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Sasada, Seiji*; Takahashi, Yoshihito*; Takeuchi, Keisuke*; Hiroi, Kosuke; Su, Y. H.; Shinohara, Takenao; Watanabe, Kenichi*; Uritani, Akira*
Japanese Journal of Applied Physics, 61(4), p.046004_1 - 046004_8, 2022/03
Times Cited Count:0 Percentile:0(Physics, Applied)Ishikawa, Takatsugu*; Fujimura, Hisako*; Fukasawa, Hiroshi*; Hashimoto, Ryo*; He, Q.*; Honda, Yuki*; Hosaka, Atsushi; Iwata, Takahiro*; Kaida, Shun*; Kasagi, Jirota*; et al.
Physical Review C, 101(5), p.052201_1 - 052201_6, 2020/05
Times Cited Count:4 Percentile:44.35(Physics, Nuclear)Tsuda, Shuichi; Sato, Tatsuhiko; Takahashi, Fumiaki; Satoh, Daiki; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
Journal of Radiation Research, 53(2), p.264 - 271, 2012/04
Times Cited Count:14 Percentile:55.64(Biology)Deposit energy distribution in microscopic site is basic information for understanding of biological effects of energetic heavy ion beams. To estimate RBE, lineal energy, , can be an appropriate physical index. In this work, a wall-less tissue equivalent proportional counter has been designed and used for the measurement of distributions, (), for 160 MeV H, 150 MeV/u He, 290 MeV/u C, 490 MeV/u Si and 500 MeV/u Ar. Data of () were also obtained in the wide range of LET. The dose-means of , , were compared with those calculated by the microdosimetric function of PHITS. It is found that the calculated () and agree fairly well with those measured. The values of are larger than those of LET less than 10 keV/m because of the discrete energy deposition by delta rays, while the relation is reversed above 10 keV/m. The results indicate that care should be taken in the difference between and LET when the values of RBE of energetic heavy ions are estimated.
Narumi, Kazumasa; Naramoto, Hiroshi*; Yamada, Keisuke; Saito, Yuichi; Chiba, Atsuya; Takahashi, Yasuyuki*; Maeda, Yoshihito
JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 155, 2012/01
no abstracts in English
Tsuda, Shuichi; Sato, Tatsuhiko; Takahashi, Fumiaki; Satoh, Daiki; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
KEK Proceedings 2011-8, p.100 - 108, 2011/12
Deposit energy distribution in microscopic site is basic information for understanding of biological effects of energetic heavy ion beams. To estimate RBE, lineal energy, y, can be an appropriate physical index. In this work, a wall-less tissue equivalent proportional counter has been designed and used for the measurement of y distributions, , for 160 MeV H, 150 MeV/u He and 490 MeV/u Si ion beams. Data of and the dose-means of , , were compared with those calculated by the microdosimetric function of PHITS. It is found that the calculated and agree fairly well with those measured, as well as the already reported result of 290 MeV/u carbon beam.
Tsuda, Shuichi; Sato, Tatsuhiko; Satoh, Daiki; Takahashi, Fumiaki; Sasaki, Shinichi*; Namito, Yoshihito*; Sanami, Toshiya*; Saito, Kiwamu*; Takada, Masashi*
HIMAC-136, p.219 - 220, 2011/11
Measurements of lineal energy distribution were employed using 160 MeV proton and 490 MeV/u Si. The calculated by PHITS and agree fairly well with those measured. The LET dependence of was obtained from 3 to 300 keV/um in this project.
Tsuda, Shuichi; Sato, Tatsuhiko; Takahashi, Fumiaki; Satoh, Daiki; Endo, Akira; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
Radiation Protection Dosimetry, 143(2-4), p.450 - 454, 2011/02
Times Cited Count:5 Percentile:38.51(Environmental Sciences)A wall-less tissue equivalent proportional counter, wall-less TEPC, has been designed and used for the measurement of the y distributions for energetic heavy ions in order to verify a biological dose calculation model incorporated in the PHITS code. It is found that the dose-mean value of y obtained by the wall-less TEPC is 50 - 60% of the LET of the argon ions in water, since the delta-rays with relatively low y can be measured.
