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Pinak, M.; Laaksonen, A.
Molecular Mechanisms for Radiation-Induced Cellular Response and Cancer Development, p.266 - 273, 2003/00
The molecular dynamics (MD) simulations of DNA mutagenic oxidative lesion - 7,8-dihydro-8-oxoguanine (8-oxoG), single and complexed with the repair enzyme - human oxoguanine glycosylase 1 (hOGG1), were performed for 1 nanosecond (ns) in order to determine structural changes at the DNA molecule and to describe a dynamical process of DNA-enzyme complex formation. The broken hydrogen bonds resulting in locally collapsed B-DNA structure were observed at the lesion site. In addition the adenine on the complementary strand (separated from 8-oxoG by 1 base pair) was flipped-out of the DNA double helix. In the case of simulation of DNA and repair enzyme hOGG1, the DNA-enzyme complex was formed after 500 picoseconds of MD that lasted stable until the simulation was terminated at 1 ns.
Ota, Masakazu; Terada, Hiroaki; Koarashi, Jun; Nagai, Haruyasu
no journal, ,
We present the Japan Atomic Energy Agency (JAEA)'s work regarding the development of a land surface model and its applications to transport of radionuclides around nuclear facilities, such as the Rokkasho reprocessing plant of Japan Nuclear Fuel Limited. In particular, we focus on the environmental transfers of
C and
I - the major radionuclides of concern in respect to their potential impacts on radiological doses and long-lasting contamination of the terrestrial environment. JAEA has been developing a land surface model, named SOLVEG-II, that predicts transfer and exchange of water and CO
in an atmosphere-vegetation-soil system. We have introduced dynamics of
C and
I into SOLVEG-II; the developed model is therefore able to calculate the dynamics of
C and
I under realistic conditions with influences from water and CO
cycles in the target land surface ecosystem. Through applying the model to the transfer of
C and
I discharged from the Rokkasho reprocessing plant, key processes affecting contamination of vegetation were identified. In the presentation, some other applications (e.g. transfers of tritium and radiocesium) of the model will also be viewed.
Hashimoto, Hiroki*; Tamakuma, Yuki*; Yamada, Ryohei; Hosoda, Masahiro*; Tokonami, Shinji*
no journal, ,