Refine your search:     
Report No.
 - 
Search Results: Records 1-4 displayed on this page of 4
  • 1

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Journal Articles

Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage

Kataoka, Takahiro*; Nishiyama, Yuichi*; Toyota, Teruaki*; Yoshimoto, Masaaki*; Sakoda, Akihiro; Ishimori, Yuu; Aoyama, Yutaka*; Taguchi, Takehito*; Yamaoka, Kiyonori*

Inflammation, 34(6), p.559 - 567, 2011/12

 Times Cited Count:21 Percentile:49.67(Cell Biology)

We assessed whether radon inhalation provided protection from carbon tetrachloride induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl$$_{4}$$ after inhaling approximately 18 kBq/m$$^{3}$$ radon for 6 h. Radon inhalation significantly increased total glutathione content and glutathione peroxidase activity in the liver and kidney. Injection of CCl$$_{4}$$ was associated with significantly higher levels of glutamic oxaloacetic transaminase and alkaline phosphatase activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl$$_{4}$$ injection, suggesting that radon inhalation alleviates CCl$$_{4}$$-induced hepatic and renal damage. The t-GSH contents an GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl$$_{4}$$-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl$$_{4}$$-induced hepatic and renal damage in mice.

Journal Articles

A Comparative study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damages of liver and brain in mouse

Kataoka, Takahiro*; Sakoda, Akihiro*; Yoshimoto, Masaaki*; Toyota, Teruaki*; Yamamoto, Yuki*; Ishimori, Yuu; Hanamoto, Katsumi*; Kawabe, Atsushi*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Radiation Safety Management, 10(1), p.1 - 7, 2011/12

We examined the effect of continuous radon inhalation on acute alcohol-induced oxidative damage of mouse liver and brain. Assay of antioxidative functions indicated that lipid peroxide levels in both the liver and brain of the alcohol-treated mice were significantly higher than those of the saline-treated mice. However, the lipid peroxide level in the liver, but not in the brain, of alcohol-treated mice was significantly decreased by radon inhalation whereas that in the brain of saline-treated mice, but not in the liver of saline-treated mice, was significantly increased by radon inhalation. These findings suggest that radon inhalation inhibits alcohol-induced oxidative damage of liver due to activation of antioxidative functions and that radon inhalation exert only a week effect on the brains in comparing with the livers. They further suggest that alcohol administration protects against oxidative damage of the brain that is induced by radon inhalation.

Journal Articles

Study of the response of superoxide dismutase in mouse organs to radon using a new large-scale facility for exposing small animals to radon

Kataoka, Takahiro*; Sakoda, Akihiro; Ishimori, Yuu; Toyota, Teruaki*; Nishiyama, Yuichi*; Tanaka, Hiroshi; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Journal of Radiation Research, 52(6), p.775 - 781, 2011/11

 Times Cited Count:26 Percentile:67.38(Biology)

We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m$$^{3}$$ for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day Bq/m$$^{3}$$, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose-rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups ((1) plasma, brain, lung (2) heart, liver, pancreas, small intestine (3) kidney, thymus (4) stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.

Journal Articles

Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation

Kataoka, Takahiro*; Sakoda, Akihiro*; Yoshimoto, Masaaki*; Nakagawa, Shinya*; Toyota, Teruaki*; Nishiyama, Yuichi*; Yamato, Keiko*; Ishimori, Yuu; Kawabe, Atsushi*; Hanamoto, Katsumi*; et al.

Radiation Protection Dosimetry, 146(1-3), p.360 - 363, 2011/07

 Times Cited Count:6 Percentile:44.45(Environmental Sciences)

Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl$$_{4}$$) administration. Results showed that radon inhalation alleviates CCl$$_{4}$$-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.

4 (Records 1-4 displayed on this page)
  • 1