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Kitazato, Kohei*; Milliken, R. E.*; Iwata, Takahiro*; Abe, Masanao*; Otake, Makiko*; Matsuura, Shuji*; Takagi, Yasuhiko*; Nakamura, Tomoki*; Hiroi, Takahiro*; Matsuoka, Moe*; et al.
Nature Astronomy (Internet), 5(3), p.246 - 250, 2021/03
Times Cited Count：43 Percentile：96.93(Astronomy & Astrophysics)Here we report observations of Ryugu's subsurface material by the Near-Infrared Spectrometer (NIRS3) on the Hayabusa2 spacecraft. Reflectance spectra of excavated material exhibit a hydroxyl (OH) absorption feature that is slightly stronger and peak-shifted compared with that observed for the surface, indicating that space weathering and/or radiative heating have caused subtle spectral changes in the uppermost surface. However, the strength and shape of the OH feature still suggests that the subsurface material experienced heating above 300 
C, similar to the surface. In contrast, thermophysical modeling indicates that radiative heating does not increase the temperature above 200 C at the estimated excavation depth of 1 m, even if the semimajor axis is reduced to 0.344 au. This supports the hypothesis that primary thermal alteration occurred due to radiogenic and/or impact heating on Ryugu's parent body.
Kitazato, Kohei*; Milliken, R. E.*; Iwata, Takahiro*; Abe, Masanao*; Otake, Makiko*; Matsuura, Shuji*; Arai, Takehiko*; Nakauchi, Yusuke*; Nakamura, Tomoki*; Matsuoka, Moe*; et al.
Science, 364(6437), p.272 - 275, 2019/04
Times Cited Count：259 Percentile：99.73(Multidisciplinary Sciences)The near-Earth asteroid 162173 Ryugu, the target of Hayabusa2 sample return mission, is believed to be a primitive carbonaceous object. The Near Infrared Spectrometer (NIRS3) on Hayabusa2 acquired reflectance spectra of Ryugu's surface to provide direct measurements of the surface composition and geological context for the returned samples. A weak, narrow absorption feature centered at 2.72 micron was detected across the entire observed surface, indicating that hydroxyl (OH)-bearing minerals are ubiquitous there. The intensity of the OH feature and low albedo are similar to thermally- and/or shock-metamorphosed carbonaceous chondrite meteorites. There are few variations in the OH-band position, consistent with Ryugu being a compositionally homogeneous rubble-pile object generated from impact fragments of an undifferentiated aqueously altered parent body.
wild-type and mutant colorectal cancer using 
Cu-labeled cetuximab positron emission tomographyAchmad, A.*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Yamamoto, Shinji*; Tominaga, Hideyuki*; Araki, Takuya*; Ohshima, Yasuhiro; Oriuchi, Noboru*; Endo, Keigo*
Cancer Science, 103(3), p.600 - 605, 2012/03
Times Cited Count：25 Percentile：55.86(Oncology)Uozumi, Yusuke*; Iwamoto, Hiroki*; Koba, Yusuke*; Matsufuji, Naruhiro*; Sanami, Toshiya*; Satoh, Daiki; Shigyo, Nobuhiro*; Takada, Masashi*; Ueyama, Masahiko*; Yoshioka, Masakatsu*; et al.
Progress in Nuclear Science and Technology (Internet), 1, p.114 - 117, 2011/02
It is important to assess and suppress the potential for second cancer induction by secondary neutrons produced in primary heavy-ion fragmentation in patient body. Since it is very difficult to measure high-energy neutron doses in mixed radiation fields, a Monte-Carlo simulation approach has attracted much attention as an alternative for neutron dose estimation. It is notoriously hard to reproduce the spectral cross sections of neutrons from high-energy heavy-ion collisions. We, therefore, have planned experiments to measure energy-angle double-differential cross sections of nuclear reactions.
Cu -labeled trastuzumab PETPaudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.
JAEA-Review 2010-065, JAEA Takasaki Annual Report 2009, P. 108, 2011/01
Cu-labeled trastuzumab PETPaudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.
Cancer Science, 101(4), p.1045 - 1050, 2010/04
Times Cited Count：38 Percentile：66.53(Oncology)Iida, Yasuhiko*; Hanaoka, Hirofumi*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; Yoshioka, Hiroki*; Yamamoto, Shinji*; Paudyal, P.*; Paudyal, B.*; Higuchi, Tetsuya*; et al.
