Production of iodine radionuclides using Li ion beams

Nishinaka, Ichiro*; Yokoyama, Akihiko*; Washiyama, Koshin*; Makii, Hiroyuki; Hashimoto, Kazuyuki*

Journal of Radioanalytical and Nuclear Chemistry, 314(3), p.1947 - 1965, 2017/12

https://doi.org/10.1007/s10967-017-5525-2

Production cross sections of iodine, tellurium and antimony radionuclides in the 24-59 MeV Li + Sn reaction have been measured by the conventional stacked foil technique with -ray spectrometry. Excitation functions of the production cross sections were compared with a statistical model calculation. The contributions of complete and incomplete fusion in the production of observed radionuclides are discussed from the view points of production routes in the nuclide chart and decays for iodine, tellurium and antimony nuclides. The integral yields of I were deduced from the calculated excitation functions in the Li induced reactions on Sn isotopes in view of the production of medically important I. The results are discussed by comparing with literature values in the other reactions.

Production and separation of astatine isotopes in the Li + Pb reaction

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Maeda, Eita*; Watanabe, Shigeki; Hashimoto, Kazuyuki; Ishioka, Noriko; Makii, Hiroyuki; Toyoshima, Atsushi; Yamada, Norihiro*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 304(3), p.1077 - 1083, 2015/06

https://doi.org/10.1007/s10967-015-3975-y

Production cross sections of astatine isotopes At in the 29-57 MeV Li induced reaction with Pb target have been measured by - and -ray spectrometry. Excitation functions of production cross sections have been compared with a statistical model calculation to study the reaction mechanism of Li + Pb. Considerably small experimental cross sections of At and At compared with the calculation were clearly observed at incident energies higher than 44 MeV, indicating that the effects of breakup reaction play a role. A chemical separation of astatine from an irradiated lead target has been studied with a dry-distillation method. A complementary way to produce astatine isotopes has been developed.

Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers

Shiga, Hideaki*; Taki, Junichi*; Washiyama, Koshin*; Yamamoto, Jumpei*; Kinase, Sakae; Okuda, Koichi*; Kinuya, Seigo*; Watanabe, Naoto*; Tonami, Hisao*; Koshida, Kichiro*; et al.

PLOS ONE (Internet), 8(2), p.e57671_1 - e57671_8, 2013/02

https://doi.org/10.1371/journal.pone.0057671

Photofission of Bi at intermediate energies

Haba, Hiromitsu; Kasaoka, Makoto*; Igarashi, Manabu*; Washiyama, Koshin*; Matsumura, Hiroshi*; Oura, Yasuji*; Shibata, Seiichi*; Sakamoto, Ko*; Furukawa, Michiaki*; Fujiwara, Ichiro*

Radiochimica Acta, 90(7), p.371 - 382, 2002/08

https://doi.org/10.1524/ract.2002.90.7_2002.371

The reaction yields of 63 radionuclides with the mass number A = 56-135 produced in the photofission of Bi by bremsstrahlung of end-point energies (E) from 450 to 1100 MeV have been measured using a catcher foil technique. The charge distribution was well reproduced by a Gaussian function with the most probable charge (Z) expressed by Z = RA + S, and with the A-independent FWHME. The charge distribution parameters R, S and FWHM were independent of E above 600 MeV. The weighted mean values at E 600 MeV were R = 0.421 0.001, S = 0.6 0.1 and FWHM = 2.1 0.1 charge unit (c.u.). Based on the charge distribution parameters, the symmetric mass yield distributions with the most probable mass A of 96 1 mass unit (m.u.) and the width FWHM of 33 1 m.u. were also obtained. The characteristics of the charge and mass yield distributions are discussed by referring to those for Au based on the results of calculations using PICA3/GEM.

