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Journal Articles

Cross-scale analysis of temperature compensation in the cyanobacterial circadian clock system

Furuike, Yoshihiko*; Ouyang, D.*; Tominaga, Taiki*; Matsuo, Tatsuhito*; Mukaiyama, Atsushi*; Kawakita, Yukinobu; Fujiwara, Satoru*; Akiyama, Shuji*

Communications Physics (Internet), 5, p.75_1 - 75_12, 2022/04

Journal Articles

Influence of distant scatterer on air kerma measurement in the evaluation of diagnostic X-rays using Monte Carlo simulation

Tominaga, Masahide*; Nagayasu, Yukari*; Sasaki, Motoharu*; Furuta, Takuya; Hayashi, Hiroaki*; Oita, Masataka*; Nishiyama, Yuichi*; Haga, Akihiro*

Radiological Physics and Technology, 14(4), p.381 - 389, 2021/12

Due to recent advance of diagnostic radiology, the increase of diagnostic radiation exposure to patient becomes problem. Diagnostic Reference Levels has been released to optimized the radiation exposure to patients in Japan recently. The evaluation of entrance surface dose (ESD) is recommended to assess the dose level for general X-ray examination. The ESD can be easily evaluated by multiplying the backscatter factor of the patient body on the free-in-air air kerma. The air kerma free-in-air value used to estimate ESD may contain X-rays scattered from obstacles located at the time of measurement, which may induce non-minor error in assessments. We therefore studied the influence of scattered X-rays on air kerma measurement under various environments (distances, field sizes, and materials). It was found that the dependence on the X-ray energy and field size was different for different materials. The X-ray contamination can be ignored for all the materials when the distance to the scatterer exceeds 35 cm.

Journal Articles

Conformational dynamics of a multidomain protein by neutron scattering and computational analysis

Nakagawa, Hiroshi; Saio, Tomohide*; Nagao, Michihiro*; Inoue, Rintaro*; Sugiyama, Masaaki*; Ajito, Satoshi; Tominaga, Taiki*; Kawakita, Yukinobu

Biophysical Journal, 120(16), p.3341 - 3354, 2021/08

 Times Cited Count:0 Percentile:0.01(Biophysics)

A multi-domain protein can have various conformations in solution. Interactions with other molecules result in the stabilization of one of the conformations and change in the domain dynamics. SAXS, a well-established experimental technique, can be employed to elucidate the conformation of a multi-domain protein in solution. NSE spectroscopy is a promising technique for recording the domain dynamics in nanosecond and nanometer scale. Despite the great efforts, there are still under development. Thus, we quantitatively removed the contribution of diffusion dynamics and hydrodynamic interactions from the NSE data via incoherent scattering, revealing the differences in the domain dynamics of the three functional states of a multi-domain protein, MurD. The differences among the three states can be explained by two domain modes.

Journal Articles

Corrosion of aluminum-based containers for neutron studies with aqueous samples under low temperatures

Tominaga, Taiki*; Sahara, Masae*; Kawakita, Yukinobu; Nakagawa, Hiroshi; Shimamoto, Naonobu*

JPS Conference Proceedings (Internet), 33, p.011094_1 - 011094_5, 2021/03

In quasielastic neutron scattering studies, aluminum or aluminum alloys are frequently employed as sample cells. With the increasing incident-neutron flux, the research area currently continues to expand; thus, obtaining data has become quicker than ever for dilute conditions. One such area is the water-containing systems. In this study, we investigated the effect of temperature on Al and found that even in a low temperature atmosphere, Al corrosion can occur. This was attributed to the different thermal expansion coefficients of Al as a base substrate and Al oxide as a passivating film.

