Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET

Shiina, Takuya*; Watanabe, Ritsuko; Suzuki, Masao*; Yokoya, Akinari

Journal of Radiation Research, 55(Suppl.1), p.i15 - i16, 2014/03

BB2013-0476.pdf:0.21MB

https://doi.org/10.1093/jrr/rrt160

Visualization of cell-cycle modification by ionizing irradiation in single HeLa cells using fluorescent ubiquitination-based cell-cycle indicator

Kaminaga, Kiichi; Sakamoto, Yuka; Kanari, Yukiko; Noguchi, Miho; Yokoya, Akinari

Journal of Radiation Research, 55(Suppl.1), p.i127 - i128, 2014/03

https://doi.org/10.1093/jrr/rrt159

Order effect of repair processes to clustered DNA damage

Shiraishi, Iyo; Suzuki, Masao*; Shikazono, Naoya; Fujii, Kentaro; Yokoya, Akinari

Journal of Radiation Research, 55(Suppl.1), p.i92 - i93, 2014/03

https://doi.org/10.1093/jrr/rrt152

Exploration of the site responsible for the radiation response of the salt chemotaxis learning in using heavy-ion microbeam

Sakashita, Tetsuya; Suzuki, Michiyo; Muto, Yasuko*; Hattori, Yuya; Ikeda, Hiroko; Yokota, Yuichiro; Funayama, Tomoo; Hamada, Nobuyuki*; Fukamoto, Kana*; Kobayashi, Yasuhiko

no journal, , 

An increasing body of data indicates that ionizing radiation causes learning impairments. To understand the effects of ionizing radiation on the nervous system, we have studied the salt chemotaxis learning in . We recently found the modulatory effect of -rays on the salt chemotaxis learning that was manifested as a decrease in chemotaxis. However, we have no direct evidence for the interaction of ionizing radiation with the central neuronal tissue (nerve ring) of the nervous system in . Localized ionizing irradiation is useful to analyze radiation effects at a cellular or tissue level. Thus, to investigate the effects on the nerve ring, we used the heavy-ion microbeam system installed at the Takasaki Ion accelerators for Advanced Radiation Application of JAEA. In this presentation, we will discuss the preliminary results and a future vision of this study.

Systematic measurements of lineal energy distributions of various energetic heavy ion beams using a wall-less tissue equivalent proportional counter

Tsuda, Shuichi; Sato, Tatsuhiko; Watanabe, Ritsuko; Takada, Masashi*

no journal, , 

Deposit energy distribution in a microscopic site is basic information for understanding of biological effects of energetic heavy ion beams. To estimate relative biological effectiveness, RBE, lineal energy, y, is used in simulation models as a physical index because y can treat each energy deposition in a microdosimetric scale by a single event of both incident primary heavy ions and secondary particles. In the present work, using a wall-less tissue equivalent proportional counter, y distributions, yf(y), have been measured for various energetic heavy ions of H, He, C, Si and Fe, and compared with results by simulation codes. The results of yf(y) distributions obtained using a narrow-shape beam and radial dependence of yf(y) distributions will be also shown in the presentation, along with the calculation results by the PHITS code and a track structure simulation code TRACION.