Improved extraction efficiency of radioactive copper produced via accelerator neutrons method through phosphate buffer-enhanced column pre-treatment

Mikhail, M. A. G.*; Kin, Tadahiro*; Eto, Taisei*; Tsukada, Kazuaki

Scientific Reports (Internet), 14, p.27132_1 - 27132_10, 2024/11

https://doi.org/10.1038/s41598-024-76660-y

We have studied a straightforward and robust single-step cation exchange separation method to isolate medical copper radioisotopes Cu and Cu produced in the Zn(n, x) reaction with an accelerator neutrons technique. This study revealed the key role of a phosphate buffer pre-treatment of the cation exchange column in the separation process. It was found that incorporating the phosphate buffer into the column pre-treatment markedly enhances the retention of copper isotopes within the column throughout the separation procedure. This approach yields a high-purity radioactive copper sample with a high extraction efficiency of 94.4% of the initially produced copper, all within a relatively short experimental time frame of approximately 5 h for 100 g of starting material.