Production of At for alpha radiotherapy via Bi(Li,5n)Rn

Nishinaka, Ichiro; Washiyama, Koshin*; Yokoyama, Akihiko*; Maeda, Eita*; Hashimoto, Kazuyuki; Makii, Hiroyuki

no journal, , 

A Rn/At generator has been proposed to supply a radiotracer At with a half-life (T = 7.2 h) for medical applications. To establish a technology of the Rn/At generator, Rn (T = 14.7 h) has to be produced through the Bi(Li, 5n)Rn reaction without melting bismuth metal targets due to heat produced by the irradiation of 60 MeV Li ion beams. In this work, we have studied the effects of a He gas cooling system of an irradiation chamber constructed for the production of Rn. Irradiations were carried out at the JAEA tandem accelerator using the irradiation chamber equipped with the He gas cooling system. The results show that the He gas effectively cools the targets and the cooling efficiency is nearly independent of the pressure ( 1 kPa) and the flow rate (20 L/min) of the He gas.

Nuclear and radiochemical study of production and utilization of radioactive astatine isotopes using lithium ion beams at the tandem accelerator of JAEA-Tokai

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Yamada, Norihiro*; Ishiguro, Rika*; Makii, Hiroyuki; Hashimoto, Kazuyuki

no journal, , 

An radioactive nuclide At is a prospective candidate for utilization in targeted alpha radiotherapy. We have started nuclear and radiochemical study of production and utilization of radioactive astatine isotopes using lithium ion beams at the tandem accelerator of JAEA-Tokai. We determined the excitation functions of astatine isotopes in the reaction of 29-48 MeV Li+Pb and studied a chemical behavior of carrier-free radioactive astatine isotopes with a dry-chemistry method. Details will be shown in the presentation.

Production of astatine radioisotopes in the Li+Pb reaction and simple chemical separation of astatine

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Ri, Keiko*; Yamada, Norihiro*; Ishiguro, Rika*; Maeda, Eita*; Makii, Hiroyuki; Hashimoto, Kazuyuki; et al.

no journal, , 

We have started to study production and utilization of an radioactive nuclide At which is a prospective candidate for targeted alpha radiotherapy. We determined production cross sections of astatine radioisotopes in the reaction of 29-48 MeV Li+Pb by -ray and -ray spectrometry at the tandem accelerator of JAEA-Tokai. Besides, we developed a simple dry-chemical method for separation of astatine.

Production and separation of radioactive astatine isotopes in the Li+Pb reaction

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yamada, Norihiro*; Makii, Hiroyuki; Toyoshima, Atsushi; Watanabe, Shigeki; Ishioka, Noriko; et al.

no journal, , 

To promote utilization of a radioactive nuclide At which draws increasing attention as a promissing -emitter for targeted alpha therapy, we have measured production cross sections of astatine isotopes in the 29-57 MeVLi+Pb reaction using the tandem accelerator of JAEA-Tokai, providing nuclear data for production. For pharmaceutical study and so on, beside, we have developed a new separation procedure based on a dry-distillation method which separates carrier free astatine isotopes from lead targets with high radiochemical and chemical purity and high yields.

Production of alpha-emitting radioisotopes using the cyclotron facilities at Osaka University and JAEA Takasaki, and the Tandem accelerator at Tokai, JAEA

Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yokoyama, Akihiko*; Nishinaka, Ichiro; Takahashi, Naruto*; Shinohara, Atsushi*; Watanabe, Shigeki; Ishioka, Noriko

no journal, , 

In order to use of an alpha emitter for targeted alpha therapy, we have started the production and the utilization of At using 30 MeV He particle in the Bi(He, 2n)At nuclear reaction at cyclotron facilities of Osaka University and JAEA Takasaki. In addition to that, we have been developing a Rn/At generator to expand the availability of At to wide range of populations far away from cyclotron facilities. The results of studies on the At-chemistry for clinical use and on the development of the Rn/At generator will be presented. And a review of current status of targeted alpha therapy in Japan will be also introduced.

Nuclear and radiochemical study of production and utilization of radioactive astatine isotopes in the Li + Pb reaction

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yamada, Norihiro*; Makii, Hiroyuki; Watanabe, Shigeki; Ishioka, Noriko; Hashimoto, Kazuyuki

no journal, ,