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W/Re generatorsMatsuoka, Hiromitsu; Hashimoto, Kazuyuki; Hishinuma, Yukio*; Ishikawa, Koji*; Terunuma, Hitoshi*; Tatenuma, Katsuyoshi*; Uchida, Shoji*
Journal of Nuclear and Radiochemical Sciences, 6(3), p.189 - 191, 2005/12
Applicability of Mo adsorbent PZC(Poly Zirconium Compound) for W/Re generator was investigated. Long term stability of adsorption of W to the PZC column, elution of Re from PZC column, desorption of 
from PZC column, and labeling of Hydroxyethylidene Diphosphonic Acid(HEDP) and Mercaptoacetyltriglycine(MAG3) with Re eluted from PZC column were tested. The PZC generator gave reproducible Re elution yields with low W parent breakthrough for a long period of time(about 5 months), that is the W/Re generator using PZC has a potential for practical use.
ReHashimoto, Kazuyuki; Wan, K. W. H. B. B.*; Matsuoka, Hiromitsu
Journal of Nuclear and Radiochemical Sciences, 6(3), p.193 - 196, 2005/12
The radioisotopes of rhenium (
Re and Re) are attractive radionuclides for radiotherapy because of their energetic beta particles and gamma rays suitable for imaging. Mercaptoacetyltriglycine, MAG3 (N
S ligand), is a useful bifunctional ligand in labeling monoclonal antibodies with metallic radionuclides. In this study, the labeling of MAG3 with carrier-free Re from a W/Re generator was investigated in detail. The Re-MAG3 complex was synthesized by the direct labeling method and by the indirect labeling method using a transfer ligand (citric acid or gluconic acid). The dependence of the labeling yield upon the reaction conditions such as the concentrations of tin(II) chloride dihydrate as a reducing agent, S-benzoyl MAG3 and the transfer ligand, pH, temperature, reaction time and the addition of a carrier was examined. The labeling yield of Re-MAG3 synthesized by the all method was over 90% under the optimum conditions.
Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Ono, Masahiro*; Hanaoka, Hirofumi*; Ishino, Seigo*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*
Bioconjugate Chemistry, 16(4), p.751 - 757, 2005/07
Times Cited Count：64 Percentile：87.36(Biochemical Research Methods)Rhenium-186-1-hydroxyethylidene-1,1-diphosphonate (Re-HEDP) has been used for the palliation of metastatic bone pain. Delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of Re-HEDP in vivo. In this study, on the basis of the concept of bifunctional radiopharmaceuticals, we designed a stable Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate (Re-MAG3-HBP). After purification by HPLC, Re-MAG3-HBP was synthesized with a radiochemical purity of over 95%. In biodistribution experiments, the radioactivity level of Re-MAG3-HBP in bone was significantly higher than that of Re-HEDP. Blood clearance of Re-MAG3-HBP was faster than that of Re-HEDP. In addition, the gastric accumulation of Re-MAG3-HBP radioactivity was lower than that of Re-HEDP. In conclusion, Re-MAG3-HBP is expected to be a useful radiopharmaceutical for the palliation of metastatic bone pain.
Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*
Journal of Labelled Compounds and Radiopharmaceuticals, 47(11), p.753 - 761, 2004/11
Times Cited Count：31 Percentile：64.04(Biochemical Research Methods)no abstracts in English
Re-EDTMP complexes by HPLC and ultrafiltrationHashimoto, Kazuyuki; Matsuoka, Hiromitsu
Radiochimica Acta, 92(4-6), p.285 - 290, 2004/07
Times Cited Count：1 Percentile：9.73(Chemistry, Inorganic & Nuclear)no abstracts in English
Lu
and preparation of Lu-EDTMPChen, D.*; Hashimoto, Kazuyuki
Journal of Nuclear and Radiochemistry, 26(2), p.84 - 87, 2004/05
no abstracts in English
Re and Re, synthesis of labeled compounds and their biodistributionsConsultative Committee of Research on Radioisotopes
JAERI-Research 2004-001, 117 Pages, 2004/02
JAERI-Research-2004-001.pdf:5.26MB
no abstracts in English
Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Miyamoto, Shigehiko*; Motoishi, Shoji; Hashimoto, Kazuyuki; Oku, Naoto*; Nakayama, Morio*; Arano, Yasushi*
Nuclear Medicine and Biology, 30(3), p.327 - 334, 2003/04
Times Cited Count：20 Percentile：49.32(Radiology, Nuclear Medicine & Medical Imaging)no abstracts in English
Re biomolecules via EHDPFerro-Flores, G.*; Garcia-Salinas, L.*; Paredes-Gutierrez, L.*; Hashimoto, Kazuyuki; Melendes-Alafort, L.*; Murphy, C. A.*
IAEA-TECDOC-1228, p.99 - 103, 2001/06
no abstracts in English
Matsuhashi, Shimpei; Uchida, Hiroshi*; Kume, Tamikazu
Radioisotopes, 49(11), p.38 - 50, 2000/11
no abstracts in English
Matsuhashi, Shimpei; Kume, Tamikazu
Hoshasen Kagaku, (70), p.20 - 25, 2000/09
no abstracts in English
Ogawa, Kazuma*; Ono, Masahiro*; Fujioka, Yasushi*; Saji, Hideo*; Mukai, Takahiro*; Konishi, Junji*; Uehara, Tomoya*; Arano, Yasushi*; Onoma, Katsuyuki
Kaku Igaku, 37(5), P. 577, 2000/09
no abstracts in English
Sekiguchi, Hiromi*; Sekiguchi, Tetsuhiro; Imamura, Motoyasu*; Matsubayashi, Nobuyuki*; Shimada, Hiromichi*; Baba, Yuji
Photon Factory Activity Report 1998, Part B, P. 37, 1999/11
no abstracts in English
-emitting radionuclides; For bone pain palliationHashimoto, Kazuyuki
Radioisotopes, 48(7), p.505 - 506, 1999/07
no abstracts in English
Re, and a study of their stabilityHashimoto, Kazuyuki
Applied Radiation and Isotopes, 51(3), p.307 - 313, 1999/00
Times Cited Count：12 Percentile：65.45(Chemistry, Inorganic & Nuclear)no abstracts in English
Ishioka, Noriko; Matsuoka, Hiromitsu; Watanabe, Satoshi; Osa, Akihiko; Koizumi, Mitsuo; Matsuhashi, Shimpei; Kume, Tamikazu; Sekine, Toshiaki; Uchida, Hiroshi*; Tsuji, Atsunori*; et al.
Journal of Radioanalytical and Nuclear Chemistry, 239(2), p.417 - 421, 1999/00
Times Cited Count：30 Percentile：87.42(Chemistry, Analytical)no abstracts in English
Re-DMSA and its biodistributions in mice; ; ; ; ; Hashimoto, Kazuyuki;
Journal of Radioanalytical and Nuclear Chemistry, 239(2), p.385 - 389, 1999/00
Times Cited Count：2 Percentile：20.91(Chemistry, Analytical)no abstracts in English
Re and Re, synthesis of labeled compounds and their biodistributionsJAERI-Research 98-015, 197 Pages, 1998/03
JAERI-Research-98-015.pdf:7.65MB
no abstracts in English
Sakamoto, Fuminori; ; ; ; X.S.Tan*; Suzuki, Eiji*; ; Fujii, Yuki*
Chemistry Letters, (11), p.1127 - 1128, 1998/00
no abstracts in English
Ishioka, Noriko
Hoshasen To Sangyo, (80), p.11 - 15, 1998/00
no abstracts in English