Tsuda, Shuichi; Sato, Tatsuhiko; Takahashi, Fumiaki; Satoh, Daiki; Endo, Akira; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
Physics in Medicine & Biology, 55(17), p.5089 - 5101, 2010/09
Times Cited Count:24 Percentile:60.65(Engineering, Biomedical)The frequency distribution of the lineal energy of 290 MeV/u carbon beam was measured using a wall-less tissue equivalent proportional counter (wall-less TEPC) in a cylindrical volume with simulated diameter 0.72 m in verifying the accuracy of a dose calculation model. The measured lineal energy distribution as well as its dose-mean value agreed fairly well with the corresponding data from microdosimetric calculations using the PHITS code within the experimental uncertainty. It is found that a wall-less TEPC is needed to measure the precise energy deposition spectra of the delta rays produced secondarily by energetic heavy ion beams. The measured data also indicate that more than 11% of the energy escaped from the path of the trajectory of the carbon beam.
Tsuda, Shuichi; Sato, Tatsuhiko; Satoh, Daiki; Takahashi, Fumiaki; Endo, Akira; Sasaki, Shinichi*; Namito, Yoshihito*; Sanami, Toshiya*; Saito, Kiwamu*; Takada, Masashi*
HIMAC-134 (CD-ROM), p.227 - 228, 2010/06
no abstracts in English
Tsuda, Shuichi; Sato, Tatsuhiko; Takahashi, Fumiaki; Satoh, Daiki; Endo, Akira; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
KEK Proceedings 2009-12, p.36 - 44, 2010/01
Knowledge of energy deposition at micrometer dimensions along heavy ion tracks is essential to understand the biological effects of radiation. Wall-less tissue equivalent proportional counter (wall-less TEPC) was produced for the purpose of measurement of lineal energy distribution including secondary-produced high-energy electrons, delta-rays. The measurement using the wall-less TEPC was performed at Heavy Ion Medical Accelerator at NIRS, Japan. It is found that lineal energy distributions could be measured for primary carbon beam with energy of 400MeV per nucleon and delta-rays. Detail of the experiment, energy calibration and estimation of delta-rays production will be presented.
Takahashi, Yasuyuki; Narumi, Kazumasa; Chiba, Atsuya; Saito, Yuichi; Yamada, Keisuke; Ishikawa, Norito; Sugai, Hiroyuki; Maeda, Yoshihito
EPL; A Letters Journal Exploring the Frontiers of Physics, 88(6), p.63001_1 - 63001_6, 2009/12
Times Cited Count:7 Percentile:45.45(Physics, Multidisciplinary)C and C ions with 62.5-250 keV/u were incident on self-supporting amorphous carbon foils of 1.4-150 g/cm (70-7500 ). The secondary electrons emitted in the forward direction from a carbon foil were detected by a microchannel-plate detector placed at the exit side of the target. The vicinage effect on the secondary-electron yield was evaluated with the ratio of the secondary-electron yield R = /2, where and are the yields induced by the C and C ion with the same velocity, respectively. For the first time the disappearance of the vicinage effect on the secondary-electron yield from amorphous carbon foils bombarded with 62.5 keV/u C ions was observed for thick foils of 61-150 g/cm. The internuclear distance between the fragment ions at the exit of the target was evaluated by calculating trajectories of the fragment ions considering the Coulomb explosion. For a 62.5 keV/u C ion, we have determined the threshold internuclear distance where the vicinage effect disappears exits between 6 and 23 . It is expected that the vicinage effect on the energy loss (production process) in this velocity region disappears at the internuclear distance of a few . This result means that the transport or transmission process is important for the appearance of the vicinage effect. Moreover, the threshold internuclear distance depends on the velocity of the ion and increases as the velocity increases. The average charge of the ion increases with increase of the velocity of the ion. These mean that there is a possibility that a charge state plays an important role in the origin of the vicinage effect. In order to account for the experimental results, we discussed two models taking account of two kinds of potentials induced in response to the charge of the fragment ion in the transport process.
