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Journal Articles

Beam size reduction of a several hundred-keV compact ion microbeam system by improving the extraction condition in an ion source

Ishii, Yasuyuki; Okubo, Takeru; Kamiya, Tomihiro; Saito, Yuichi

Nuclear Instruments and Methods in Physics Research B, 348, p.79 - 82, 2015/04

 Times Cited Count:2 Percentile:20.69(Instruments & Instrumentation)

Journal Articles

Correction of X-ray detection yield in micro-PIXE analysis according to sample thickness variation measured by STIM

Sato, Takahiro; Sakai, Takuro; Oikawa, Masakazu*

Nuclear Instruments and Methods in Physics Research B, 249(1-2), p.234 - 237, 2006/08

 Times Cited Count:7 Percentile:48.48(Instruments & Instrumentation)

The purpose of this study is to correct yields of characteristic X-ray in micro-PIXE analysis by using STIM and computer simulation. To compensate the reduction of X-ray yields, thickness and internal constitution of a sample must be taken accurately with spatial resolution of a few microns. Therefore, we use STIM to investigate them. Furthermore, we developed a computer software code to correct the X-ray yields. To confirm validity of our method, ion exchange resins, which are similar to biological cells in size, were used as a test sample. There were some wrong distributions of sodium in micro-PIXE analysis of ion exchange resins. But, they could be corrected to some extent by using our code.

Journal Articles

Single-turn extraction technique for the JAERI AVF cyclotron

Kurashima, Satoshi; Miyawaki, Nobumasa; Okumura, Susumu; Ishibori, Ikuo; Yoshida, Kenichi; Kashiwagi, Hirotsugu; Fukuda, Mitsuhiro; Nara, Takayuki; Agematsu, Takashi; Nakamura, Yoshiteru

JAEA-Review 2005-001, TIARA Annual Report 2004, p.349 - 351, 2006/01

A flat-top acceleration system using fifth-harmonic frequency for the JAERI AVF cyclotron was developed to minimize the energy spread of an ion beam mainly for microbeam formation with a spot size of 1 micron in diameter by focusing with a set of quadrupole magnets. A single-turn extraction is an indispensable condition to reduce the energy spread without significant beam loss by the flat-top acceleration. In order to save time for the single-turn extraction tuning over measuring time distribution of the beam bunch, a deflector probe has been developed to observe the turn separation and the radial beam width. In this paper, we report the single-turn extraction technique with the deflector probe. As a result of beam developments, the single-turn extraction can be achieved in one or two hours and radioactivity of the deflector electrode can be also reduced in the acceleration of a high energy proton beam.

Journal Articles

Focused microbeam formation for heavy ion beam from AVF cyclotron

Yokota, Wataru; Sato, Takahiro; Oikawa, Masakazu*; Sakai, Takuro; Okumura, Susumu; Kurashima, Satoshi; Miyawaki, Nobumasa; Kashiwagi, Hirotsugu; Fukuda, Mitsuhiro

JAEA-Review 2005-001, TIARA Annual Report 2004, p.291 - 292, 2006/01

no abstracts in English

JAEA Reports

Proceedings of the 4th Workshop on Ion-beam-applied Biology; June 22, 2005, JAERI, Takasaki

Kobayashi, Yasuhiko; Funayama, Tomoo; Wada, Seiichi; Hamada, Nobuyuki*

JAERI-Conf 2005-012, 53 Pages, 2005/09

JAERI-Conf-2005-012.pdf:5.11MB

no abstracts in English

Journal Articles

Instrumentation for measurement of beam energy spread

Okumura, Susumu; Miyawaki, Nobumasa; Kurashima, Satoshi; Yoshida, Kenichi; Fukuda, Mitsuhiro; Ishibori, Ikuo; Agematsu, Takashi; Nara, Takayuki; Nakamura, Yoshiteru; Arakawa, Kazuo

Proceedings of 17th International Conference on Cyclotrons and Their Applications (CYCLOTRONS 2004), p.410 - 412, 2005/00

A simple analyzing system has been developed to measure the energy spread of the beam extracted from the JAERI AVF cyclotron with an energy resolution of dE/E = 0.001%. The high analyzing power can be obtained with an existing deflecting magnet system in the transport line by installing three sets of slits with a minimum width of 0.01 mm and a beam intensity monitor with a Faraday cup and semiconductor detectors. These new instruments have been compactly designed to fulfill the geometrical condition of the existing beam diagnostic chambers, which are located at the object and image positions. Installation of the analyzing system was completed and a preliminary test has been carried out. This system will be used for optimization of the flat-top acceleration system to achieve the energy spread of dE/E = 0.02%, required for microbeam production.

