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Journal Articles

Determination of the Compound Biological Effectiveness (CBE) factors based on the ISHIYAMA-IMAHORI deterministic parsing model with the dynamic PET technique

Ishiyama, Shintaro; Imahori, Yoshio*; Itami, Jun*; Koivunoro, H.*

Journal of Cancer Therapy, 6(8), p.759 - 766, 2015/08

https://doi.org/10.4236/jct.2015.68083

From the concentration of 10BPA drug was intravenously injected into the tumor and normal cells of brain tumor patients measured by dynamic PET method, the CBE factor for the BNCT treatment can be calculated by using ISHIYAMA-IMAHORI model.

Journal Articles

Deterministic parsing model of the compound biological effectiveness (CBE) factor for intracellular $$^{10}$$boron distribution in boron neutron capture therapy

Ishiyama, Shintaro

Journal of Cancer Therapy, 5(14), p.1388 - 1398, 2014/12

https://doi.org/10.4236/jct.2014.514140

Deterministic parsing model of Compound Biological Effectiveness (CBE) in BPA-mediated BNCT was proposed for intra-organ $$^{10}$$B distribution. In defining the biological effects of the $$^{10}$$B($$n$$,$$alpha$$)$$^{7}$$Li neutron capture reaction, CBE factor model is expressed; CBE = CBE$$_{0}$$ ($$r_{0}$$ $$<$$ $$r$$ or $$N$$ $$<$$ $$N_{rm th}$$) and CBE = CBE$$_{0}$$ + $$F$$[1-($$N$$/$$N_{rm th}$$)(-2/3)][1-($$N$$/$$N_{rm th}$$)(-1/3)] ($$r_{0}$$ $$>$$ $$r$$ or $$N$$$$>$$$$N_{rm th}$$) Where $$r$$ and $$r_{0}$$ are distance between boron atoms and $$alpha$$ range, $$N$$ and $$N_{rm th}$$ are boron concentration and threshold of $$^{10}$$B concentration in tissues and tumour, CBE$$_{0}$$ and $$F$$ are obtained as 0.5 and 8 for normal tissues and for tumour, respectively. $$N$$ and $$N_{rm th}$$ are evaluated the bio-distribution of $$^{10}$$B in normal tissues and tumour after injection and the CBE factor for normal tissues and tumor approximately within + 0.12 to -0.54% high accuracy.

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