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Journal Articles

Combination of boron and gadolinium compounds for neutron capture therapy; An $$in Vitro$$ study

Matsumura, Akira*; Zhang, T.*; Nakai, Kei*; Endo, Kiyoshi*; Kumada, Hiroaki; Yamamoto, Tetsuya*; Yoshida, Fumiyo*; Sakurai, Yoshinori*; Yamamoto, Kazuyoshi; Nose, Tadao*

Journal of Experimental and Clinical Cancer Research, 24(1), p.93 - 98, 2005/03

no abstracts in English

Journal Articles

Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect

Yoshida, Fumiyo*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki; Nakai, Kei*

Cancer Letters, 215(1), p.61 - 67, 2004/11

 Times Cited Count:13 Percentile:23.6(Oncology)

Sodium borocaptate (BSH) is widely used for Boron Neutron Capture Therapy (BNCT) of brain tumors. However, the mechanism of uptake by the tumor remains unclear. We investigated the sulfhydryl moiety of this compound. Down regulation of glutathione (GSH) by buthionine sulfoximine (BSO) in cultured cells resulted in increase of BSH uptake (7.9 %-36.5 %) compared to control group and subsequently cytocidal effect of neutron irradiation also increased. The radiation damage by $$gamma$$-ray irradiation was suppressed by enhancement of BSH uptake. These findings suggested that modulation of GSH induce enhancement effect of B(n,$$alpha$$) reaction and protective effect of secondary $$gamma$$-ray in BNCT.

Journal Articles

Analysis of intracellular distribution of boron and gadolinium in 9L sarcoma cells using a single-ended accelerator (Micro PIXE)

Endo, Kiyoshi*; Shibata, Yasushi*; Yoshida, Fumiyo*; Nakai, Kei*; Yamamoto, Tetsuya*; Matsumura, Akira*; Ishii, Keizo*; Sakai, Takuro; Sato, Takahiro; Oikawa, Masakazu*; et al.

Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 2 Pages, 2004/10

Micro PIXE, which is installed in a single end accelerator in JAERI, was used for quantitative analysis of boron and gadolinium distribution in a cell level. The micro beam of 1 $$mu$$m diameter is possible to observe the distribution. In the adjustment procedure of the sample, first is a fix of mylar film by using a glass ring and a bite ring of 2cm diameter. Next the 9L cells were scattered on the washed film, and is cultivated on 37$$^{circ}$$C in medium until they form the mono-layer. After the Gd-BOPTA was added, it incubates for the 24-72 hour on 37$$^{circ}$$C. The film is washed in the THAM liquid, and is directly put on liquid nitrogen. A vacuum drying for 24 hours is conducted in order to fix a film on holder. It is important to uniformly fix the cell in distribution analysis in the cell using Micro PIXE. In recent result, it became possible that the distribution of P, S, Gd, etc. was analyzed. But we could not distinguish whether K and Gd exist in the cell or whether it exists around the cell. It was indicated that these elements was leaked by the reason of cell breaking or other on the cytoplasm.

Journal Articles

In-air radiobiological dosimetry of JRR-4 neutron beams for boron neutron capture therapy

Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; Torii, Yoshiya; Endo, Kiyoshi*; Matsushita, Akira*; Yoshida, Fumiyo*; Shibata, Yasushi*; et al.

Research and Development in Neutron Capture Therapy, p.697 - 700, 2002/09

The RBE of dose components generated in boron neutron capture therapy (BNCT) were separately determined in neutron beams at JRR-4. The cell killing effect of the neutron beam with or without the presence of 10B was highly dependent on the neutron beam used, according to the epithermal and fast neutron content in the beam. RBE (BARBEboron) values of the boron capture reaction for an epithermal (ENB), a mixed thermal-epithermal (TNB-1), and a thermal (TNB-2) neutron beams were 3.99$$pm$$0.24, 3.04$$pm$$0.19 and 1.43$$pm$$0.08, respectively.

Journal Articles

A Combination use of boron and gadolinium compounds in ${it In vitro}$ NCT trial

Zhang, T.*; Matsumura, Akira*; Yamamoto, Tetsuya*; Yoshida, Fumiyo*; Sakurai, Yoshinori*; Kumada, Hiroaki; Yamamoto, Kazuyoshi; Nose, Tadao*

Research and Development in Neutron Capture Therapy, p.819 - 824, 2002/09

From present study, the irradiation effect by using combination of Boron and Gd, showed various irradiation effects (additive effect, less than additive effect, non additive effect), which depend on Gd concentration. The additive effect will be occurred when using a combination of Gd and Boron with low concentration, however, adding Gd to high concentration will reduce additive effect resulting in less than additive to finally non-additive effect. This result indicate that achieving suitable concentrations of Gd and Boron together in tumors may increase the therapy effect, but achieving excess concentration of Gd with Boron together in tumor may cause negative therapeuitic effect.

Journal Articles

Basic and clinical studies for application of epithermal neutron beam for neutron capture therapy

Nose, Tadao*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Yoshida, Fumiyo*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Matsushita, Akira*; Nakai, Kei*; Yamada, Takashi*; et al.

UTRCN-G-29, p.114 - 123, 2001/00

no abstracts in English

Journal Articles

None

Yoshida, Eiichi; ; Ueno, Fumiyoshi; Wada, Yusaku

Session II(1993), , 

None

Oral presentation

The Approach to the small animal experiment by new technique in JRR-4

Endo, Kiyoshi*; Nakai, Kei*; Yoshida, Fumiyo*; Shirakawa, Shin*; Yamamoto, Tetsuya*; Matsumura, Akira*; Sawahata, Hiroyuki*; kawate, Minoru*; Saito, Kimiaki; Kumada, Hiroaki; et al.

no journal, , 

no abstracts in English

Oral presentation

Visualization and distribution analysis of boron for boron neutron capture therapy with accelerator-based neutron source

Nakai, Kei*; Yamamoto, Yohei*; Yamamoto, Tetsuya*; Yoshida, Fumiyo*; Matsumura, Akira*; Koka, Masashi; Yamada, Naoto; Kitamura, Akane; Sato, Takahiro; Yokoyama, Akihito; et al.

no journal, , 

no abstracts in English

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