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Takai, Toshihide; Furukawa, Tomohiro; Watanabe, Shigeki*; Ishioka, Noriko*
Mechanical Engineering Journal (Internet), 9(4), p.21-00397_1 - 21-00397_11, 2022/08
For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, the National Institute for Quantum and Radiological Science and Technology has proposed the innovative "Liquid Bismuth Target System." The target window in this system must be made from a material that resists the highly corrosive liquid bismuth environment. To meet this requirement, a promising target window material was selected in corrosion experiments performed in stagnant liquid bismuth. Based on knowledge of corrosion in liquid lead-bismuth eutectic gained during the development of fast reactors and accelerator-driven subcritical systems, experiments were carried out under saturated dissolved oxygen and low oxygen conditions, and the corrosion behaviors of the specimens were evaluated. The FeCrAl-alloy exhibited the most excellent corrosion resistance, followed by FeCrMo-alloy. Both materials are suitable candidates for the target window.
Hashimoto, Kazuyuki; Wan, K. W. H. B. B.*; Matsuoka, Hiromitsu
Journal of Nuclear and Radiochemical Sciences, 6(3), p.193 - 196, 2005/12
The radioisotopes of rhenium (Re and
Re) are attractive radionuclides for radiotherapy because of their energetic beta particles and gamma rays suitable for imaging. Mercaptoacetyltriglycine, MAG3 (N
S ligand), is a useful bifunctional ligand in labeling monoclonal antibodies with metallic radionuclides. In this study, the labeling of MAG3 with carrier-free
Re from a
W/
Re generator was investigated in detail. The
Re-MAG3 complex was synthesized by the direct labeling method and by the indirect labeling method using a transfer ligand (citric acid or gluconic acid). The dependence of the labeling yield upon the reaction conditions such as the concentrations of tin(II) chloride dihydrate as a reducing agent, S-benzoyl MAG3 and the transfer ligand, pH, temperature, reaction time and the addition of a carrier was examined. The labeling yield of
Re-MAG3 synthesized by the all method was over 90% under the optimum conditions.
Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Ono, Masahiro*; Hanaoka, Hirofumi*; Ishino, Seigo*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*
Bioconjugate Chemistry, 16(4), p.751 - 757, 2005/07
Times Cited Count:62 Percentile:87.15(Biochemical Research Methods)Rhenium-186-1-hydroxyethylidene-1,1-diphosphonate (Re-HEDP) has been used for the palliation of metastatic bone pain. Delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of
Re-HEDP in vivo. In this study, on the basis of the concept of bifunctional radiopharmaceuticals, we designed a stable
Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate (
Re-MAG3-HBP). After purification by HPLC,
Re-MAG3-HBP was synthesized with a radiochemical purity of over 95%. In biodistribution experiments, the radioactivity level of
Re-MAG3-HBP in bone was significantly higher than that of
Re-HEDP. Blood clearance of
Re-MAG3-HBP was faster than that of
Re-HEDP. In addition, the gastric accumulation of
Re-MAG3-HBP radioactivity was lower than that of
Re-HEDP. In conclusion,
Re-MAG3-HBP is expected to be a useful radiopharmaceutical for the palliation of metastatic bone pain.
Horiuchi, Kazuko*; Konno, Aya*; Ueda, Mayumi*; Fukuda, Yoko*; Nishio, Saori*; Hashimoto, Kazuyuki; Saji, Hideo*
European Journal of Nuclear Medicine and Molecular Imaging, 31(3), p.388 - 398, 2004/03
Times Cited Count:21 Percentile:50.12(Radiology, Nuclear Medicine & Medical Imaging)no abstracts in English
Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Miyamoto, Shigehiko*; Motoishi, Shoji; Hashimoto, Kazuyuki; Oku, Naoto*; Nakayama, Morio*; Arano, Yasushi*
Nuclear Medicine and Biology, 30(3), p.327 - 334, 2003/04
Times Cited Count:20 Percentile:50.03(Radiology, Nuclear Medicine & Medical Imaging)no abstracts in English
Isotope News, 0(508), p.12 - 15, 1996/09
no abstracts in English
Suematsu, Hisayuki*; Ngo, M. C.*; Quach, N. M.*; Fujita, Yoshitaka; Do, T. M. D.*; Nakayama, Tadachika*; Suzuki, Tatsuya*; Nguyen, V. T.*; Niihara, Koichi*
no journal, ,
Radiopharmacies have been used in various medical diagnoses/therapies and their market has been growing by ten times in fifteen years. In particular, Tc has been widely used in gamma ray diagnoses.
Mo, the raw material for
Tc, is currently produced as a fission product by irradiating highly enriched uranium in nuclear reactors. Efforts are being made worldwide to reduce the use of uranium from the perspective of nuclear non-proliferation. A
Mo(n,
)
Mo reaction in low enriched uranium reactors can be an alternative method. In this research, we revealed that
-MoO
, a low-temperature phase of MoO
, as a neutron irradiation target promotes the diffusion of
Mo from the target to water due to the hot atom effect. Utilizing this phenomenon can contribute to the stable supply of
Mo and
Tc. The first nuclear reaction in/water dispersion experiments using an
-MoO
powder target was carried out in Dalat Nuclear Reactor, Vietnam Atomic Energy Institute to show the hot atom effect. Then, the water recovery efficiency was dramatically improved using a novel
-MoO
whisker target by Vietnamese students and staffs. Their contributions to this research will be explained in the presentation.
Takai, Toshihide; Furukawa, Tomohiro; Watanabe, Shigeki*; Ishioka, Noriko*
no journal, ,
For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, the National Institute for Quantum and Radiological Science and Technology has proposed the innovative "Liquid Bismuth Target System." The target window in this system must be made from a material that resists the highly corrosive liquid bismuth environment. To meet this requirement, a promising target window material was selected in corrosion experiments performed in stagnant liquid bismuth. Based on knowledge of corrosion in liquid lead-bismuth eutectic gained during the development of fast reactors and accelerator-driven subcritical systems, experiments were carried out under saturated dissolved oxygen and low oxygen conditions, and the corrosion behaviors of the specimens were evaluated. The FeCrAl-alloy exhibited the most excellent corrosion resistance, followed by FeCrMo-alloy. Both materials are suitable candidates for the target window.