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forward transmission determined using a pulsed neutron beamNakabe, Rintaro*; Auton, C. J.*; Endo, Shunsuke; Fujioka, Hiroyuki*; Gudkov, V.*; Hirota, Katsuya*; Ide, Ikuo*; Ino, Takashi*; Ishikado, Motoyuki*; Kambara, Wataru*; et al.
Physical Review C, 109(4), p.L041602_1 - L041602_4, 2024/04
Times Cited Count：0 Percentile：0.00(Physics, Nuclear)-wave resonance of 
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Okudaira, Takuya*; Nakabe, Rintaro*; Auton, C. J.*; Endo, Shunsuke; Fujioka, Hiroyuki*; Gudkov, V.*; Ide, Ikuo*; Ino, Takashi*; Ishikado, Motoyuki*; Kambara, Wataru*; et al.
Physical Review C, 109(4), p.044606_1 - 044606_9, 2024/04
Times Cited Count：0 Percentile：0.00(Physics, Nuclear)Kageji, Teruyoshi*; Nagahiro, Shinji*; Mizobuchi, Keiji*; Toi, Hiroyuki*; Nakagawa, Yoshinobu*; Kumada, Hiroaki
Applied Radiation and Isotopes, 61(5), p.1063 - 1067, 2004/11
Times Cited Count：9 Percentile：52.01(Chemistry, Inorganic & Nuclear)no abstracts in English
Yamamoto, Kazuyoshi; Kumada, Hiroaki; Kishi, Toshiaki; Torii, Yoshiya; Sakurai, Yoshinori*; Kobayashi, Toru*
Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 15 Pages, 2004/10
To carry out the boron neutron capture therapy (BNCT) using the epithermal neutron, the epithermal neutron beam intensity was measured by using 
Au reaction rate activated on the resonance absorption peak (4.9eV). Two scaling factors, which are the reactor power calibration factor and the calculation/experiment (C/E) scaling factor, are necessary in order to correct with the simulation and actual irradiation experiment. First, an optimum detector position was investigated using MCNP code. The result of MCNP calculation showed that the influence of subject placed at the collimator was below 1% when the detector was placed in the distance of over 20cm from the collimator. Therefore we installed the monitor holders near the bismuth block in order to set three gold wire monitors. The factors were determined in the calibration experiments that measure the thermal neutron flux in the phantom and reaction rate of the gold wire monitors. The monitoring technique to measure epithermal neutron beam intensity was applied to clinical irradiation with the epithermal neutron beam.
Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya; Matsumura, Akira*; Nakagawa, Yoshinobu*
Japanese Journal of Medical Physics, Vol.23, Supplement 3, p.292 - 295, 2003/09
no abstracts in English
Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; Torii, Yoshiya; Shibata, Yasushi*; Nose, Tadao*
Radiation Research, 160(1), p.70 - 76, 2003/07
Times Cited Count：17 Percentile：45.18(Biology)The survival curves and the RBE for the dose components generated in boron neutron capture therapy (BNCT) were determined separately in neutron beams at JRR-4. The surviving fractions of V79 cells with or without 10B were obtained using an epithermal neutron beam (ENB), a mixed thermal-epithermal neutron beam (TNB-1), and a thermal (TNB-2) neutron beam. The cell killing effect of the neutron beam in the presence or absence of 10B was highly dependent on the neutron beam used and depended on the epithermal and fast-neutron content of the beam. The RBEs of the boron capture reaction were 4.07, 2.98 and 1.42, and the RBEs of the high-LET dose components based on the hydrogen recoils and the nitrogen capture reaction were 2.50, 2.34 and 2.17 for ENB, TNB-1 and TNB-2, respectively. The approach to the experimental determination of RBEs allows the RBE-weighted dose calculation for each dose component of the neutron beams and contributes to an accurate inter-beam comparison of the neutron beams at the different facilities employed in ongoing and planned BNCT clinical trials.