Journal Articles

Position dependency of the scattered intensity in the time-of-flight backscattering spectrometer DNA

Matsuura, Masato*; Yamada, Takeshi*; Tominaga, Taiki*; Kobayashi, Makoto*; Nakagawa, Hiroshi; Kawakita, Yukinobu

JPS Conference Proceedings (Internet), 33, p.011068_1 - 011068_6, 2021/03

The position dependence of the scattered intensity in the time-of-flight backscattering spectrometer DNA was investigated. A periodic structure for both vertical (pixel) and horizontal (PSD) directions was observed. The solar slit and over-bending of an analyzer crystal is discussed as a possible origin of the modulation in the intensity. We have developed software program for the systematic correction of the position-dependent intensity and offset energy for the elastic peak. This corrects the deviation from the true scattering intensity and improve the quality of the data, which includes the energy resolution.

Journal Articles

Position-encoded automatic cell elevator for BL02, J-PARC MLF

Tominaga, Taiki*; Kobayashi, Makoto*; Yamada, Takeshi*; Matsuura, Masato*; Kawakita, Yukinobu; Kasai, Satoshi*

JPS Conference Proceedings (Internet), 33, p.011095_1 - 011095_5, 2021/03

A vertical movement type of sample changer for the neutron spectrometer BL02, J-PARC MLF was developed for our top-loading type cryostat. The sample changer, termed as "PEACE", can control reproducibility of the irradiated position using guides made of polyether ether ketone. The variation between the background scattering profiles of three sample positions was found to be less than plus minus 1.6%. This result is reasonable, considering the deviation of sample position of less than plus minus 0.3 mm from the vertical axis.

Journal Articles

Quartz cell for a backscattering spectrometer

Tominaga, Taiki*; Kawakita, Yukinobu; Nakagawa, Hiroshi; Yamada, Takeshi*; Shibata, Kaoru

JPS Conference Proceedings (Internet), 33, p.011086_1 - 011086_5, 2021/03

We developed a quartz double cylindrical sample cell optimized for a backscattering neutron spectrometer, especially for BL02 (DNA), MLF in J-PARC. A quartz glass tube, with one end closed, is shaved to obtain a wall thickness of 0.55 mm. The inner tube is properly centered using a protrusion into the outer tube such that the interstice between the outer and inner tubes keeps constant. This quartz cell can be used for samples that should not be in contact with the aluminum surface. We verified cell's background effect between the quartz cell and Al cell by QENS measurements using D$$_{2}$$O buffer. The elastic intensity profiles of the buffer in a low Q region were identical between both quartz cell and Al cell (A1070). In a high Q region, however, the profiles were different caused by the first sharp diffraction peak of quartz glass. For this region the data should be analyzed by consideration of absorption correction and diffraction in individual thickness of quartz cell.

Journal Articles

Dynamics of proteins with different molecular structures under solution condition

Inoue, Rintaro*; Oda, Takashi*; Nakagawa, Hiroshi; Tominaga, Taiki*; Saio, Tomohide*; Kawakita, Yukinobu; Shimizu, Masahiro*; Okuda, Aya*; Morishima, Ken*; Sato, Nobuhiro*; et al.

Scientific Reports (Internet), 10, p.21678_1 - 21678_10, 2020/12

 Times Cited Count:0 Percentile:0(Multidisciplinary Sciences)

Incoherent quasielastic neutron scattering (iQENS) is a fascinating technique for investigating the internal dynamics of protein. However, both low flux of neutron beam and absence of analytical procedure for extracting the internal dynamics from iQENS profile have been obstacles for studying it under physiological condition (in solution). Thanks to the recent development of neutron source, spectrometer and computational technique, they enable us to decouple internal dynamics, translational and rotational diffusions from the iQENS profile. The internal dynamics of two proteins: globular domain protein (GDP) and intrinsically disordered protein (IDP) in solution were studied. It was found that the average relaxation rate of IDP was larger than that of GDP. Through the detailed analyses on their internal dynamics, it was revealed that the fraction of mobile H atoms in IDP was much higher than that in GDP. Interestingly, the fraction of mobile H atoms was closely related to the fraction of H atoms on highly solvent exposed surfaces. The iQENS study presented that the internal dynamics were governed by the highly solvent exposed amino acid residues depending upon protein molecular architectures.

