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pellets for Mo-99 production, 2Nishikata, Kaori; Ishida, Takuya; Yonekawa, Minoru; Kato, Yoshiaki; Kurosawa, Makoto; Kimura, Akihiro; Matsui, Yoshinori; Tsuchiya, Kunihiko; Sano, Tadafumi*; Fujihara, Yasuyuki*; et al.
KURRI Progress Report 2014, P. 109, 2015/07
As one of effective applications of the Japan Materials Testing Reactor (JMTR), JAEA has a plan to produce 
Mo by (n,
) method ((n,)Mo production), a parent nuclide of 
Tc. In this study, preliminary irradiation test was carried out with the high-density molybdenum trioxide (MoO) pellets in the hydraulic conveyer (HYD) of the Kyoto University Research Reactor (KUR) and the Tc solution extracted from Mo was evaluated. After the irradiation test of the high-density MoO pellets in the KUR, Tc was extracted from the Mo solution and the recovery rate of Tc achieved the target values. The Tc solution also got the value that satisfied the standard value for Tc radiopharmaceutical products by the solvent extraction method.
Taguchi, Yasujiro*; Sakai, Hideaki*; Okuyama, Daisuke*; Ishiwata, Shintaro*; Fujioka, Jun*; Fukuda, Tatsuo; Hashizume, Daisuke*; Kagawa, Fumitaka*; Takahashi, Yoichiro*; Shimano, Ryo*; et al.
Physica B; Condensed Matter, 407(11), p.1685 - 1688, 2012/06
Times Cited Count：5 Percentile：22.76(Physics, Condensed Matter)Sn cable-in-conduit conductorsHemmi, Tsutomu; Harjo, S.; Ito, Takayoshi; Matsui, Kunihiro; Nunoya, Yoshihiko; Koizumi, Norikiyo; Takahashi, Yoshikazu; Nakajima, Hideo; Aizawa, Kazuya; Suzuki, Hiroshi; et al.
IEEE Transactions on Applied Superconductivity, 21(3), p.2028 - 2031, 2011/06
Times Cited Count：10 Percentile：49.04(Engineering, Electrical & Electronic)Residual strain in conductors is caused by the difference in the coefficient of expansion between NbSn strands and the jacket over a temperature range of 5 - 923 K. The superconducting properties of strands vary significantly, depending on the strain. It is important to clarify the residual strain as part of the evaluation of superconducting performance. However, the residual strain of strands in the conductor has not been measured so far because of their complicated configuration and their location in a jacket. The engineering materials diffractometer "Takumi" in J-PARC can measure residual strain with a relative accuracy of around 0.02%, using neutron diffraction. In this study, the Takumi was applied to the measurement of residual strain in strands for the ITER TF conductor. Results indicate that the residual strain of strands in the conductor can be determined, thereby clarifying the mechanism of residual strain and its relationship to superconducting performance.
Ito, Takayoshi; Harjo, S.; Osamura, Kozo*; Hemmi, Tsutomu; Awaji, Satoshi*; Machiya, Shutaro*; Oguro, Hidetoshi*; Nishijima, Gen*; Takahashi, Koki*; Matsui, Kunihiro; et al.
Materials Science Forum, 681, p.209 - 214, 2011/05
Times Cited Count：1 Percentile：50.83(Materials Science, Multidisciplinary)Imai, Yoshinori*; Takahashi, Hideyuki*; Kitagawa, Kentaro*; Matsubayashi, Kazuyuki*; Nakai, Noriyuki*; Nagai, Yuki; Uwatoko, Yoshiya*; Machida, Masahiko; Maeda, Atsutaka*
Journal of the Physical Society of Japan, 80(1), p.013704_1 - 013704_4, 2011/01
Times Cited Count：36 Percentile：80.98(Physics, Multidisciplinary)no abstracts in English
Tanaka, Kazuya; Tani, Yukinori*; Takahashi, Yoshio*; Tanimizu, Masaharu*; Suzuki, Yoshinori*; Kozai, Naofumi; Onuki, Toshihiko
Geochimica et Cosmochimica Acta, 74(19), p.5463 - 5477, 2010/10
Times Cited Count：99 Percentile：89.83(Geochemistry & Geophysics)We carried out sorption experiments of Ce by biogenic Mn oxide produced by a Mn(II)-oxidizing fungus strain KR21-2. The results of the sorption experiments indicated that Ce(III) was oxidized to Ce(IV) by biogenic Mn oxide in solution with pH 3.8 - 7. Furthermore, oxidized Ce(IV) by biogenic Mn oxide was complexed with organic ligands released from fungal cells under circumneutral conditions.
