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Journal Articles

Innate immune genes including a mucin-like gene, ${it mul-1}$, induced by ionizing radiation in ${it Caenorhabditis elegans}$

Kimura, Takafumi*; Takanami, Takako*; Sakashita, Tetsuya; Wada, Seiichi*; Kobayashi, Yasuhiko; Higashitani, Atsushi*

Radiation Research, 178(4), p.313 - 320, 2012/10

 Times Cited Count:8 Percentile:44.94(Biology)

Here, we found that exposure to ionizing radiation (IR) induce certain innate immune response gene of ${it mul-1}$ in the intestine. Pre-treatment with IR before seeding on ${it Pseudomonas aeruginosa}$ lawn plate, significantly increased survival rate in the nematode. IR induction of ${it mul-1}$ gene was highly dependent on the ELT-2 transcription factor and p38 MAPK. Moreover, the insulin/IGF-1 signal pathway works as an enhancer of induction of this gene. Silencing of the ${it mul-1}$ gene led to growth retardation after IR irradiation. Finally, we describe the cross-tolerance between the responses to radiation exposure and innate immune system.

Journal Articles

Radiation biology of ${it Caenorhabditis elegans}$; Germ cell response, aging and behavior

Sakashita, Tetsuya; Takanami, Takako*; Yanase, Sumino*; Hamada, Nobuyuki*; Suzuki, Michiyo; Kimura, Takafumi*; Kobayashi, Yasuhiko; Ishii, Naoaki*; Higashitani, Atsushi*

Journal of Radiation Research, 51(2), p.107 - 121, 2010/03

 Times Cited Count:31 Percentile:63.94(Biology)

The study of radiation effect in ${it Caenorhabditis (C.) elegans}$ have been carried out over three decades and now allow for understanding at the molecular, cellular and individual levels. This review describes the current knowledge of the biological effects of ionizing irradiation with a scope of the germ line, aging and behavior. ${it C. elegans}$ may be a good ${it in vivo}$ model system in the field of radiation biology.

Journal Articles

Effect of energetic heavy-ion irradiation on gene expression in ${it Caenorhabdits elegans}$

Higashitani, Atsushi*; Mori, Chihiro*; Kimura, Takafumi*; Ikenaga, Takahiko*; Takanami, Takako*; Sakashita, Tetsuya; Wada, Seiichi*; Hamada, Nobuyuki*; Kobayashi, Yasuhiko

JAEA-Review 2007-060, JAEA Takasaki Annual Report 2006, P. 112, 2008/03

We investigated the gene expression of ${it C. elegans}$ following carbon and $$gamma$$ irradiation using DNA microarray analysis. We observed the 187 and 297 upregulated genes after $$gamma$$ and carbon irradiation with 100 Gy, respectively, in which 51 genes were upregulated following both irradiations. On the other hand, the 358 and 388 genes were downregulated after $$gamma$$ and carbon irradiation, respectively.

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