Tsuda, Shuichi; Sato, Tatsuhiko; Satoh, Daiki; Takahashi, Fumiaki; Endo, Akira; Sasaki, Shinichi*; Namito, Yoshihito*; Sanami, Toshiya*; Saito, Kiwamu*; Takada, Masashi*
NIRS-M-226, HIMAC-132, p.264 - 265, 2009/06
A wall-less tissue equivalent proportional counter was designed and applied to measuring deposit energy distribution of heavy ion beams, including the contribution of delta-rays produced along heavy ion tracks. Lineal energy distributions were obtained for 400 MeV/u carbon and 490 MeV/u silicon beams.
Yamasaki, Chisato*; Murakami, Katsuhiko*; Fujii, Yasuyuki*; Sato, Yoshiharu*; Harada, Erimi*; Takeda, Junichi*; Taniya, Takayuki*; Sakate, Ryuichi*; Kikugawa, Shingo*; Shimada, Makoto*; et al.
Nucleic Acids Research, 36(Database), p.D793 - D799, 2008/01
Times Cited Count:52 Percentile:71.15(Biochemistry & Molecular Biology)Here we report the new features and improvements in our latest release of the H-Invitational Database, a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of fulllength cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 protein-coding and 642 non-protein-coding loci; 858 transcribed loci overlapped with predicted pseudogenes.
Tsuda, Shuichi; Sato, Tatsuhiko; Endo, Akira; Satoh, Daiki; Takahashi, Fumiaki; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
no journal, ,
Energy deposition of secondary charged particles produced in tissue irradiated by heavy ion beams is important information in order to evaluate biological effects of cells. In this study a wall-less tissue equivalent proportional counter (wall-less TEPC) was designed and its performance tests have been carried out using checking sources such as a Cm-244 source. It is found that the wall-less TEPC can be used in measurements of energy deposition in tissue irradiated by heavy ion beams, based on measurements of gas gain in tissue equivalent gas and lineal energy distributions.
Narumi, Kazumasa; Naramoto, Hiroshi*; Takahashi, Yasuyuki; Yamada, Keisuke; Saito, Yuichi; Chiba, Atsuya; Adachi, Masahiro; Maeda, Yoshihito
no journal, ,
no abstracts in English
Tsuda, Shuichi; Sato, Tatsuhiko; Takahashi, Fumiaki; Satoh, Daiki; Endo, Akira; Sasaki, Shinichi*; Namito, Yoshihito*; Iwase, Hiroshi*; Ban, Shuichi*; Takada, Masashi*
no journal, ,
Knowledge of energy deposition at micrometer dimensions along heavy ion tracks is essential to understand the biological effects of radiation. Wall-less tissue equivalent proportional counter (TEPC) was produced for the purpose of measurement of lineal energy distribution of delta-rays. The measurement using the TEPC was performed at Heavy Ion Medical Accelerator at NIRS, Japan. It is found that lineal energy distributions could be measured for primary carbon beam with energy of 400MeV per nucleon and delta-rays. Detail of the experiment, energy calibration and estimation of delta-rays production will be presented.
Takahashi, Yasuyuki; Narumi, Kazumasa; Chiba, Atsuya; Saito, Yuichi; Yamada, Keisuke; Ishikawa, Norito; Sugai, Hiroyuki; Maeda, Yoshihito
no journal, ,
no abstracts in English
Takahashi, Yasuyuki; Narumi, Kazumasa; Chiba, Atsuya; Saito, Yuichi; Yamada, Keisuke; Ishikawa, Norito; Sugai, Hiroyuki; Maeda, Yoshihito
no journal, ,
no abstracts in English
Takahashi, Yasuyuki; Narumi, Kazumasa; Chiba, Atsuya; Saito, Yuichi; Yamada, Keisuke; Ishikawa, Norito; Sugai, Hiroyuki; Maeda, Yoshihito
no journal, ,
no abstracts in English
Naramoto, Hiroshi*; Takahashi, Yasuyuki; Yamada, Keisuke; Chiba, Atsuya; Adachi, Masahiro*; Saito, Yuichi; Maeda, Yoshihito; Narumi, Kazumasa
no journal, ,