Journal Articles

Anomalous small-angle X-ray scattering (ASAXS) study of irradiation-induced nanostructure change in Fe-ion beam irradiated oxide dispersion-strengthened (ODS) steel

Kumada, Takayuki; Oba, Yojiro; Motokawa, Ryuhei; Morooka, Satoshi; Tominaga, Aki; Tanida, Hajime; Shobu, Takahisa; Konno, Azusa; Owada, Kenji*; Ono, Naoko*; et al.

Journal of Nuclear Materials, 528, p.151890_1 - 151890_7, 2020/01

 Times Cited Count:0 Percentile:0.01(Materials Science, Multidisciplinary)

We have developed an anomalous small-angle X-ray scattering (ASAXS) diffractometer in SPring-8 to investigate irradiation-induced nanostructural change in ion-beam irradiated stainless steel. A thermally-aged MA956 stainless steel sample displays power-law scattering that follows the Porod law at the magnitude of scattering vector, Q, below 0.5 nm$$^-1$$ and an overlapped shoulder around 0.7 nm$$^-1$$. After the ion-beam irradiation, the intensity of the shoulder remained unchanged, whereas that of the power-law scattering nearly doubled. This result indicates that none of the structural parameters of the Cr-rich nanoprecipitates, such as the number density, size, and interface roughness, were changed by the irradiation.

Journal Articles

Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer

Toyoda, Minoru*; Kaira, Kyoichi*; Ohshima, Yasuhiro; Ishioka, Noriko; Shino, Masato*; Sakakura, Koichi*; Takayasu, Yukihiro*; Takahashi, Katsumasa*; Tominaga, Hideyuki*; Oriuchi, Noboru*; et al.

British Journal of Cancer, 110(10), p.2506 - 2513, 2014/05

 Times Cited Count:89 Percentile:95.79(Oncology)

Journal Articles

Biological significance of fluorine-18-$$alpha$$-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer

Suzuki, Shigemasa*; Kaira, Kyoichi*; Ohshima, Yasuhiro; Ishioka, Noriko; Soda, Makoto*; Yokobori, Takehiko*; Miyazaki, Tatsuya*; Oriuchi, Noboru*; Tominaga, Hideyuki*; Kanai, Yoshikatsu*; et al.

British Journal of Cancer, 110(8), p.1985 - 1991, 2014/04

 Times Cited Count:20 Percentile:61.85(Oncology)

Journal Articles

Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

Kaira, Kyoichi*; Sunose, Yutaka*; Ohshima, Yasuhiro; Ishioka, Noriko; Arakawa, Kazuhisa*; Ogawa, Tetsushi*; Sunaga, Noriaki*; Shimizu, Kimihiro*; Tominaga, Hideyuki*; Oriuchi, Noboru*; et al.

BMC Cancer, 13, p.482_1 - 482_12, 2013/10

 Times Cited Count:51 Percentile:85.76(Oncology)

Journal Articles

Predicting cetuximab accumulation in ${it KRAS}$ wild-type and ${it KRAS}$ mutant colorectal cancer using $$^{64}$$Cu-labeled cetuximab positron emission tomography

Achmad, A.*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Yamamoto, Shinji*; Tominaga, Hideyuki*; Araki, Takuya*; Ohshima, Yasuhiro; Oriuchi, Noboru*; Endo, Keigo*

Cancer Science, 103(3), p.600 - 605, 2012/03

 Times Cited Count:20 Percentile:53.71(Oncology)

Journal Articles

Influence of a fault system on rock mass response to shaft excavation in soft sedimentary rock, Horonobe area, northern Japan

Tokiwa, Tetsuya; Tsusaka, Kimikazu; Ishii, Eiichi; Sanada, Hiroyuki; Tominaga, Eiji*; Hatsuyama, Yoshihiro*; Funaki, Hironori

International Journal of Rock Mechanics and Mining Sciences, 48(5), p.773 - 781, 2011/07

