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Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.
Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01
Times Cited Count：10 Percentile：91.34(Multidisciplinary Sciences)Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.
Yamada, Kazuo*; Maruyama, Ippei*; Haga, Kazuko*; Igarashi, Go*; Aihara, Haruka; Tomita, Sayuri*; Kiran, R.*; Osawa, Norihisa*; Shibata, Atsuhiro; Shibuya, Kazutoshi*; et al.
Proceedings of International Waste Management Symposia 2021 (WM2021) (CD-ROM), 10 Pages, 2021/03
Ueda, Yoshio*; Oya, Kaoru*; Ashikawa, Naoko*; Ito, Atsushi*; Ono, Tadayoshi*; Kato, Daiji*; Kawashima, Hisato; Kawamura, Gakushi*; Kenmotsu, Takahiro*; Saito, Seiki*; et al.
Purazuma, Kaku Yugo Gakkai-Shi, 88(9), p.484 - 502, 2012/09
no abstracts in English
Oya, Kaoru*; Inai, Kensuke*; Shimizu, Katsuhiro; Takizuka, Tomonori; Kawashima, Hisato; Hoshino, Kazuo; Hatayama, Akiyoshi*; Toma, Mitsunori*; Tomita, Yukihiro*; Kawamura, Gakushi*; et al.
Purazuma, Kaku Yugo Gakkai-Shi, 85(10), p.695 - 703, 2009/10
no abstracts in English
Minato, Kazuo; Sawa, Kazuhiro; Koya, Toshio; Tomita, Takeshi; Ishikawa, Akiyoshi; Baldwin, C. A.*; Gabbard, W. A.*; Malone, C. M.*
Nuclear Technology, 131(1), p.36 - 47, 2000/07
Times Cited Count：57 Percentile：94.74(Nuclear Science & Technology)no abstracts in English
Minato, Kazuo; Ogawa, Toru; Koya, Toshio; Sekino, Hajime; Tomita, Takeshi
Journal of Nuclear Materials, 279(2-3), p.181 - 188, 2000/06
Times Cited Count：34 Percentile：87.87(Materials Science, Multidisciplinary)no abstracts in English
Minato, Kazuo; Ogawa, Toru; Sawa, Kazuhiro; Ishikawa, Akiyoshi; Tomita, Takeshi; Iida, Shozo; Sekino, Hajime
Nuclear Technology, 130(3), p.272 - 281, 2000/06
Times Cited Count：71 Percentile：96.73(Nuclear Science & Technology)no abstracts in English
Minato, Kazuo; Ogawa, Toru; Sawa, Kazuhiro; Sekino, Hajime; Koya, Toshio; Kitagawa, Isamu; Ishikawa, Akiyoshi; Tomita, Takeshi;
Proc. of the Int. Conf. on Future Nuclear Systems (GLOBAL'99)(CD-ROM), 8 Pages, 1999/00
no abstracts in English
Nishi, Tsuyoshi; Takano, Masahide; Ito, Akinori; Akabori, Mitsuo; Minato, Kazuo; Tomita, Takeshi; Numata, Masami
no journal, ,
no abstracts in English
Ohara, Takashi; Kusaka, Katsuhiro*; Hosoya, Takaaki; Kurihara, Kazuo; Tomoyori, Katsuaki*; Niimura, Nobuo*; Tanaka, Ichiro*; Suzuki, Jiro*; Nakatani, Takeshi; Otomo, Toshiya*; et al.
no journal, ,
For a single crystal diffractometer, a data reduction software which extracts a HKLF list from the raw data is one of the most important components. We are now developing a new data reduction software for a new single crystal neutron diffractometer, "IBARAKI Biological Crystal Diffractometer (iBIX)", which is now constructing at the MLF of J-PARC.
Ohara, Takashi; Kusaka, Katsuhiro*; Hosoya, Takaaki*; Kurihara, Kazuo; Tomoyori, Katsuaki*; Niimura, Nobuo*; Tanaka, Ichiro*; Suzuki, Jiro*; Nakatani, Takeshi; Otomo, Toshiya*; et al.
no journal, ,
no abstracts in English
Aihara, Haruka; Shibata, Atsuhiro; Koma, Yoshikazu; Tomita, Sayuri*; Yamada, Kazuo*; Maruyama, Ippei*
no journal, ,
no abstracts in English
Tomita, Sayuri*; Kobayashi, Yutaro*; Haga, Kazuko*; Hosokawa, Yoshifumi*; Yamada, Kazuo*; Aihara, Haruka; Igarashi, Go*; Maruyama, Ippei*
no journal, ,
no abstracts in English
Maruyama, Ippei*; Shibuya, Kazutoshi*; Tomita, Sayuri*; Igarashi, Go*; Koma, Yoshikazu; Yamada, Kazuo*
no journal, ,
no abstracts in English
Yamada, Kazuo*; Tojo, Yasumasa*; Tomita, Sayuri*; Aihara, Haruka; Igarashi, Go*; Hosokawa, Yoshifumi*; Maruyama, Ippei*
no journal, ,
no abstracts in English
Yamada, Kazuo*; Himori, Keita*; Tojo, Yasumasa*; Tomita, Sayuri*; Aihara, Haruka; Igarashi, Go*; Hosokawa, Yoshifumi*; Maruyama, Ippei*
no journal, ,
no abstracts in English
Yamada, Kazuo*; Tojo, Yasumasa*; Tomita, Sayuri*; Aihara, Haruka; Igarashi, Go*; Maruyama, Ippei*
no journal, ,
no abstracts in English
