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Search Results: Records 1-20 displayed on this page of 27

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Journal Articles

Role of DNA repair and effect of herbal extract on LOH induced by ion beam radiations in ${it Saccharomyces cerevisiae}$

Nunoshiba, Tatsuo*; Yamauchi, Ayako*; Iwata, Rika*; Sato, Katsuya; Ono, Yutaka; Narumi, Issey*

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 124, 2015/03

https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2014-050.pdf#page=156

Journal Articles

Radiation response mechanisms of the extremely radioresistant bacterium ${it Deinococcus radiodurans}$

Kobayashi, Yasuhiko; Narumi, Issei; Sato, Katsuya; Funayama, Tomoo; Kikuchi, Masahiro; Kitayama, Shigeru; Watanabe, Hiroshi*

Uchu Seibutsu Kagaku, 18(3), p.134 - 135, 2004/11

no abstracts in English

Journal Articles

Light dependency of resistance to ionizing radiation in ${it Euglena gracilis}$

Hayashi, Hirotaka; Narumi, Issei; Wada, Seiichi; Kikuchi, Masahiro; Furuta, Masakazu*; Uehara, Kaku*; Watanabe, Hiroshi*

Journal of Plant Physiology, 161(10), p.1101 - 1106, 2004/10

https://doi.org/10.1016/j.jplph.2004.04.005
 Times Cited Count：10 Percentile：23.05(Plant Sciences)

The resistance of ${it Euglena gracilis}$ strains Z (wild type) and SM-ZK (chloroplast-deficient mutant) to ionizing radiation was investigated. The colony forming ability of ${it E. gracilis}$ strain Z was higher than that of strain SM-ZK after $$gamma$$-irradiation. For both strains, the resistance of light-grown cells was higher than that of dark-grown cells, suggesting that the light conditions during the culture contribute to the radiation resistance of ${it E. gracilis}$. The comet assay showed that the ability of rejoining DNA double-strand breaks (dsb) was much higher in the light-grown cells. These results suggest that ${it E. gracilis}$ possesses a light-induced repair system to cope with DNA dsb.

Journal Articles

The Structure of ${it D. radiodurans}$

Battista, J. R.*; Cox, M. M.*; Daly, M. J.*; Narumi, Issei; Radman, M.*; Sommer, S.*

Science, 302(24), p.567 - 568, 2003/10

no abstracts in English

Journal Articles

The Radiation resistant bacterium ${it Deinococcus radiodurans}$

Narumi, Issei

Hoshasen To Chikyu Kankyo; Seitaikei Eno Eikyo O Kangaeru, p.113 - 122, 2003/09

no abstracts in English

Journal Articles

Radiation resistance mechanism of the radioresistant bacterium

Narumi, Issei

Iden, 57(5), p.57 - 62, 2003/09

https://ci.nii.ac.jp/naid/80016099849

no abstracts in English

Journal Articles

Unlocking radiation resistance mechanisms; Still a long way to go

Narumi, Issei

Trends in Microbiology, 11(9), p.422 - 425, 2003/09

https://doi.org/10.1016/S0966-842X(03)00204-X
 Times Cited Count：51 Percentile：89.95(Biochemistry & Molecular Biology)

no abstracts in English

Journal Articles

PprI: A General switch responsible for extreme radioresistance of ${it Deinococcus radiodurans}$

Hua, Y.*; Narumi, Issei; Gao, G.*; Tian, B.*; Sato, Katsuya; Kitayama, Shigeru; Shen, B.*

Biochemical and Biophysical Research Communications, 306(2), p.354 - 360, 2003/06

https://doi.org/10.1016/S0006-291X(03)00965-3
 Times Cited Count：152 Percentile：95.78(Biochemistry & Molecular Biology)

We have identified a unique deinococcal gene, ${it pprI}$, as a general switch for downstream DNA repair and protection pathways, from a natural mutant, in which ${it pprI}$ is disrupted by a transposon. Complete functional disruption of the gene in wild-type leads to dramatic sensitivity to ionizing radiation. Radioresistance of the disruptant could be fully restored by complementation with ${it pprI}$. In response to radiation stress, PprI can significantly and specifically induce the gene expression of ${it recA}$ and ${it pprA}$ and enhance the enzyme activities of catalases. These results strongly suggest that PprI plays a crucial role in regulating multiple DNA repair and protection pathways in response to radiation stress.

Journal Articles

Seeking birthplace of radioresistant bacteria

Narumi, Issei

Science & Technology Journal, 12(5), p.50 - 51, 2003/05

no abstracts in English

Journal Articles

Cloning of structural gene of ${it Deinococcus radiodurans}$ UV-endonuclease $$beta$$

Kitayama, Shigeru; Narumi, Issei; Funayama, Tomoo; Watanabe, Hiroshi

Bioscience Biotechnology and Biochemistry, 67(3), p.613 - 616, 2003/03

https://doi.org/10.1271/bbb.67.613
 Times Cited Count：3 Percentile：13.16(Biochemistry & Molecular Biology)

no abstracts in English

Journal Articles

Sterilization effects of ionizing radiation

Watanabe, Hiroshi

Bokin Bobai-Shi, 30(10), p.683 - 690, 2002/10

http://ci.nii.ac.jp/naid/10011297257

no abstracts in English

Journal Articles

Posttranslational modification of the ${it umuD}$-encoded subunit of ${it Escherichia coli}$ DNA polymerase V regulates its interactions with the $$beta$$ processivity clamp

