598-021-87850-3

Hyaluronan synthesis inhibitor 4-methylumbelliferone (4-MU) is a candidate of radiosensitizers in X-ray therapy. The curative effects under such 4-MU administration have been investigated in vitro; however, the radiosensitizing mechanisms remain unclear. Here, we investigated the radiosensitizing effects under 4-MU treatment from cell experiments and model estimations. We generated experimental surviving fractions of human fibrosarcoma cells (HT1080) after 4-MU treatment combined with X-ray irradiation. Meanwhilst, we also modelled the pharmacological effects of 4-MU treatment and theoretically analyzed the synergetic effects between 4-MU treatment and X-ray irradiation. The results show that the enhancement of cell killing by 4-MU treatment is the greatest in the intermediate dose range of around 4 Gy, which indicates the involvement of intercellular communication. In addition, the oxidative stress level, which leads to DNA damage induction, significantly increased under 4-MU treatment, and the radiosensitization by 4-MU can be suppressed by the inhibitors for intercellular communication. These findings suggest that the synergetic effects between 4-MU treatment and irradiation are predominantly attributed to intercellular communication and provide more efficient tumour control than conventional X-ray therapy.

Gamma-ray spectroscopy with a CeBr scintillator under intense -ray fields for nuclear decommissioning

Kaburagi, Masaaki; Shimazoe, Kenji*; Kato, Masahiro*; Kurosawa, Tadahiro*; Kamada, Kei*; Kim, K. J.*; Yoshino, Masao*; Shoji, Yasuhiro*; Yoshikawa, Akira*; Takahashi, Hiroyuki*; et al.

Nuclear Instruments and Methods in Physics Research A, 988, p.164900_1 - 164900_8, 2021/02

https://doi.org/10.1016/j.nima.2020.164900

An increasing number of nuclear facilities have been decommissioned worldwide following the 2011 accident of the TEPCO' Fukushima Daiichi Nuclear Power Station. During the decommissioning, radioactive materials have to be retrieved under proper management. In this study, a small cubic CeBr spectrometer with dimensions of 5 mm 5 mm 5 mm was manufactured to perform -ray spectroscopy under intense -ray fields. Furthermore, thanks to a fast digital process unit and a customized photomultiplier, the device could perform -ray spectroscopy at dose rates of over 1 Sv/h. The energy resolution (FWHM) at 662 keV ranged from 4.4% at 22 mSv/h to 5.2% at 1407 mSv/h for a Cs radiation field. Correspondingly, at 1333 keV, it ranged from 3.1% at 26 mSv/h to 4.2% at 2221 mSv/h for a Co radiation field, which suggested to realize -ray assessment of Cs, Cs, Co, and Eu at dose rates of over 1 Sv/h.

A Cubic CeBr gamma-ray spectrometer suitable for the decommissioning of the Fukushima Daiichi Nuclear Power Station

Kaburagi, Masaaki; Shimazoe, Kenji*; Otaka, Yutaka*; Uenomachi, Mizuki*; Kamada, Kei*; Kim, K. J.*; Yoshino, Masao*; Shoji, Yasuhiro*; Yoshikawa, Akira*; Takahashi, Hiroyuki*; et al.

Nuclear Instruments and Methods in Physics Research A, 971, p.164118_1 - 164118_8, 2020/08

https://doi.org/10.1016/j.nima.2020.164118

scattering length from photoproduction on the proton near the reaction threshold

Ishikawa, Takatsugu*; Fujimura, Hisako*; Fukasawa, Hiroshi*; Hashimoto, Ryo*; He, Q.*; Honda, Yuki*; Hosaka, Atsushi; Iwata, Takahiro*; Kaida, Shun*; Kasagi, Jirota*; et al.

Physical Review C, 101(5), p.052201_1 - 052201_6, 2020/05

https://doi.org/10.1103/PhysRevC.101.052201

Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model

Saga, Ryo*; Matsuya, Yusuke; Takahashi, Rei*; Hasegawa, Kazuki*; Date, Hiroyuki*; Hosokawa, Yoichiro*

Journal of Radiation Research, 60(3), p.298 - 307, 2019/05

https://doi.org/10.1093/jrr/rrz011

In radiotherapy, it is recognized that cancer stem cells (CSCs) in tumor tissue shows radio-resistance. However, the relationship between content percentage of the CSCs and dose-response curve on cell survival remain unclear. In this study, we developed a stochastic model considering progeny cells and stem cells, and investigated the impact of stem cells on radio-sensitivity. From the flow-cytometric analysis (cell experiments), the content percentage of stem cells was 3.2% or less which agreed well with the model estimation from the cell survival curve. Based on the verification, it is suggested that cell survival in high-dose range is largely affected by the CSCs. In addition, regarding the sub-population of stem cells, the present model well reproduces the dose response on lethal lesions to DNA comparing with the conventional LQ model. This outcome indicates that the stem cells must be considered for describing the dose-response curve in wide dose range.