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Journal Articles

Knowledge discovery of suppressive effect of disease and increased anti-oxidative function by low-dose radiation using self-organizing map

Kanzaki, Norie; Kataoka, Takahiro*; Kobashi, Yusuke*; Yunoki, Yuto*; Ishida, Tsuyoshi*; Sakoda, Akihiro; Ishimori, Yuu; Yamaoka, Kiyonori*

Radioisotopes, 67(2), p.43 - 57, 2018/02

We previously reported that low-dose radiation induces the anti-oxidative function in many organ systems of mice. This results in the suppression of several kinds of oxidative stress-induced damage. This study was conducted with the objective of revealing the health effects of low-dose radiation obtained from our previous reports and searching for a new treatment based on low-dose radiation, such as radon therapy. We extracted the characteristics of the effects of low dose radiation suppressing diseases and enhancing the anti-oxidative function using fuzzy answer by self-organizing map (SOM) based on mutual knowledge. The relationship between the suppressive effect and increased antioxidative function was shown in our result, and the concentration dependence of the effect against pain was shown on the output map. Although the effect against other organs depending on concentration was unpredictable, our results indicate that low-dose radiation may also be suitable for treatment of liver disease and brain disease.

Oral presentation

Comparative of suppressive effects by low-dose radiation and related-medicine using machine learning

Kanzaki, Norie; Kataoka, Takahiro*; Kobashi, Yusuke*; Ishida, Tsuyoshi*; Yunoki, Yuto*; Sakoda, Akihiro; Ishimori, Yuu; Yamaoka, Kiyonori*

no journal, , 

We have suggested that low-dose radiation increases anti-oxidative function and inhibits various oxidative stress-related diseases. On the other hand, there are some reports about the extraction of some plants which inhibit similar diseases. In this research, we collected and analyzed the reports for comprehensive comparison. For example, we found that the effects of radon 2000 Bq/m$$^{3}$$ inhalation for 24 hours (low-dose irradiation) or taraxeren-3-one (the extraction from diospyros maritima) 20 mg/kg bodyweight administration were similar with the effects of indomethacin 10 mg/kg bodyweight administration regarding carrageenan-induced paw edema. Our results have a limitation of small dataset but are useful for future research about oxidative stress.

Oral presentation

Comparative study on inhibitory effects of radon inhalation and related drugs administration for oxidative stress diseases

Kanzaki, Norie; Kataoka, Takahiro*; Kobashi, Yusuke*; Ishida, Tsuyoshi*; Yunoki, Yuto*; Sakoda, Akihiro; Ishimori, Yuu; Yamaoka, Kiyonori*

no journal, , 

We have reported that radon inhalation inhibits oxidative stress-related diseases. In our previous study, we comprehensively evaluated the results. The datasets were normalized in 0 as the control data and 1 as the disease data. However, the suppressive effects vary depending on the disease type. In the present study, we classified them and analyzed the data of each organ. Therefore, we could compare radon therapy with other treatments in detail.

Oral presentation

Study on the solubility of radon water in sebum components and its temperature dependence

Ishida, Tsuyoshi; Sakoda, Akihiro; Kataoka, Takahiro*; Kanzaki, Norie; Tanaka, Hiroshi; Yunoki, Yuto*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

no journal, , 

We focused on the sebum layer and examined the solubility of radon in the components and its temperature dependence in order to clarify the effect of radon water on skin. As a result, the solubility of radon water by sebum component showed the maximum value for methyl myristate and squalene at each temperature, and the minimum value for triolein. In addition, it could also be suggested that triolein is greatly involved in the solubility of radon in sebum.

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