JAEA Reports

TIARA annual report 2003

Advanced Radiation Technology Center

JAERI-Review 2004-025, 374 Pages, 2004/11

JAERI-Review-2004-025-p0001-p0116.pdf:20.67MB
JAERI-Review-2004-025-p0117-p0247.pdf:21.34MB
JAERI-Review-2004-025-p0248-p0374.pdf:23.39MB

This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2003 to March 31, 2004. Summary reports of 115 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices.

Journal Articles

Development of a high-energy heavy ion microbeam system at the JAERI AVF cyclotron

Sato, Takahiro; Oikawa, Masakazu*; Sakai, Takuro; Okumura, Susumu; Kurashima, Satoshi; Miyawaki, Nobumasa; Fukuda, Mitsuhiro; Yokota, Wataru; Kamiya, Tomihiro

Proceedings of the 6th International Workshop on Radiation Effects on Semiconductor Devices for Space Application (RASEDA-6), p.207 - 210, 2004/10

A focused high-energy heavy ion scanning microbeam system with a spatial resolution of about 1$$mu$$m is being developed at the AVF cyclotron of JAERI-Takasaki. It will provide microbeams to applications such as radiation tolerance testing of semiconductor devices and radio microsurgery in biomedical science with single ion hit technique. The main system components (slits, a beam scanner, quadrupole magnets and so on) had been installed in 2002. Test operations have been carried out since last year. We report the results obtained so far.

JAEA Reports

TIARA annual report 2002

Advanced Radiation Technology Center

JAERI-Review 2003-033, 390 Pages, 2003/11

JAERI-Review-2003-033-p0001-p0187.pdf:18.1MB
JAERI-Review-2003-033-p0188-p0390.pdf:15.87MB

This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2002 to March 31, 2003. Summary reports of 113 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices.

Journal Articles

Beam development for flat-top acceleration in the JAERI AVF cyclotron

Kurashima, Satoshi; Miyawaki, Nobumasa; Fukuda, Mitsuhiro; Okumura, Susumu; Nara, Takayuki; Agematsu, Takashi; Ishibori, Ikuo; Yoshida, Kenichi; Nakamura, Yoshiteru; Arakawa, Kazuo

JAERI-Review 2003-033, TIARA Annual Report 2002, p.310 - 311, 2003/11

The JAERI AVF cyclotron provides a variety of ion beams especially for the research in biotechnology and materials science. Several cyclotron technologies such as cocktail beam acceleration, a uniform irradiation in a wide area and beam pulsation have been developed so far. A flat-top acceleration system for the JAERI AVF cyclotron has been designed to minimize the energy spread mainly for a microbeam production. The flat-top acceleration using fundamental and fifth-harmonic frequencies for an acceleration voltage is an excellent technique to reduce the energy spread.

Journal Articles

Design of a focusing high-energy heavy ion microbeam system at the JAERI AVF cyclotron

Oikawa, Masakazu*; Kamiya, Tomihiro; Fukuda, Mitsuhiro; Okumura, Susumu; Inoue, Hiromitsu*; Masuno, Shinichi*; Umemiya, Shinsuke*; Oshiyama, Yoshifumi*; Taira, Yutaka*

Nuclear Instruments and Methods in Physics Research B, 210(1-4), p.54 - 58, 2003/09

 Times Cited Count:23 Percentile:81.9(Instruments & Instrumentation)

no abstracts in English

Journal Articles

An Energy spread minimization system for microbeam generation in the JAERI AVF cyclotron

Fukuda, Mitsuhiro; Kurashima, Satoshi; Miyawaki, Nobumasa; Okumura, Susumu; Kamiya, Tomihiro; Oikawa, Masakazu*; Nakamura, Yoshiteru; Nara, Takayuki; Agematsu, Takashi; Ishibori, Ikuo; et al.

Nuclear Instruments and Methods in Physics Research B, 210, p.33 - 36, 2003/09

 Times Cited Count:4 Percentile:34.25(Instruments & Instrumentation)

A heavy ion microbeam with energy of hundreds MeV is a significantly useful probe for research in biotechnology. A single-ion hitting technique using a 260 MeV $$^{20}$$Ne$$^{7+}$$ microbeam is being developed at the JAERI AVF cyclotron facility for biofunction elucidation. Production of a microbeam with a spot size of one micro-meter in diameter requires reducing the energy spread of the beam to 0.02 % to minimize an effect of chromatic aberrations in focusing lenses. The typical energy spread of the cyclotron beam is around 0.1 % in an ordinary acceleration mode using a sinusoidal voltage waveform. The energy spread can be reduced by superimposing the fifth-harmonic voltage waveform on the fundamental one to generate a flattop waveform for uniform energy gain. We have designed an additional coaxial cavity to generate the fifth-harmonic voltage, coupled to the main resonator of one-fourth wavelength coaxial type. In a power test we successfully observed the fifth-harmonic voltage waveform by picking up an acceleration voltage signal.

