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Journal Articles

Technical estimation for mass production of highly-concentrated $$^{rm 99m}$$Tc solution from $$^{99}$$Mo to be obtained by ($$n,gamma$$) reaction; A Preliminary study using inactive Re instead of $$^{rm 99m}$$Tc

Tanase, Masakazu*; Fujisaki, Saburo*; Ota, Akio*; Shiina, Takayuki*; Yamabayashi, Hisamichi*; Takeuchi, Nobuhiro*; Tsuchiya, Kunihiko; Kimura, Akihiro; Suzuki, Yoshitaka; Ishida, Takuya; et al.

Radioisotopes, 65(5), p.237 - 245, 2016/05

no abstracts in English

Journal Articles

Preparation of polymer gel dosimeters based on less toxic monomers and gellan gum

Hiroki, Akihiro; Sato, Yuichi*; Nagasawa, Naotsugu; Ota, Akio*; Seito, Hajime; Yamabayashi, Hisamichi*; Yamamoto, Takayoshi*; Taguchi, Mitsumasa; Tamada, Masao; Kojima, Takuji

Physics in Medicine and Biology, 58(20), p.7131 - 7141, 2013/10

 Times Cited Count:15 Percentile:32.48(Engineering, Biomedical)

Journal Articles

Generation of radioisotopes with accelerator neutrons by deuterons

Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.

Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06

 Times Cited Count:25 Percentile:16.27(Physics, Multidisciplinary)

Journal Articles

Successful labeling of $$^{rm 99m}$$Tc-MDP using $$^{rm 99m}$$Tc separated from $$^{99}$$Mo produced by $$^{100}$$Mo($textit{n}$,2$textit{n}$)$$^{99}$$Mo

Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi*; Kawauchi, Yukimasa*; et al.

Journal of the Physical Society of Japan, 80(8), p.083201_1 - 083201_4, 2011/08

 Times Cited Count:10 Percentile:36.94(Physics, Multidisciplinary)

We have for the first time succeeded to separate $$^{rm 99m}$$Tc from a Mo oxide sample irradiated by accelerator neutrons, and to formulate $$^{rm 99m}$$Tc-methylene diphosphonate ($$^{rm 99m}$$Tc-MDP). $$^{99}$$Mo, the mother nuclide of $$^{rm 99m}$$Tc, was produced by the $$^{100}$$Mo($textit{n}$,2$textit{n}$)$$^{99}$$Mo reaction using about 14 MeV neutrons provided at the Fusion Neutronics Source of Japan Atomic Energy Agency. The $$^{rm 99m}$$Tc was separated from $$^{99}$$Mo by the sublimation method, and its radionuclide purity was confirmed to be higher than 99.99%. The labeling efficiency of $$^{rm 99m}$$Tc-MDP was shown to be higher than 99%. These values exceed the United States Pharmacopeia requirements for a fission product, $$^{99}$$Mo. Consequently, a $$^{rm 99m}$$Tc radiopharmaceutical preparation formed by using the mentioned $$^{99}$$Mo can be a promising substitute for the fission product $$^{99}$$Mo. A longstanding problem to ensure a reliable and constant supply of $$^{99}$$Mo in Japan can be partially mitigated.

JAEA Reports

Feasibility study of sublimation type $$^{99m}$$Tc master-milker; Comparison with PZC based wet method

Ishitsuka, Etsuo; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Norihito*; Hori, Naohiko; Awaludin, R.*; Gunawan, A. H.*; Lubis, H.*; Mutalib, A.*

JAEA-Technology 2011-019, 18 Pages, 2011/06

JAEA-Technology-2011-019.pdf:2.61MB

Feasibility study of sublimation type $$^{99m}$$Tc master-milker was carried out as a $$^{99}$$Mo/$$^{99m}$$T production development with the JMTR. As the feasibility study, the experimental equipment for sublimation method and wet method with PZC based $$^{99m}$$Tc solution were tentatively manufactured, and their properties as the master-milker were investigated by comparing two methods with each other. As a result, it was found that the $$^{99m}$$Tc recovery rate and process time of the sublimation method were about 80% and 1.5 hour, respectively, and the similar values were observed with the wet method. Superior points of the sublimation method are easier operation and reusability of the used MoO$$_{3}$$ comparing with the wet method. On the other hand, disadvantageous point is that the $$^{99m}$$Tc recovery rate decreases with the increase of treating amount of MoO$$_{3}$$.