Nakajima, Ken; Yanagisawa, Hiroshi; Miyoshi, Yoshinori
JAERI-Tech 2003-028, 31 Pages, 2003/03
JAERI-Tech-2003-028.pdf:1.38MB
We have tried to measure the power profile in the TRACY supercritical experiment with high accuracy by detecting epithermal neutrons. In order to measure the epithermal neutrons, a cadmium covered 
U fission chamber was used, and polyethylene, a neutron moderator, was set inside the cadmium to enhance the neutron detection efficiency. In addition, a lead shield was used to reduce the noise current due to gamma-rays. The measured results were compared with the ones using a thermal neutron detector, and it was found that the time delay effect in the thermal neutron detection, which was caused by the flight time of neutrons to reach the detector, distorted the power profile and reduced its peak value. The reduction ratio of peak power was about 4% for the relatively slow power change with the inserted reactivity of 1.5$, but it became over than 40% for the rapid power change with the reactivity of about 3$.
Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya; Matsumura, Akira*; Yamamoto, Tetsuya*; Nose, Tadao*; Nakagawa, Yoshinobu*; Kageji, Teruyoshi*; Uchiyama, Junzo
JAERI-Tech 2003-002, 49 Pages, 2003/03
JAERI-Tech-2003-002.pdf:5.22MB
no abstracts in English
Kumada, Hiroaki; Torii, Yoshiya
JAERI-Data/Code 2002-018, 158 Pages, 2002/09
JAERI-Data-Code-2002-018.pdf:30.28MB
A boron neutron capture therapy (BNCT) with epithermal neutron beam is expected to treat effectively for malignant tumor that is located deeply in the brain. It is indispensable to estimate preliminarily the irradiation dose in the brain of a patient in order to perform the epithermal neutron beam BNCT. Thus, the JAERI Computational Dosimetry System (JCDS), which can calculate the dose distributions in the brain, has been developed. JCDS is a software that creates a 3-dimentional head model of a patient by using CT and MRI images and that generates a input data file automaticly for calculation neutron flux and gamma-ray dose distribution in the brain by the Monte Carlo code: MCNP, and that displays the dose distribution on the head model for dosimetry by using the MCNP calculation results. JCDS has any advantages as follows; By treating CT data and MRI data which are medical images, a detail three-dimensional model of patinet's head is able to be made easily. The three-dimensional head image is editable to simulate the state of a head after its surgical processes such as skin flap opening and bone removal for the BNCT with craniotomy that are being performed in Japan. JCDS can provide information for the Patient Setting System to set the patient in an actual irradiation position swiftly and accurately. This report describes basic design and procedure of dosimetry, operation manual, data and library structure for JCDS (ver.1.0)
Kumada, Hiroaki; Kishi, Toshiaki; Hori, Naohiko; Yamamoto, Kazuyoshi; Torii, Yoshiya
Research and Development in Neutron Capture Therapy, p.115 - 119, 2002/09
no abstracts in English
Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Matsushita, Akira*; Takano, Shingo*; Endo, Kiyoshi*; Akutsu, Hiroyoshi*; Yamamoto, Kazuyoshi; et al.
Research and Development in Neutron Capture Therapy, p.1073 - 1078, 2002/09
Since 1998 to 2002, a new clinical trial of an intraoperative boron neutron capture therapy (IOBNCT) at JRR-4 of Japan Atomic Energy Institute (JAERI) using BSH with mixed thermal/epithermal neutron beam has been accomplished. There have been 9 patients included in this study. The median survival time (MST) in GBM was 19.8 months and 16.8 months in AA. IOBNCT with mixed thermal/epithermal neutron beam provide better primary radiation effect than conventional therapy in selected cases. Our phase I/II clinical trial was effective in local tumor control. Further clinical trial with new design should be performed to prove the efficacy of IOBNCT.
Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; Torii, Yoshiya; Endo, Kiyoshi*; Matsushita, Akira*; Yoshida, Fumiyo*; Shibata, Yasushi*; et al.