Yanagie, Hironobu*; Kumada, Hiroaki*; Nakamura, Takemi; Higashi, Shushi*; Ikushima, Ichiro*; Morishita, Yasuyuki*; Shinohara, Atsuko*; Fujiwara, Mitsuteru*; Suzuki, Minoru*; Sakurai, Yoshinori*; et al.
Proceedings of 14th International Congress on Neutron Capture Therapy (ICNCT-14) (CD-ROM), p.157 - 160, 2010/10
Tobita, Kenji; Nishio, Satoshi*; Enoeda, Mikio; Nakamura, Hirofumi; Hayashi, Takumi; Asakura, Nobuyuki; Uto, Hiroyasu; Tanigawa, Hiroyasu; Nishitani, Takeo; Isono, Takaaki; et al.
JAEA-Research 2010-019, 194 Pages, 2010/08
JAEA-Research-2010-019-01.pdf:48.47MBJAEA-Research-2010-019-02.pdf:19.4MB
This report describes the results of the conceptual design study of the SlimCS fusion DEMO reactor aiming at demonstrating fusion power production in a plant scale and allowing to assess the economic prospects of a fusion power plant. The design study has focused on a compact and low aspect ratio tokamak reactor concept with a reduced-sized central solenoid, which is novel compared with previous tokamak reactor concept such as SSTR (Steady State Tokamak Reactor). The reactor has the main parameters of a major radius of 5.5 m, aspect ratio of 2.6, elongation of 2.0, normalized beta of 4.3, fusion out put of 2.95 GW and average neutron wall load of 3 MW/m
. This report covers various aspects of design study including systemic design, physics design, torus configuration, blanket, superconducting magnet, maintenance and building, which were carried out increase the engineering feasibility of the concept.
Kakinouchi, Keisuke*; Nakamura, Tsutomu*; Tamada, Taro; Adachi, Hiroaki*; Sugiyama, Shigeru*; Maruyama, Mihoko*; Takahashi, Yoshinori*; Takano, Kazufumi*; Murakami, Satoshi*; Inoue, Tsuyoshi*; et al.
Journal of Applied Crystallography, 43(4), p.937 - 939, 2010/08
Times Cited Count：4 Percentile：47.68(Chemistry, Multidisciplinary)A method for growing large protein crystals is described. In this method, a cut pipette tip is used to hang large-scale droplets (maximum volume 200 
l) consisting of protein and precipitating agents. A crystal grows at the vapor-liquid interface; thereafter the grown crystal can be retrieved by droplet-droplet contact both for repeated macroseeding and for mounting crystals in a capillary. Crystallization experiments with peroxiredoxin of 
K1(thioredoxin peroxidase, ApTPx) and hen egg white lysozyme demonstrated that this large-scale hanging-drop method could produce a large-volume crystal very effectively. A neutron diffraction experiment confirmed that an ApTPx crystal (6.2 mm
) obtained by this method diffracted to beyond 3.5 
resolution.
resolutionShimizu, Noriko*; Sugiyama, Shigeru*; Maruyama, Mihoko*; Takahashi, Yoshinori*; Adachi, Motoyasu; Tamada, Taro; Hidaka, Koshi*; Hayashi, Yoshio*; Kimura, Toru*; Kiso, Yoshiaki*; et al.
