Refine your search:     
Report No.
 - 
Search Results: Records 1-12 displayed on this page of 12
  • 1

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Journal Articles

Study of charged particle activation analysis, 2; Determination of boron concentration in human blood samples

Ikebe, Yurie*; Oshima, Masumi*; Bamba, Shigeru*; Asai, Masato; Tsukada, Kazuaki; Sato, Tetsuya; Toyoshima, Atsushi*; Bi, C.*; Seto, Hirofumi*; Amano, Hikaru*; et al.

Applied Radiation and Isotopes, 164, p.109106_1 - 109106_7, 2020/10

 Times Cited Count:2 Percentile:24.76(Chemistry, Inorganic & Nuclear)

Boron Neutron Capture Therapy (BNCT) is a radiotherapy for the treatment of intractable cancer. In BNCT precise determination of $$^{10}$$B concentration in whole blood sample before neutron irradiation is crucial for control of the neutron irradiation time and the neutron dosimetry. We have applied the Charged Particle Activation Analysis (CPAA) to non-destructive and accurate determination of $$^{10}$$B concentration in whole blood sample. The experiment was performed at JAEA Tandem Accelerator using an 8 MeV proton beam. The 478 keV $$gamma$$ ray of $$^{7}$$Be produced in the $$^{10}$$B(p,$$alpha$$)$$^{7}$$Be reaction was used to quantify the $$^{10}$$B, and $$gamma$$ rays of $$^{56}$$Co originating from the reaction with Fe in blood was used to normalize the $$gamma$$-ray intensity. The results demonstrated that the present CPAA method can be applied to the determination of the $$^{10}$$B concentration in the blood sample.

JAEA Reports

Estimation methods of blood boron concentration and error evaluation during boron neutron capture therapy for malignant brain tumor

Shibata, Yasushi*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Yamamoto, Tetsuya*; Hori, Naohiko; Kishi, Toshiaki; Kumada, Hiroaki; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, Kei*; et al.

JAERI-Research 2005-009, 41 Pages, 2005/03

JAERI-Research-2005-009.pdf:1.99MB

The measurement of neutron flux and boron concentration in the blood during medical irradiation is indispensable in order to evaluate the radiation in boron neutron capture therapy. It is, however, difficult to measure the blood boron concentration during neutron irradiation because access to the patient is limited. Therefore we prospectively investigated the predictability of blood boron concentrations using the data obtained at the first craniotomy after infusion of a low dosage of BSH. When the test could not be carried out, the blood boron concentration during irradiation was also predicted by using the 2-compartment model. If the final boron concentration after the end of the infusion is within 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%. If the final boron concentration at 6 or 9 hours after the end of infusion is out of 95% confidence interval of the prediction, proportional adjustment will reduce error and expected error after adjustment to around 12%.

Journal Articles

Flow injection extraction chromatography with ICP-MS for thorium and uranium determination in human body fluids

Tolmachyov, S.; Kuwabara, Jun*; Noguchi, Hiroshi

Journal of Radioanalytical and Nuclear Chemistry, 261(1), p.125 - 131, 2004/07

 Times Cited Count:23 Percentile:80.3(Chemistry, Analytical)

A method based on flow injection extraction chromatography coupled with on-line ICP-MS (FI-EC-ICPMS) for simultaneous thorium and uranium determination in human body fluids (urine and blood) has been developed and validated. By using extraction chromatography, the limits of detection for $$^{232}$$Th, $$^{235}$$U and $$^{238}$$U were achieved 0.06 ng l$$^{-1}$$, 0.0014 ng l$$^{-1}$$ and 0.05 ng l$$^{-1}$$, respectively. The FI-EC-ICPMS method accuracy was 102.4% and 101.5% with overall precision (RSDmax at 95% CI) of 5.3% and 4.9% for $$^{232}$$Th and $$^{238}$$U, respectively. The $$^{235}$$U/$$^{238}$$U atom ratio is measured with 1.8% precision. The technique was employed for simultaneous thorium and uranium analyses in human urine and blood samples after microwave digestion.

Journal Articles

The Prediction of Boron concentrations in blood for patients of boron neutron capture therapy, 2

Shibata, Yasushi*; Matsumura, Akira*; Yamamoto, Tetsuya*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, Kei*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; et al.

Research and Development in Neutron Capture Therapy, p.1055 - 1060, 2002/09

We prospectively investigated the predictability of blood boron concentrations using the data obtained at the first craniotomy after infusion of a low dose of sodium undecahydroclosododecaborate (BSH). Nine patients with malignant glial tumors underwent Boron neutron capture therapy (BNCT) at the Japan Atomic Energy Research Institute (JAERI) between 1995 and 2001. In 7 patients, 1g of BSH was infused before the first tumor removal and boron concentrations were determined using prompt gamma ray analysis (PGA). Then, 12 hours before BNCT, patients were infused at a dose of 100mg/kg BSH, and the boron concentrations were determined again. The boron biodistribution data showed a biexponential pharmacokinetic profile. If the final boron concentration at 6 or 9 hours after the end of the infusion is within the 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%.

JAEA Reports

Measurement of Boron-10 Concentration in the blood sample for BNCT by prompt $$gamma$$-ray analysis of JRR-4

Yamamoto, Kazuyoshi; Kishi, Toshiaki; Hori, Naohiko; Kumada, Hiroaki; Torii, Yoshiya; Horiguchi, Yoji

JAERI-Tech 2001-016, 34 Pages, 2001/03

JAERI-Tech-2001-016.pdf:1.56MB

no abstracts in English

Journal Articles

Prediction of boron concentration in blood from low dose infusion for the patients of BNCT at JAERI

Shibata, Yasushi*; Matsumura, Akira*; Yamamoto, Tetsuya*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, K.*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.145 - 146, 2000/10

no abstracts in English

Journal Articles

Blood volume measurement of newborn using stable isotope $$^{5}$$$$^{0}$$Cr

; ; Motoki, Ryozo; Yamamoto, Takeo; Nishida, Hiroshi*; Shin, Sumio*; Sato, Kiichi*; *

Radioisotopes, 34(3), p.144 - 150, 1985/00

no abstracts in English

Journal Articles

Blood volume measurements in newborn infants using stable isotope $$^{5}$$$$^{0}$$Cr

Shin, Sumio*; ; *; Nishida, Hiroshi*; ; ; Motoki, Ryozo

Igaku No Ayumi, 130(6-7), p.437 - 439, 1984/00

no abstracts in English

JAEA Reports

Analysis of PKL Test K9 by THYDE-P Code; CSNI ISP No.10 and THYDE-P Sample Calculation Run 70

; ; Asahi, Yoshiro

JAERI-M 82-115, 63 Pages, 1982/09

JAERI-M-82-115.pdf:1.57MB

no abstracts in English

Journal Articles

A method for determination of plutonium in blood by anion exchange

Journal of Nuclear Science and Technology, 6(1), p.12 - 19, 1969/00

no abstracts in English

Journal Articles

Retention, excretion and blood concentration of $$^{1}$$$$^{3}$$$$^{7}$$Cs by rat as influenced by starvation

; ; ;

Journal of Radiation Research, 9(3-4), p.129 - 134, 1968/00

no abstracts in English

Journal Articles

On the blood count by EEL blood cell counter

Rinsho Byori, 9(7), p.453 - 457, 1961/00

no abstracts in English

12 (Records 1-12 displayed on this page)
  • 1