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Journal Articles

Evaluation of the production amount of $$^{225}$$Ac and its uncertainty through the $$^{226}$$Ra(n,2n) reaction in the experimental fast reactor Joyo

Sasaki, Yuto*; Sano, Aaru; Sasaki, Shinji; Iwamoto, Nobuyuki; Ouchi, Kazuki; Kitatsuji, Yoshihiro; Takaki, Naoyuki*; Maeda, Shigetaka

Journal of Nuclear Science and Technology, 61(4), p.509 - 520, 2024/04

 Times Cited Count:4 Percentile:83.63(Nuclear Science & Technology)

$$^{225}$$Ac is attracting attention as an alpha-emitting medical radioisotope. Since its demand is expected to increase, domestic production of $$^{225}$$Ac is required from the viewpoint of Japan's medical research and economic security. To establish the technical bases for the $$^{225}$$Ac production, JAEA has evaluated the radioactivity that can be produced in the experimental fast reactor Joyo and designed the concept that upgrades the existing facilities for transporting the irradiated target from Joyo to a neighboring PIE facility rapidly. Efficient $$^{225}$$Ac Separation from $$^{226}$$Ra irradiated in a fast reactor was studied. Ba and La were used as alternatives to Ra and Ac, respectively. By using DGA resin as an adsorbent, it can be expected that Ra and impurities generated by irradiation will be removed and Ac will be isolated. This study has revealed that Joyo can sufficiently produce $$^{225}$$Ac as a raw material for pharmaceuticals.

Journal Articles

Sorption behavior of radium and actinium on soils

Sakamoto, Yoshiaki; Takebe, Shinichi; Ogawa, Hiromichi; Muraoka, Susumu; Ishii, Tomoaki*; Inagawa, Satoshi*; Gunji, Yasuyoshi*

Materials Research Society Symposium Proceedings, Vol.663, p.1207 - 1214, 2001/00

no abstracts in English

Journal Articles

Oral presentation

Medical RI production in existing reactors, 1; Ac-225 production in the core center/reflector region of the experimental fast reactor Joyo

Iwahashi, Daiki*; Sasaki, Yuto*; Maeda, Shigetaka; Takaki, Naoyuki*

no journal, , 

Ac-225 is attracting attention as a radioisotope for targeted $$alpha$$-therapy (TAT) used for the treatment of prostate cancer and the like. Therefore, we investigated a method of loading Ra-226 into the fast reactor Joyo and producing Ac-225 by transmutation. Ac-225 production can be expected by the (n,2n) reaction using fast neutrons in the center of the core and the (3n,$$alpha$$$$beta$$) reaction using thermalized neutrons in the reflector region.

Oral presentation

Medical RI production in existing reactors, 3; Comparison of medical RI production performances in Joyo and PWR

Takaki, Naoyuki*; Iwahashi, Daiki*; Sasaki, Yuto*; Maeda, Shigetaka

no journal, , 

We compared the production characteristics of Tc-99m and Ac-225 in the fast experimental reactor "Joyo" and commercial PWR, summarized the characteristics of each, and showed the possibility of domestic production of medical RI using domestic infrastructure.

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