Crystal Growth & Design, 10(7), p.2990 - 2994, 2010/06
Times Cited Count：11 Percentile：71.39(Chemistry, Multidisciplinary)We report crystal growth of human immunodeficiency virus 1 protease (HIV PR) in a complex with its inhibitor KNI-272 by six different methods. Comparative analysis indicates that top-seeded solution growth (TSSG) and TSSG combined with the floating and stirring technique (TSSG-FAST) are efficient strategies for rapidly obtaining large single crystals and effectively preventing polycrystallization of the seed crystal. Neutron diffraction analysis confirmed that the crystalobtained by TSSG is a high-quality single crystal. Furthermore, crystal shape was observed to be influenced by solution flow, suggesting that the degree of supersaturation significantly affects the crystal growth direction of HIV PR complex. This finding implies that the shape of the HIV PR complex crystal might be controlled by the solution flow rate.
Matsui, Yoshinori; Takahashi, Hiroyuki; Yamamoto, Masaya; Nakata, Masahito; Yoshitake, Tsunemitsu; Abe, Kazuyuki; Yoshikawa, Katsunori; Iwamatsu, Shigemi; Ishikawa, Kazuyoshi; Kikuchi, Taiji; et al.
JAEA-Technology 2009-072, 144 Pages, 2010/03
JAEA-Technology-2009-072.pdf:45.01MB
"R&D Project on Irradiation Damage Management Technology for Structural Materials of Long-life Nuclear Plant" was carried out from FY2006 in a fund of a trust enterprise of the Ministry of Education, Culture, Sports, Science and Technology. The coupled irradiations or single irradiation by JOYO fast reactor and JRR-3 thermal reactor were performed for about two years. The irradiation specimens are very important materials to establish of "Evaluation of Irradiation Damage Indicator" in this research. For the acquisition of the examination specimens irradiated by the JOYO and JRR-3, we summarized about the overall plan, the work process and the results for the study to utilize these reactors and some facilities of hot laboratory (WASTEF, JMTR-HL, MMF and FMF) of the Oarai Research-and-Development Center and the Nuclear Science Research Institute in the Japan Atomic Energy Agency.
Tobita, Kenji; Nishio, Satoshi; Enoeda, Mikio; Kawashima, Hisato; Kurita, Genichi; Tanigawa, Hiroyasu; Nakamura, Hirofumi; Honda, Mitsuru; Saito, Ai*; Sato, Satoshi; et al.
Nuclear Fusion, 49(7), p.075029_1 - 075029_10, 2009/07
Times Cited Count：141 Percentile：97.57(Physics, Fluids & Plasmas)Recent design study on SlimCS focused mainly on the torus configuration including blanket, divertor, materials and maintenance scheme. For vertical stability of elongated plasma and high beta access, a sector-wide conducting shell is arranged in between replaceable and permanent blanket. The reactor adopts pressurized-water-cooled solid breeding blanket. Compared with the previous advanced concept with supercritical water, the design options satisfying tritium self-sufficiency are relatively scarce. Considered divertor technology and materials, an allowable heat load to the divertor plate should be 8 MW/m or lower, which can be a critical constraint for determining a handling power of DEMO (a combination of alpha heating power and external input power for current drive).
Okuno, Hiroshi; Suyama, Kenya; Takahashi, Satoshi*; Watanabe, Shoichi*; Tonoike, Kotaro; Miyoshi, Yoshinori
Transactions of the American Nuclear Society, 95(1), p.283 - 284, 2006/11
no abstracts in English
Yura, Kei; Shionyu, Masafumi*; Hagino, Kei*; Hijikata, Atsushi*; Hirashima, Yoshinori*; Nakahara, Taku*; Eguchi, Tatsuya*; Shinoda, Kazuki*; Yamaguchi, Akihiro*; Takahashi, Kenichi*; et al.