 Times Cited Count:12 Percentile:72.29(Engineering, Geological)

This paper focuses attention on stress field that produced fault system, and presents an example of the relationship between fault system and rock mass response to shaft excavation in soft sedimentary rocks in the Horonobe area, Japan. The directions determined by fault-slip analysis are close to the direction of maximum and minimum diameter reduction in the shaft. The results show that fault system can affects rock mass response to shaft excavation in soft rock and furthermore, and it is considered that the rock mass deformation was controlled by fault system. In addition, it is likely that we can assess and predict rock mass behavior by focusing on palaeo-stress field that produced fault system.

Journal Articles

Chemical abundances in the secondary star of the black hole binary V4641 Sagittarii (SAX J1819.3-2525)

Sadakane, Kozo*; Arai, Akira*; Aoki, Wako*; Arimoto, Nobuo*; Hidai, Masahide*; Onishi, Takashi*; Tajitsu, Akito*; Beers, T. C.*; Iwamoto, Nobuyuki; Tominaga, Nozomu*; et al.

Publications of the Astronomical Society of Japan, 58(3), p.595 - 604, 2006/06

 Times Cited Count:10 Percentile:31.51(Astronomy & Astrophysics)

We report detailed spectroscopic studies performed for the secondary star in the black hole binary (micro-quasar) V4641 Sgr in order to examine its surface chemical composition and to see if its surface shows any signature of pollution by ejecta from a supernova explosion. We obtain abundances of 10 elements and find definite over-abundances of N (by 0.8 dex or more) and Na (by 0.8 dex) in V4641 Sgr. From line-by-line comparisons of eight other elements (C, O, Mg, Al, Si, Ti, Cr, Fe) between V4641 Sgr and the two normal late B-type stars, which have been reported to have solar abundances. An evolutionary model of a massive close binary system has been constructed to explain the abundances observed in V4641 Sgr. The model suggests that the BH forming supernova in this system was a dark one.

Journal Articles

Study of carbon deposition effect on hydrogen permeation through palladium membrane

Tominaga, Shinya*; Busnyuk, A.*; Matsushima, T.*; Yamaguchi, Kenji; Ono, Futaba*; Terai, Takayuki*; Yamawaki, Michio*

Fusion Science and Technology, 41(3), p.919 - 923, 2002/05

no abstracts in English

Journal Articles

Economic scale of utilization of nuclear

Takehisa, Masaaki*; Tagawa, Seiichi*; Kashiwagi, Masayuki*; Tominaga, Hiroshi*; Ishikawa, Isamu*; Ooka, Norikazu; Kamada, Toshimitsu*; Hosobuchi, Kazunari*; Makuuchi, Keizo; Takeshita, Hidefumi; et al.

Genshiryoku Riyo No Keizai Kibo; NSA/Commentaries, No.9, 139 Pages, 2001/01

no abstracts in English

JAEA Reports

Characterization of fission products in hull

Saito, Kenya*; Kakuta, Akio*; Oi, Noboru*; Nomata, Terumitsu*; Tominaga, Yasuo*; Okoshi, Yoshimi*; Kashibe, Shinji*; Ouchi, Atsuhiro*

PNC TJ4164 88-002VOL2, 24 Pages, 1988/05



JAEA Reports

Characterization of fission products in hull

Saito, Kenya*; Kakuta, Akio*; Oi, Noboru*; Nomata, Terumitsu*; Tominaga, Yasuo*; Okoshi, Yoshimi*; Kashibe, Shinji*; Ouchi, Atsuhiro*

PNC TJ4164 88-002VOL1, 60 Pages, 1988/05



Journal Articles

Nondestructive elememtal analysis by the method of neutron resonance absorption

Ishikawa, Isamu; Tachikawa, Noboru; Okubo, Makio; Tominaga, Hiroshi

Transactions of the American Nuclear Society, 56(SUPPL.3), p.31 - 32, 1988/00

no abstracts in English

58 (Records 1-20 displayed on this page)