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Journal Articles

Intraoperative boron neutron capture therapy using thermal/epithermal mixed beam

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Matsushita, Akira*; Takano, Shingo*; Endo, Kiyoshi*; Akutsu, Hiroyoshi*; Yamamoto, Kazuyoshi; et al.

Research and Development in Neutron Capture Therapy, p.1073 - 1078, 2002/09

Since 1998 to 2002, a new clinical trial of an intraoperative boron neutron capture therapy (IOBNCT) at JRR-4 of Japan Atomic Energy Institute (JAERI) using BSH with mixed thermal/epithermal neutron beam has been accomplished. There have been 9 patients included in this study. The median survival time (MST) in GBM was 19.8 months and 16.8 months in AA. IOBNCT with mixed thermal/epithermal neutron beam provide better primary radiation effect than conventional therapy in selected cases. Our phase I/II clinical trial was effective in local tumor control. Further clinical trial with new design should be performed to prove the efficacy of IOBNCT.

Journal Articles

Comparison of patient brain dose measurements and the JCDS calculation

Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Endo, Kiyoshi*; Matsushita, Akira*; Shibata, Yasushi*; Nose, Tadao*

Research and Development in Neutron Capture Therapy, p.415 - 418, 2002/09

Dose measurements in a patient's brain undergoing intraoperative BNCT (IOBNCT) were compared with calculations by a JAERI computational dosimetry system (JCDS). The maximum thermal neutron flux on the brain surface from the postirradiation measurement averaged 2.33$$pm$$0.37($$times$$10$$^{9}$$cm$$^{-2}$$s$$^{-1}$$) and the vascular boron dose averaged 11.4$$pm$$1.2 (9.6-12.7) Gy. Using JCDS, the maximum thermal neutron flux in the irradiated volume averaged 2.21$$pm$$0.33($$times$$10$$^{9}$$cm$$^{-2}$$s$$^{-1}$$), while the target vascular dose averaged 5.7 Gy and varied from 3.5 to 7.8 Gy. As such, in the dose planning for intra-operative irradiation, practical use of JCDS is recommended for uniform volume-dose control of postsurgical brain in IOBNCT.

Journal Articles

Intraoperative boron neturon capture therapy for malignant gliomas; First clinical results of Tsukuba phase I/II trial using JAERI mixed thermal-epithermal beam

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Matsushita, Akira*; Nakai, K.*; Yamada, Takashi*; Takano, Shingo*; Mizutani, Taro*; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.29 - 30, 2000/10

no abstracts in English

Journal Articles

Optimization of intraoperative (IO)BNCT; Pre-irradiation surgical technique and 2-D dosimetry in surgical field

Yasuda, Susumu*; Yamamoto, Tetsuya*; Matsumura, Akira*; Shibata, Yasushi*; Akutsu, Hiroyoshi*; Matsushita, Akira*; Nakai, K.*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.171 - 172, 2000/10

no abstracts in English

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