Research and Development in Neutron Capture Therapy, p.697 - 700, 2002/09
The RBE of dose components generated in boron neutron capture therapy (BNCT) were separately determined in neutron beams at JRR-4. The cell killing effect of the neutron beam with or without the presence of 10B was highly dependent on the neutron beam used, according to the epithermal and fast neutron content in the beam. RBE (BARBEboron) values of the boron capture reaction for an epithermal (ENB), a mixed thermal-epithermal (TNB-1), and a thermal (TNB-2) neutron beams were 3.99
0.24, 3.040.19 and 1.430.08, respectively.
Matsushita, Akira*; Yamamoto, Tetsuya*; Matsumura, Akira*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Kashimura, Takanori*; Otake, Shinichi*
Research and Development in Neutron Capture Therapy, p.141 - 143, 2002/09
A thermal-epithermal mixed beam "Thermal Neutron Beam Mode I" was used in the eleven sessions of boron neutron capture therapy which have been performed at JRR-4 from 1998. We are planning to use an epithermal beam for the treatment of deeper tumors in the next trial of the intraoperative BNCT. In this study, "Epi-12" which was made by putting up a cadmium shutter of "Thermal Neutron Beam Mode I" was investigated for the clinical benefits and safety by epithermal beams. Decrease of fast neutron contamination ratio in Epi-12 mode is the advantage for BNCT, particular in the intraoperative BNCT. Because fast neutron on the brain surface is one of the critical factors in the intraoperative BNCT in which the plain beam directly interacts the normal structures. Furthermore a mixture of mode Epi-12 and Th-12 will provide various dose distribution designs. It may be used as a new method to control the best distribution for individual tumors.
Nakagawa, Yoshinobu*; Pooh, K. H.*; Kageji, Teruyoshi*; Uyama, Shinichi*; Kobayashi, Toru*; Sakurai, Yoshinori*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki
Research and Development in Neutron Capture Therapy, p.1113 - 1116, 2002/09
To make a new protocol using epithermal neutron beam for high-grade glioma patients, we elucidated the relationship between the radiation dose, histological tumor grade, and clinical outcome. One hundred and eighty-three patients with kinds of brain tumors were treated by BNCT since 1968, however, we performed a retrospective study of 105 patients with glial tumors treated in Japan between 1978 and 1997. As for the radiation side effect, we analyzed all patients(n=159) treated between 1977 and 2001. Ten patients with glioblastoma were treated according to the new protocol using epithermal neutron.
Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Shibata, Yasushi*; Nose, Tadao*
Physics in Medicine & Biology, 47(14), p.2387 - 2396, 2002/07
Times Cited Count：28 Percentile：59.67(Engineering, Biomedical)The aim of this study was to determine the in-phantom thermal distribution derived from neutron beams for intraoperative boron neutron capture therapy (IOBNCT). Gold activation wires arranged in a cylindrical water phantom with (void-in phantom) or without (standard phantom) a cylinder styrene form placed inside were irradiated by using the epithermal beam (ENB) and the mixed thermal-epithermal beam (TNB-1) at the JRR-4. The thermal neutron distribution derived from both the ENB and TNB-1 was significantly improved in the void-in-phantom, and a double high dose area was formed lateral to the void. The flattened distribution in the circumference of the void was observed with the combination of ENB and the void-in-phantom. The measurement data suggest that the ENB may provide a clinical advantage in the form of an enhanced and flattened dose delivery to the marginal tissue in which residual and/or microscopically infiltrating tumor.
Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Kishi, Toshiaki; Horiguchi, Yoji
JAERI-Tech 2001-015, 43 Pages, 2001/03
JAERI-Tech-2001-015.pdf:4.95MB
no abstracts in English
Nose, Tadao*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Yoshida, Fumiyo*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Matsushita, Akira*; Nakai, Kei*; Yamada, Takashi*; et al.
UTRCN-G-29, p.114 - 123, 2001/00
no abstracts in English
Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Hori, Naohiko; Kishi, Toshiaki; Takada, Juntaro*; Otake, S.*
Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.243 - 244, 2000/10
no abstracts in English
Nakai, K.*; Yamamoto, Tetsuya*; Matsumura, Akira*; Shibata, Yasushi*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; Torii, Yoshiya
Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.271 - 272, 2000/10
no abstracts in English
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JAERI-M 9552, 23 Pages, 1981/06
no abstracts in English
