JAEA
  • help
  • PC | SP
  • JP | EN
          
Refine your search：     
Report No.
 - 
Clear All
Search Results: Records 1-6 displayed on this page of 6
  • 1

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Journal Articles

Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for $$alpha$$ radionuclide therapy

Ogawa, Kazuma*; Mizuno, Yoshiaki*; Washiyama, Koshin*; Shiba, Kazuhiro*; Takahashi, Naruto*; Kozaka, Takashi*; Watanabe, Shigeki; Shinohara, Atsushi*; Odani, Akira*

Nuclear Medicine and Biology, 42(11), p.875 - 879, 2015/11

https://doi.org/10.1016/j.nucmedbio.2015.07.001
 Times Cited Count：25 Percentile：71.48(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Preparation and biological evaluation of 3-[$$^{76}$$Br]bromo-$$alpha$$-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Sugo, Yumi; Watanabe, Satoshi; Tominaga, Hideyuki*; Oriuchi, Noboru*; Endo, Keigo*; Ishioka, Noriko

Nuclear Medicine and Biology, 38(6), p.857 - 865, 2011/08

https://doi.org/10.1016/j.nucmedbio.2011.02.001
 Times Cited Count：14 Percentile：46.34(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Chelating ion-exchange methods for the preparation of no-carrier-added $$^{64}$$Cu

Watanabe, Shigeki; Watanabe, Satoshi; Liang, J. X.; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

Nuclear Medicine and Biology, 36(6), p.587 - 590, 2009/09

https://doi.org/10.1016/j.nucmedbio.2009.04.005
 Times Cited Count：7 Percentile：25.25(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Assessment of $$^{186}$$Re chelate-conjugated bisphosphonate for the development of new radiopharmaceuticals for bones

Uehara, Tomoya*; Jin, Z. L.*; Ogawa, Kazuma*; Akizawa, Hiromichi*; Hashimoto, Kazuyuki; Nakayama, Morio*; Arano, Yasushi*

Nuclear Medicine and Biology, 34(1), p.79 - 87, 2007/01

https://doi.org/10.1016/j.nucmedbio.2006.10.001
 Times Cited Count：25 Percentile：58.22(Radiology, Nuclear Medicine & Medical Imaging)

In this study, a key factor affecting the pharmacokinetics of a chelate-conjugated BP was investigated to estimate the validity and the applicability of molecular design. Chemically inert and well-characterized [$$^{186}$$Re]CpTR-Gly was conjugated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate and purified by HPLC to prepare [$$^{186}$$Re]CpTR-Gly-APD. Plasma stability, plasma protein binding, hydroxyapatite (HA) binding and the pharmacokinetics of [$$^{186}$$Re]CpTR-Gly-APD were compared with those of $$^{186}$$Re 1-hydroxyethylidene-1,1-diphosphonate (HEDP). The HPLC-purified [$$^{186}$$Re]CpTR-Gly-APD showed higher plasma stability, higher HA binding, higher bone accumulation and lower plasma protein binding than did $$^{186}$$Re -HEDP. Although $$^{186}$$Re -HEDP possessed HA binding and bone accumulation similar to those of [$$^{186}$$Re]CpTR-Gly-APD, the specific activity of $$^{186}$$Re -labeled BPs was found to play a crucial role in bone accumulation and blood clearance. Thus, the molecular design of chelate-conjugated BP would be useful for the development of bone-seeking radiopharmaceuticals with a variety of radionuclides by selecting chelating molecules that provide high specific activities.

Journal Articles

Rhemium-186-monoaminemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation

Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Otaka, Akira*; Ueda, Masashi*; Uehara, Tomoya*; Magata, Yasuhiro*; Hashimoto, Kazuyuki; Saji, Hideo*

Nuclear Medicine and Biology, 33(4), p.513 - 520, 2006/05

https://doi.org/10.1016/j.nucmedbio.2006.03.006
 Times Cited Count：56 Percentile：80.53(Radiology, Nuclear Medicine & Medical Imaging)

To develop a radiopharmaceutical for the palliation of painful bone metastases based on the concept of bifunctional radiopharmaceuticals, we synthesized a bisphosphonate derivative labeled with rhenium-186 ($$^{186}$$Re) that contains a hydroxyl group at the central carbon of its bisphosphonate structure and attached a stable $$^{186}$$Re-MAMA chelate to the amino group of a 4-amino-butylidene-bisphosphonate derivative, $$^{186}$$Re-MAMA-HBP, and investigated the effect of a hydroxyl group at the central carbon of its bisphosphonate structure on the affinity for hydroxyapatite and biodistribution by conducting a comparative study with $$^{186}$$Re-MAMA-BP. $$^{186}$$Re-MAMA-HBP was prepared by a reaction with $$^{186}$$ReO$$_{4}$$$$^{-}$$ and SnCl$$_{2}$$ in citrate buffer after the deprotection of trityl groups of Tr-MAMA-HBP. After reversed phase HPLC, $$^{186}$$Re-MAMA-HBP had a radiochemical purity of over 95 %. Compared with $$^{186}$$Re-MAMA-BP, $$^{186}$$Re-MAMA-HBP showed a greater affinity for hydroxyapatite beads in vitro and accumulated a significantly higher level in the femur in vivo. Thus, the introduction of a hydroxyl group into $$^{186}$$Re complex-conjugated bisphosphonates would be effective in enhancing accumulation in bone. These findings provide useful information on the design of bone-seeking therapeutic radiopharmaceuticals.

Journal Articles

In vivo recognition of Cyclopentadienyltricarbonylrhenium (CpTR) derivatives

Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Miyamoto, Shigehiko*; Motoishi, Shoji; Hashimoto, Kazuyuki; Oku, Naoto*; Nakayama, Morio*; Arano, Yasushi*

Nuclear Medicine and Biology, 30(3), p.327 - 334, 2003/04

https://doi.org/10.1016/S0969-8051(02)00437-7
 Times Cited Count：20 Percentile：49.60(Radiology, Nuclear Medicine & Medical Imaging)

no abstracts in English

6 (Records 1-6 displayed on this page)
  • 1