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Journal Articles

Segmental motions of proteins under non-native states evaluated using quasielastic neutron scattering

Fujiwara, Satoru*; Matsuo, Tatsuhito*; Sugimoto, Yasunobu*; Shibata, Kaoru

Journal of Physical Chemistry Letters (Internet), 10(23), p.7505 - 7509, 2019/12

 Times Cited Count:0 Percentile:0.01(Chemistry, Physical)

Characterization of the dynamics of disordered polypeptide chains is required to elucidate the behavior of intrinsically disordered proteins and proteins under non-native states related to the folding process. Here we develop a method using quasielastic neutron scattering, combined with small-angle X-ray scattering and dynamic light scattering, to evaluate segmental motions of proteins as well as diffusion of the entire molecules and local side-chain motions. We apply this method to RNase A under the unfolded and molten-globule (MG) states. The diffusion coefficients arising from the segmental motions are evaluated and found to be different between the unfolded and MG states. The values obtained here are consistent with those obtained using the fluorescence-based techniques. These results demonstrate not only feasibility of this method but also usefulness to characterize the behavior of proteins under various disordered states.

Journal Articles

Dynamic properties of human $$alpha$$-synuclein related to propensity to amyloid fibril formation

Fujiwara, Satoru*; Kono, Fumiaki*; Matsuo, Tatsuhito*; Sugimoto, Yasunobu*; Matsumoto, Tomoharu*; Narita, Tetsuhiro*; Shibata, Kaoru

Journal of Molecular Biology, 431(17), p.3229 - 3245, 2019/08

 Times Cited Count:3 Percentile:27.91(Biochemistry & Molecular Biology)

$$alpha$$-synuclein ($$alpha$$Syn) is an intrinsically disordered protein (IDP) with unknown function. $$alpha$$Syn is known to form amyloid fibrils, which are implicated with the pathogenesis of Parkinson's disease and other synucleinopathies. Elucidating the mechanism of fibril formation of $$alpha$$Syn is therefore important for understanding the mechanism of the pathogenesis of these diseases. Here, using the quasielastic neutron scattering (QENS) and small-angle X-ray scattering (SAXS) techniques, we investigated the dynamic and structural properties of $$alpha$$Syn. These results imply that fibril formation of $$alpha$$Syn requires not only the enhanced local motions but also the segmental motions such that the proper inter-molecular interactions are possible.

Journal Articles

Measurement of neutron scattering cross section of nano-diamond with particle diameter of approximately 5 nm in energy range of 0.2 meV to 100 meV

Teshigawara, Makoto; Tsuchikawa, Yusuke*; Ichikawa, Go*; Takata, Shinichi; Mishima, Kenji*; Harada, Masahide; Oi, Motoki; Kawamura, Yukihiko*; Kai, Tetsuya; Kawamura, Seiko; et al.

Nuclear Instruments and Methods in Physics Research A, 929, p.113 - 120, 2019/06

 Times Cited Count:7 Percentile:75.46(Instruments & Instrumentation)

A nano-diamond is an attractive neutron reflection material below cold neutron energy. The total neutron cross section of a nano-diamond was derived from a neutron transmission measurement over the neutron energy range of 0.2 meV to 100 meV because total neutron cross section data were not available. The total cross section of a nano-diamond with particle size of approximately 5 nm increased with a decrease in neutron energy to 0.2 meV. It was approximately two orders of magnitude larger than that of graphite at 0.2 meV. The contribution of inelastic scattering to the total cross section was to be shown negligible small at neutron energies of 1.2, 1.5, 1.9, 2.6, and 5.9 meV in the inelastic neutron scattering measurement. Moreover, small-angle neutron scattering measurements of the nano-diamond showed a large scattering cross section in the forward direction for low neutron energies.

Journal Articles

Energy-resolved small-angle neutron scattering from steel

Oba, Yojiro*; Morooka, Satoshi; Oishi, Kazuki*; Suzuki, Junichi*; Takata, Shinichi; Sato, Nobuhiro*; Inoue, Rintaro*; Tsuchiyama, Toshihiro*; Gilbert, E. P.*; Sugiyama, Masaaki*

Journal of Applied Crystallography, 50(2), p.334 - 339, 2017/04

 Times Cited Count:2 Percentile:26.99(Chemistry, Multidisciplinary)

Journal Articles

Novel neutron scattering techniques using neutron transmission spectra

Oba, Yojiro*; Morooka, Satoshi; Sato, Hirotaka*; Sato, Nobuhiro*; Inoue, Rintaro*; Sugiyama, Masaaki*

Hamon, 26(4), p.170 - 173, 2016/11

Journal Articles

Magnetic scattering in the simultaneous measurement of small-angle neutron scattering and Bragg edge transmission from steel

Oba, Yojiro*; Morooka, Satoshi; Oishi, Kazuki*; Sato, Nobuhiro*; Inoue, Rintaro*; Adachi, Nozomu*; Suzuki, Junichi*; Tsuchiyama, Toshihiro*; Gilbert, E. P.*; Sugiyama, Masaaki*

Journal of Applied Crystallography, 49(5), p.1659 - 1664, 2016/10

 Times Cited Count:9 Percentile:63.8(Chemistry, Multidisciplinary)

Journal Articles

Elucidation of the morphology of the hydrocarbon multi-block copolymer electrolyte membranes for proton exchange fuel cells

Zhao, Y.; Yoshida, Miru*; Oshima, Tatsuya*; Koizumi, Satoshi*; Rikukawa, Masahiro*; Szekely, N.*; Radulescu, A.*; Richter, D.*

Polymer, 86, p.157 - 167, 2016/03

 Times Cited Count:12 Percentile:53.39(Polymer Science)

Journal Articles

A New high-resolution small-angle X-ray scattering apparatus using a fine-focus rotating anode,point-focusing collimation and a position-sensitive proportional counter

Journal of Applied Crystallography, 17, p.337 - 343, 1984/00

 Times Cited Count:12 Percentile:63.9(Chemistry, Multidisciplinary)

no abstracts in English

Journal Articles

Small angle scattering from neutron irradiated amorphous Pd$$_{8}$$$$_{0}$$ Si$$_{2}$$$$_{0}$$

; *; *

Journal of Applied Crystallography, 11(5), P. 605, 1978/00

no abstracts in English

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