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JAEA Reports

Estimation methods of blood boron concentration and error evaluation during boron neutron capture therapy for malignant brain tumor

Shibata, Yasushi*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Yamamoto, Tetsuya*; Hori, Naohiko; Kishi, Toshiaki; Kumada, Hiroaki; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, Kei*; et al.

JAERI-Research 2005-009, 41 Pages, 2005/03

JAERI-Research-2005-009.pdf:1.99MB

The measurement of neutron flux and boron concentration in the blood during medical irradiation is indispensable in order to evaluate the radiation in boron neutron capture therapy. It is, however, difficult to measure the blood boron concentration during neutron irradiation because access to the patient is limited. Therefore we prospectively investigated the predictability of blood boron concentrations using the data obtained at the first craniotomy after infusion of a low dosage of BSH. When the test could not be carried out, the blood boron concentration during irradiation was also predicted by using the 2-compartment model. If the final boron concentration after the end of the infusion is within 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%. If the final boron concentration at 6 or 9 hours after the end of infusion is out of 95% confidence interval of the prediction, proportional adjustment will reduce error and expected error after adjustment to around 12%.

Journal Articles

Development of a code MOGRA for predicting the migration of ground additions and its application to various land utilization areas

Amano, Hikaru; Takahashi, Tomoyuki*; Uchida, Shigeo*; Matsuoka, Shungo*; Ikeda, Hiroshi*; Hayashi, Hiroko*; Kurosawa, Naohiro*

Journal of Nuclear Science and Technology, 40(11), p.975 - 979, 2003/11

 Times Cited Count:2 Percentile:19.06(Nuclear Science & Technology)

MOGRA is a migration prediction code for toxic ground additions including radioactive materials in a terrestrial environment. MOGRA consists of computational codes that are applicable to various evaluation target systems, and can be used on personal computers. The computational code has the dynamic compartment analysis block, GUI for computation parameter settings and results displays, data bases. The compartments are obtained by classifying various natural environments into groups that exhibit similar properties. A hypothetical combination of land usage was supposed to check the function of MOGRA. The land usage was consisted from cultivated lands, forests, uncultivated lands, urban area, river, and lake. Each land usage has its own inside model which is basic module. Also supposed was homogeneous contamination of the surface land from atmospheric deposition of $$^{137}$$Cs (1.0 Bq/m$$^{2}$$). The system analyzed the dynamic changes of $$^{137}$$Cs concentrations in each compartment, fluxes from one compartment to another compartment.

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