Gene, 380(2), p.63 - 71, 2006/10
Times Cited Count：56 Percentile：71.98(Genetics & Heredity)Alternative splicing is a molecular mechanism that produces multiple proteins from a single gene, and is thought to produce variety in proteins translated from a limited number of genes. Here we analyzed how alternative splicing produced variety in protein structure and function, by using human full-length cDNAs, on the assumption that all of the alternatively spliced mRNAs were translated to proteins. We found that the length of alternatively spliced amino acid sequences, in most cases, fell into a size shorter than that of average protein domain. We evaluated comprehensively the presumptive three-dimensional structures of the alternatively spliced products to assess the impact of alternative splicing on gene function. We found that more than half of the products encoded proteins which were involved in signal transduction, transcription and translation, and more than half of alternatively spliced regions comprised interaction sites between proteins and their binding partners, including substrates, DNA/RNA, and other proteins. Intriguingly, 67% of the alternatively spliced isoforms showed significant alterations to regions of the protein structural core, which likely resulted in large conformational change. Based on those findings, we speculate that there are a large number of cases that alternative splicing modulates protein networks through significant alteration in protein conformation.
Ishikawa, Masayori*; Ono, Koji*; Matsumura, Akira*; Yamamoto, Tetsuya*; Hiratsuka, Junichi*; Miyatake, Shinichi*; Kato, Itsuro*; Sakurai, Yoshinori*; Kobayashi, Toru*; Kumada, Hiroaki; et al.
Proceedings of 12th International Congress on Neutron Capture Therapy (ICNCT-12), p.397 - 400, 2006/10
An ultraminiature thermal neutron monitor which was named SOF detector (Scintillator with Optical Fiber detector) had been developed for BNCT treatment. We had been experienced 15 clinical trials using SOF detector until the end of 2005, some measurements got good results, and some got unacceptable results. One reason of the unacceptable results was due to dislocation of the detector during treatment. This is because it is difficult to fix the SOF detector on patient's skin without strong sticker. To overcome this problem, a loop-type SOF probe was developed. By using the loop-type SOF detector, fixing on the patient's skin was much easier.
Kashiwa, Yoshinori*; Saigusa, Mikio*; Takahashi, Koji; Kasugai, Atsushi; Sakamoto, Keishi
Fusion Engineering and Design, 81(19), p.2249 - 2256, 2006/09
Times Cited Count：4 Percentile：29.92(Nuclear Science & Technology)High efficiency ECCD operations need an obliquely propagating electromagnetic wave with a specified elliptical polarization in magnetized plasma. The polarizer is necessary in order to excite the specified polarization. In the ITER design for ECCD system, the transmitted power per one waveguide is planned to be 1 MW as CW operation. The ohmic loss evaluation code for grooved mirror polarizers which calculates tangential magnetic field to the material at exterior to the groove and inside of that was developed. Calculation results were made sure of agreement with high power experiment qualitatively, and validity of the evaluation code has been confirmed.
Saigusa, Mikio*; Takahashi, Koji; Kashiwa, Yoshinori*; Oishi, Shimpei*; Hoshi, Yuki*; Nakahata, Hiroyuki*; Kasugai, Atsushi; Sakamoto, Keishi; Imai, Tsuyoshi*
Fusion Engineering and Design, 74(1-4), p.473 - 478, 2005/11
Times Cited Count：4 Percentile：29.82(Nuclear Science & Technology)The specification of an electron cyclotron current driving (ECCD) system in International Thermonuclear Experimental Reactor (ITER) demands severe operational conditions for transmission lines and polarizers. For evaluating Ohmic loss of a miter bend type polarizer, the six polarizers were made of chromium copper alloy, installed in miter bends and tested at a frequency of 170GHz, rf power of 441kW and pulse duration of 0.1-6 seconds. The increase in temperature on the back of the grooved mirrors has been measured with thermo couplers during high power rf pulses. The Ohmic loss of grooved mirrors strongly depends on the rotation angle of the polarization plane of the incident waves and the mirror rotation in high power experiments, for example the Ohmic loss distributed from 0.2% to1.6%. The thermal analysis of grooved mirror has been performed with the 3D FEM code: FEVA. The all strange behavior of Ohmic loss of polarizers could be explained, theoretically.