JAEA Reports

Development of $$^{rm 99m}$$Tc extraction techniques from $$^{99}$$Mo by (n,$$gamma$$) reaction

Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Yuichi*

JAEA-Review 2010-053, 23 Pages, 2010/11

JAEA-Review-2010-053.pdf:2.52MB

Production techniques of $$^{99}$$Mo, parent nuclide of $$^{rm 99m}$$Tc, have been developed for the industrial utilization as medical diagnosis medicine after the JMTR refurbishment. The (n,$$gamma$$) method is proposed in JMTR because of low-amount radioactive wastes and easy $$^{rm 99m}$$Tc production process. In this study, the production of the high-density MoO$$_{3}$$ pellet and concentration techniques of $$^{rm 99m}$$Tc solution were developed. As the trial test, the MoO$$_{3}$$ pellets with high density were produced by the SPS (Spark Plasma Sintering) method. On the other hands, it was possible to concentrate $$^{rm 99m}$$Tc solution by the solvent extraction using Methyl Ethyl Ketone (MEK). From the result, the $$^{rm 99m}$$Tc concentrating device with more than 80% concentration efficiency, was performed successfully.

Journal Articles

Intra-organic change of trace elements in fetal development; Measurement by neutron activation analysis

Shin, Sumio*; Sato, Kiichi*; Nishida, Hiroshi*; Sakamoto, Shoichi*; Yamabayashi, Hisamichi; Motoki, Ryozo; Terunuma, Kusuo; Yamamoto, Takeo

Igaku No Ayumi, 140(1), p.51 - 52, 1987/01

Trace elements serve as key components of enzyme systems and have especially important correlation with fetal maturity.

Oral presentation

Refurbishment and restart of JMTR, 10; Technology development for attractive irradiation tests, 4; Extraction of $$^{99m}$$Tc from $$^{99}$$Mo produced by (n,$$gamma$$) method

Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Tanase, Masakazu*; Yamabayashi, Hisamichi*; Fujisaki, Saburo*; Sato, Yuichi*

no journal, , 

JP, 2009-264740   Patent publication (In Japanese)

To expand industrial utilization of JMTR to be reconstructed, JAEA has a plan to produce $$^{99}$$Mo (half life 65.9h), a parent nuclide of $$^{99m}$$Tc (half life 6.01h) which is used widely as radiopharmaceuticals. There are two methods for $$^{99}$$Mo production; the one is based on nuclear fission of $$^{235}$$U, and the other on neutron irradiation of natural Mo compounds. JAEA has proposed the latter method. On the other hand, the latter method also has some drawbacks that the specific activity of $$^{99}$$Mo and the concentration of $$^{99m}$$Tc in the product solution are very low. And so, to enhance the concentration of the $$^{99m}$$Tc, a method involving a process that the $$^{99m}$$Tc is extracted in methyl ethyl ketone (MEK) has proposed. In this paper, a fundamental study by using Re instead of $$^{99m}$$Tc is presented. Result, developed device can increase the concentration of $$^{99m}$$Tc solution by 20 times.

Oral presentation

Development of $$^{99m}$$Tc extraction techniques from $$^{99}$$Mo by (n,$$gamma$$) reaction

Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Yuichi*

no journal, , 

Production techniques of $$^{99}$$Mo, parent nuclide of $$^{99m}$$Tc, have been developed for the industrial utilization as medical diagnosis medicine after the JMTR refurbishment. The (n,$$gamma$$) method is proposed in JMTR because of low-amount radioactive wastes and easy $$^{99m}$$Tc production process. In this study, the production of the high-density MoO$$_{3}$$ pellet and concentration techniques of $$^{99m}$$Tc solution were developed. As the trial test, the MoO$$_{3}$$ pellets with high density were produced by the SPS (Spark Plasma Sintering) method. On the other hands, it was possible to concentrate $$^{99m}$$Tc solution by the solvent extraction using Methyl Ethyl Ketone (MEK). From the result, the $$^{99m}$$Tc concentrating device with more than 80% concentration efficiency, was performed successfully.

Oral presentation

Dose response characteristics of polymer gel using different monomers

Sato, Yuichi*; Hiroki, Akihiro; Ota, Akio*; Nagasawa, Naotsugu; Seito, Hajime; Iwanade, Akio; Yamabayashi, Hisamichi*; Yamamoto, Takayoshi*; Tamada, Masao; Kojima, Takuji

no journal, , 

no abstracts in English

10 (Records 1-10 displayed on this page)
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