Sutton, M. D.*; Narumi, Issei; Walker, G. C.*

Proceedings of the National Academy of Sciences of the United States of America, 99(8), p.5307 - 5312, 2002/04

https://doi.org/10.1073/pnas.082322099
 Times Cited Count：37 Percentile：51.64(Multidisciplinary Sciences)

The ${it Escherichia coli umuDC}$ gene products (PolV) participate in both a DNA damage checkpoint control and translesion DNA synthesis. Interactions of the two ${it umuD}$ gene products, UmuD and UmuD' proteins, with components of the replicative DNA polymerase (PolIII), are important for determining which biological role the ${it umuDC}$ gene products will play. We have shown that UmuD possesses a higher affinity for PolIII $$beta$$ processivity clamp than does UmuD' because of the N-terminal arm of UmuD, much of which is missing in UmuD'. Futhermore, we identified specific amino acid residues of UmuD that crosslink to $$beta$$ with a crosslinker, ${it p}$-azidoiodoacetanilide, defining the domain important for the interaction.

Journal Articles

Recognition of DNA damage and induction of repair proteins in ${it Deinococcus radiodurans}$

Sato, Katsuya; Kikuchi, Masahiro; Narumi, Issei

JAERI-Conf 2002-005, p.172 - 184, 2002/03

https://jopss.jaea.go.jp/pdfdata/JAERI-Conf-2002-005.pdf

${it Deinococcus radiodurans possesses}$ a DNA damage response mechanism. However, the damage response is poorly understood in ${it D. radiodurans}$. By investigating the function of deinococcal proteins, we found that, unlike in ${it E. coli}$, LexA is not involved in the regulation of RecA in ${it D. radiodurans}$. This, in turn, led us to speculate that ${it D. radiodurans}$ has an alternative DNA damage response mechanism with which to control ${it recA}$ expression. Recently, we discovered that a novel protein regulates the expression of ${it recA}$ gene. The novel regulatory protein (designated as PprI) also control the induction of ${it pprA}$ gene following $$gamma$$ irradiation. Thus, ${it D. radiodurans}$ possesses unique mechanisms of DNA damage recognition and repair gene induction.

Journal Articles

The LexA protein from ${it Deinococcus radiodurans}$ is not involved in RecA induction following $$gamma$$ irradiation

Narumi, Issei; Sato, Katsuya; Kikuchi, Masahiro; Funayama, Tomoo; Yanagisawa, Tadashi*; Kobayashi, Yasuhiko; Watanabe, Hiroshi; Yamamoto, Kazuo

Journal of Bacteriology, 183(23), p.6951 - 6956, 2001/12

https://doi.org/10.1128/JB.183.23.6951-6956.2001
 Times Cited Count：91 Percentile：84.2(Microbiology)

The involvement of LexA in induction of RecA was investigated in ${it Deinococcus radiodurans}$. As in the wild-type strain, an increase in RecA protein synthesis following $$gamma$$ irradiation was detected in a ${it lexA}$ disruptant, indicating that LexA is not involved in the induction of RecA in ${it D. radiodurans}$.

Journal Articles

Mutation in recR gene of Deinococcus radiodurans and possible in volvement of its product in the repair of DNA interstrand cross-links

Kitayama, Shigeru*; Narumi, Issei; Kikuchi, Masahiro; Watanabe, Hiroshi

Mutation Research; DNA Repair, 461(3), p.179 - 187, 2000/11

no abstracts in English

Journal Articles

Effect of the space environment on the induction of DNA-repair related proteins and recovery from radiation damage

Kobayashi, Yasuhiko; Watanabe, Hiroshi; Kikuchi, Masahiro; Narumi, Issei

Advances in Space Research, 25(10), p.2103 - 2106, 2000/00

https://doi.org/10.1016/S0273-1177(99)01061-3
 Times Cited Count：10 Percentile：80.36(Engineering, Aerospace)

no abstracts in English

Journal Articles

Biological effects of ion beams

Kobayashi, Yasuhiko

Hoshasen Kagaku, (67), p.35 - 39, 1999/03

no abstracts in English

Journal Articles

The Mechanism of radiation hyper-resistance of Deinococcus radiodurans

Narumi, Issei; Kikuchi, Masahiro; Funayama, Tomoo; Sato, Katsuya

Hoshasen Seibutsu Kenkyu, 34(4), p.401 - 418, 1999/00

http://ci.nii.ac.jp/naid/40004413723

no abstracts in English

Journal Articles

Identification and disruption analysis of recN gene in the extreamly radioresistant bacterium Deinococcus radiodurans

Funayama, Tomoo; Narumi, Issei; Kikuchi, Masahiro; Kitayama, Shigeru*; Watanabe, Hiroshi; Yamamoto, Kazuo

Mutation Research; DNA Repair, 435, p.151 - 161, 1999/00

no abstracts in English

Journal Articles

Molecular analysis of the Deinococcus radiodurans recA locus and identification of a mutation site in a DNA repair-deficient mutant, rec30

Narumi, Issei; Sato, Katsuya; Kikuchi, Masahiro; Funayama, Tomoo; Kitayama, Shigeru; Yanagisawa, Tadashi*; Watanabe, Hiroshi; Yamamoto, Kazuo

Mutation Research; DNA Repair, 435(3), p.233 - 243, 1999/00

no abstracts in English

27 (Records 1-20 displayed on this page)