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Journal Articles

Protective effects of silybin and analogues against X-ray radiation-induced damage

Fu, H. Y.*; Lin, M.; Katsumura, Yosuke*; Yokoya, Akinari; Hata, Kuniki; Muroya, Yusa*; Fujii, Kentaro; Shikazono, Naoya

Acta Biochimica et Biophysica Sinica, 42(7), p.489 - 495, 2010/07

 Times Cited Count:11 Percentile:32.4(Biochemistry & Molecular Biology)

Silybin (SLB) and similar analogues, namely, hesperetin (HESP), naringenin (NAN) and naringin (NAR), are believed to be active constituents of natural flavonoids that have been reported as chemopreventive agents for certain cancers. Moreover, SLB and analogues have been determined to fast repair DNA bases from oxidative damage by pulse radiolysis techniques. The present study was designed to evaluate the protective effects of SLB and analogues on soft X-ray-induced damage to plasmid DNA in vitro. Among the compounds tested, HESP and SLB were the most effective in preventing X-ray-induced formation of DNA single-strand breaks (SSB). A comparison of these results with other experiments showed that the ability of SLB and analogues to inhibit DNA damage in vitro correlated with the ability of the compounds to scavenge free radicals. Our work revealed that natural flavonoids, SLB and analogues may be used as potent protectors against radiation damage.

Journal Articles

Experimental study on $$K$$$$_{alpha}$$ X-ray emission from intense femtosecond laser-solid interactions

Xu, M. H.*; Chen, L.-M.; Li, Y.-T.*; Yuan, X.-H.*; Liu, Y.-Q.*; Nakajima, Kazuhisa; Tajima, Toshiki; Wang, Z.-H.*; Wei, Z.-Y.*; Zhao, W.*; et al.

Acta Physica Sinica, 56(1), p.353 - 358, 2007/01

The characteristics of $$K$$$$_{alpha}$$ X-ray sources generated by p-polarized femtosecond laser-solid interactions are experimentally studied in the relativistic regime. By use of knife-edge image technique and a single-photon-counting X-ray CCD camera, we obtain the source size, the spectrum and the conversion efficiency of the $$K$$$$_{alpha}$$ X-ray sources. The experimental results show that the conversion efficiency of $$K$$$$_{alpha}$$ photons reaches an optimum value 7.08$$times$$10$$^{-6}$$/sr at the laser intensity of 1.6$$times$$10$$^{18}$$W/cm$$^{2}$$, which is different from the Reich's simulation results. We find that about 10% of laser energy is converted into the forward hot electrons at the laser intensity of 1.6$$times$$10$$^{18}$$W/cm$$^{2}$$.

Journal Articles

Vacancy-type defects induced by He-implantation in ZnO studied by a slow positron beam

Chen, Z. Q.*; Kawasuso, Atsuo

Acta Physica Sinica, 55(8), p.4535 - 4540, 2006/08

ZnO single crystals were implanted with with He ions with energies of 20-100keV to a dose of 4E+15 cm$$^{-3}$$. To study, implantation-induced defects, the Doppler broadeing measurements of positron-electron annihilation radiation were performed using a positron beam. As a result, it was found that divacancies and further vacancy clusters were generated due to implantation. It was found that upon annealing at 400 $$^{circ}$$C He atoms start to occupy vacancy clusters. After further annealing at 600 $$^{circ}$$C, vacancy cluster sizes increased. At 800 $$^{circ}$$C, He atoms desorbed from vacancy clusters and vacancy clusters also disappeared.

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