JAEA-Review 2009-041, JAEA Takasaki Annual Report 2008, P. 108, 2009/12
Iida, Yasuhiko*; Hanaoka, Hirofumi*; Paudyal, P.*; Paudyal, B.*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Matsuhashi, Shimpei; Yoshioka, Hiroki*; Higuchi, Tetsuya*; et al.
JAEA-Review 2008-055, JAEA Takasaki Annual Report 2007, P. 114, 2008/11
Br; labeling precursor as an PET imaging agent for a cancer diagnosisIshioka, Noriko; Watanabe, Shigeki; Suto, Hiroyuki*; Suzui, Nobuo; Matsuhashi, Shimpei; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Endo, Keigo*
no journal, ,
no abstracts in English
Iida, Yasuhiko*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Miyakubo, Mitsuyuki*; Paudyal, B.*; Higuchi, Tetsuya*; Oriuchi, Noboru*; Endo, Keigo*; Katabuchi, Tatsuya*; Ishioka, Noriko; et al.
no journal, ,
no abstracts in English
BrIshioka, Noriko; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Suzui, Nobuo; Matsuhashi, Shimpei; Endo, Keigo*
no journal, ,
no abstracts in English
Br PET-radionuclide and Br-labeled antibody for PET imaging of cancer diagnosisIshioka, Noriko; Iida, Yasuhiko*; Watanabe, Shigeki; Yoshioka, Hiroki*; Hanaoka, Hirofumi*; Suzui, Nobuo; Matsuhashi, Shimpei; Endo, Keigo*
no journal, ,
no abstracts in English
Iida, Yasuhiko*; Hanaoka, Hirofumi*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Matsuhashi, Shimpei; Yoshioka, Hiroki*; Endo, Keigo*
no journal, ,
no abstracts in English
Br production and labelling of monoclonal antibody for PET imaging of cancerIshioka, Noriko; Watanabe, Shigeki; Suzui, Nobuo; Matsuhashi, Shimpei; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Endo, Keigo*
no journal, ,
no abstracts in English
Cu labeled monoclonal antibodyPaudyal, P.*; Paudyal, B.*; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Takayanagi, Megumi*; Yoshioka, Hiroki*; Oriuchi, Noboru*; et al.
no journal, ,
Iida, Yasuhiko*; Paudyal, P.*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Hanaoka, Hirofumi*; Zhang, S.*; Hosaka, Masahiro*; Takeuchi, Toshiyuki*; Tobita, Seiji*; Watanabe, Satoshi; et al.
no journal, ,
no abstracts in English
Iida, Yasuhiko*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Takayanagi, Megumi*; Watanabe, Shigeki; Ishioka, Noriko; Watanabe, Satoshi; Matsuhashi, Shimpei; Paudyal, P.*; Higuchi, Tetsuya*; et al.
no journal, ,
Cu labeled trastuzumab in Her2/neu overexpressing non-small cell lung cancer xenograftsPaudyal, P.*; Paudyal, B.*; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Takayanagi, Megumi*; Yoshioka, Hiroki*; Oriuchi, Noboru*; et al.
no journal, ,
Cu -labeled trastuzumab PETPaudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.
no journal, ,
Nobuhara, Fumiyoshi*; Hirao, Yoshihiro*; Matsuda, Norihiro; Sakamoto, Hiroki*; Sakamoto, Yukio*; Iwashita, Mitsushige*; Yoshioka, Kentaro*
no journal, ,
no abstracts in English
Takir, D.*; Kitazato, Kohei*; Milliken, R. E.*; Iwata, Takahiro*; Abe, Masanao*; Otake, Makiko*; Matsuura, Shuji*; Arai, Takehiko*; Nakauchi, Yusuke*; Nakamura, Tomoki*; et al.
no journal, ,
JAXA spacecraft and sample return mission Hayabusa2 has arrived at the near-Earth asteroid 162173 Ryugu, which is classified a primitive carbonaceous object. Here we report recent results of near-infrared spectrometer (NIRS3) on the Hayabusa2 spacecraft. The observations provide direct measurements of the surface composition of Ryugu and context for the returned samples. NIRS3 has detected a weak and narrow absorption feature centered at 2.72 micrometer across entire observed surface. This absorption feature is attributed to the presence of OH-bearing minerals. The NIRS3 observations also revealed that Ryugu is the darkest object to be observed up-close by a visiting spacecraft. The intensity of the OH feature and low albedo are consistent with thermally-and/or shock-metamorphosed, and/or carbon-rich space-weathered primitive and hydrated carbonaceous chondrites.
