Application of invasion mathematical model in dosimetry for boron neutron capture therapy for malignant glioma

Yamamoto, Kazuyoshi; Kumada, Hiroaki; Nakai, Kei*; Endo, Kiyoshi*; Yamamoto, Tetsuya*; Matsumura, Akira*

Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 14 Pages, 2004/10

A dose distribution considered the tumor cell density distribution is required on the radiation therapy. We propose a novel method of determining target region considering the tumor cell concentration as a new function for the next generation Boron Neutron Capture Therapy (BNCT) dosimetry system. It has not been able to sufficiently define the degree of microscopic diffuse invasion of the tumor cells peripheral to a tumor bulk in malignant glioma using current medical imaging. Referring to treatment protocol of BNCT, the target region surrounding the tumor bulk has been set as the region which expands at the optional distance with usual 2cm margin from the region enhanced on T1 weighted gadolinium Magnetic Resonance Imaging (MRI). In this research, the cell concentration of the region boundary of the target was discussed by using tumor cell diffusion model in the sphere spatio-temporal system. The survival tumor cell density distribution after the BNCT irradiation was predicted by the two regions diffusion model for a virtual brain phantom.

Published literature on the research activities using the JMTR

Nagao, Yoshiharu; Ishii, Tadahiko; Takeda, Takashi; Fujiki, Kazuo

JAERI-Review 2002-007, 191 Pages, 2002/03

JAERI-Review-2002-007.pdf:10.97MB

The published reports on the research activities using the JMTR since 1971 to date have been surveyed by the search of literature database and questionnaire survey. This report summarized the result of survey as the title lists by research categories.

Irradiation-coupling techniques using JMTR and another facility

Matsui, Yoshinori; Itabashi, Yukio; Shimizu, Michio; Tsuji, Hirokazu

Journal of Nuclear Materials, 283-287(Part.2), p.997 - 1000, 2000/12

https://doi.org/10.1016/S0022-3115(00)00347-0

no abstracts in English

Annual report of JMTR, 1994 (April 1, 1994March 31, 1995)

Department of JMTR

JAERI-Review 96-004, 89 Pages, 1996/03

JAERI-Review-96-004.pdf:3.96MB

no abstracts in English

The Experiences and current situation on the development of irradiation technique in the JMTR projects

; ; Tsuyuzaki, Noriyoshi; ; Niimi, Motoji

Japan-China Symp. on Research and Test Reactors, 12 Pages, 1988/00

no abstracts in English

Grafting onto Cellulose by the Pre-irradiation Technique

; ;

Buletinul Institutului Politehnic din Iai, 16(20), p.273 - 278, 1970/00

no abstracts in English