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Lin, M.; 勝村 庸介; 端 邦樹; 室屋 裕佐*; 中川 恵一*
Journal of Photochemistry and Photobiology B; Biology, 89(1), p.36 - 43, 2007/11
被引用回数:28 パーセンタイル:56.37(Biochemistry & Molecular Biology)The reactions between edaravone and various one-electron oxidants such as OH, N, Br
, and SO
radical have been studied by pulse radiolysis techniques. The transient species produced by the reaction of edaravone with OH radical shows an absorption band with
= 320 nm, while the oxidation by N
, Br
, SO
and CCl
OO results in an absorption band with
= 345 nm. Different from the previous reports, the main transient species by the reaction of edaravone with OH radical in the absence of O
is attributed to OH-adducts. At neutral condition (pH 7), the rate constants of edaravone reacting with OH, N
, SO
, CCl
OO, and
are estimated to be 8.5
10
, 5.8
10
, 6
10
, 5.0
10
and 2.4
10
dm
mol
s
, respectively. From the pH dependence on the formation of electron adducts and on the rate constant of edaravone with hydrated electron, the pKa of edaravone is estimated to be 6.9
0.1.