Takahashi, Satoshi*; Okuno, Hiroshi; Miyoshi, Yoshinori
JAERI-Tech 2005-056, 51 Pages, 2005/09
JAERI-Tech-2005-056.pdf:2.92MB
In the heterogeneous system of the mixed oxide fuel of uranium and plutonium, hereafter, MOX fuel, it was investigated whether the system could be modeled as a homogeneous system on the conditions which dealt with the MOX fuel of particle diameter 0.02mm or less in MOX fuel fabrication facilities in Japan. The infinite multiplication factor of the homogeneous system of the MOX fuel was first calculated, and the optimum moderation condition over the each ratio of PuO
was determined. It was verified that carried out critical calculation for the heterogeneous system of the MOX fuel in which the spherical fuel diameter in a cube unit cell increased, and an atomic number ratio of hydrogen to heavy metal fixed conditions, and the probability for neutrons to escape resonance by a spherical fuel diameter no less than 0.1mm, and analyzed critical conditions etc. using a contiguous energy Monte Carlo code MVPII and JENDL3.3. The details of these calculations are reported. These results are expected to be quoted in a revised edition of "Nuclear Criticality Safety Handbook."
evaluation of BPA-Gd-DTPA complex as an MRI contrast agent and as a carrier for neutron capture therapyTakahashi, Kazunori*; Nakamura, Hiroyuki*; Furumoto, Shozo*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Fukuda, Hiroshi*; Yamamoto, Yoshinori*
Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 1 Pages, 2004/10
We synthesized a BPA-Gd-DTPA compound, as a carrier for neutron capture therapy to be used for MRI contrast media. Pinanediol was used as the protective group for B(OH)2 group of BPA, and the BPA unit was connected to the DTPA framework through an amide bond. The biodistribution studies were performed after injection of the compound into AH109A hepatoma bearing Donryu rats. The concentrations of Gd and boron were measured by prompt g-ray analyses. The tumor uptakes (% ID/g) were 1% and 0.3% at 20 min and 60 min after injection, respectively and were higher than that of carborane-Gd-DTPA, which we previously reported. However, liver and kidney uptake was very high and tumor/blood ratio was very low (0.38) compared to that of BPA itself (ca. 3.0). Alfa autoradiogram of a tumor bearing rat showed higher concentration of boron in the tumor compared to surrounding muscle and very high in the intestine. Although tumor selectivity of the compound was higher than that of carborane-Gd-DTPA, further studies of the synthesis and in vivo evaluation of better binary compounds are continuing.
Kashiwa, Yoshinori*; Saigusa, Mikio*; Takahashi, Koji; Oishi, Shimpei*; Hoshi, Yuki*; Kasugai, Atsushi; Sakamoto, Keishi; Imai, Tsuyoshi
Proceedings of 2004 International Symposium on Microwave Science and Its Application to Related Fields (Microwave 2004), p.527 - 530, 2004/07
An electron cyclotron current drive (ECCD) system is, especially, necessary to suppress the neoclassical tearing mode instability in ITER. The polarizers are one of the important components in the ECCD system, to generate optimum polarization for an efficient ECCD. An ohmic loss of the polarizers is evaluated, when 170GHz, high power RF wave taransmits, in oreder to investigate its performance. The maximum temperature increase on the back plate of the deep grooved and the conventinal type were 65
C and 30C, respectively. RF power and pulse were 441kW and 6sec, respectively. The dependence of temperature increase on the plolarizer angle obtained in the experiment agrees with the calculation, qualitatively. It was also found that the significant reduction of ohmic loss on the polarizers was achievable with the optimized rotation angle of the linearly polarized incident wave.