Journal Articles

Bystander effect induced by counted high-LET particles in confluent human fibroblasts; A Mechanistic study

Shao, C.*; Furusawa, Yoshiya*; Kobayashi, Yasuhiko; Funayama, Tomoo; Wada, Seiichi

FASEB Journal, 17(11), p.1422 - 1427, 2003/08

 Times Cited Count:110 Percentile:87.57(Biochemistry & Molecular Biology)

The possible mechanism of a radiation-induced bystander response was investigated by using a high-LET heavy particle microbeam, which allows selected cells to be individually hit with precise numbered particles. Even when only a single cell within the confluent culture was hit by one particle of Ar40 or Ne20, a 1.4-fold increase of micronuclei (MN) was detected demonstrating a bystander response. When 49 cells in the culture were individually hit by 1 to 4 particles, the production of MN in the irradiated cultures were about 2-fold higher than control levels but independent of the number and LET of the particles. MN induction in the irradiated-culture was partly reduced by treatment with DMSO, a scavenger of reactive oxygen species (ROS), and it was almost fully suppressed by the mixture of DMSO and PMA, an inhibitor of gap junctional intercellular communication (GJIC). Accordingly, both ROS and GJIC contribute to the above-mentioned bystander response and GJIC might play an essential role by mediating the release of soluble biochemical factors from targeted cells.

Journal Articles

Flat-top acceleration system for the variable-energy multiparticle AVF cyclotron

Fukuda, Mitsuhiro; Kurashima, Satoshi; Okumura, Susumu; Miyawaki, Nobumasa; Agematsu, Takashi; Nakamura, Yoshiteru; Nara, Takayuki; Ishibori, Ikuo; Yoshida, Kenichi; Yokota, Wataru; et al.

Review of Scientific Instruments, 74(4), p.2293 - 2299, 2003/04

 Times Cited Count:14 Percentile:59.81(Instruments & Instrumentation)

A combination of the fundamental- and the fifth-harmonic voltages is ideally suited for flat-top acceleration in a variable-energy multi-particle cyclotron for energy-spread minimization. The flat-topping of the energy gain distribution using the fifth-harmonics has the advantages of minimizing an amplifier power, reducing power dissipation in a resonator and increasing the energy gain per turn. The flat-top acceleration system of the JAERI AVF cyclotron was designed to reduce the energy spread to 0.02 $$%$$, required for microbeam production. Tolerable fluctuations of acceleration voltages and the magnetic excitation were 2.0$$times$$10$$^{-4}$$ for the fundamental voltage, 1.0$$times$$10$$^{-3}$$ for the fifth-harmonic voltage, and 1.9$$times$$10$$^{-5}$$ for the magnetic field. In order to enhance compactness of the flat-topping cavity and to make a substantial saving of the amplifier power, optimum geometric parameters of the flat-topping cavity were determined by a cold model test and a calculation using the MAFIA code.

JAEA Reports

TIARA annual report 2001

Advanced Radiation Technology Center

JAERI-Review 2002-035, 361 Pages, 2002/11

JAERI-Review-2002-035-p0001-p0112.pdf:14.61MB
JAERI-Review-2002-035-p0113-p0236.pdf:19.49MB
JAERI-Review-2002-035-p0237-p0361.pdf:12.43MB

This annual report describes research and developement activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) Facilities from April 1, 2001 to March 31, 2002. Summary reports of 109 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices.

Journal Articles

Single event research at JAERI

Hirao, Toshio; Laird, J. S.; Mori, Hidenobu; Onoda, Shinobu; Wakasa, Takeshi; Yamakawa, Takeshi; Abe, Hiroshi; Ito, Hisayoshi

Proceedings of 5th International Workshop on Radiation Effects on Semiconductor Devices for Space Applications, p.161 - 166, 2002/10

no abstracts in English

Journal Articles

Use of collimated heavy ion microbeam for irradiating cells individually

Kobayashi, Yasuhiko; Taguchi, Mitsumasa; Watanabe, Hiroshi

Radiation Research, 153, p.228 - 229, 2000/00

no abstracts in English

Oral presentation

Fabrication of Mach-Zehnder optical waveguide structures in PDMS thin films using proton beam writing

Kano, Keisuke*; Saruya, Ryota*; Kawabata, Shunsuke*; Araki, Jun*; Noguchi, Katsuya*; Kada, Wataru*; Miura, Kenta*; Kato, Hijiri*; Sato, Takahiro; Koka, Masashi; et al.

no journal, , 

Oral presentation

Autophagy activated by Auger effect induced by soft X-ray microbeam

Noguchi, Miho; Yokoya, Akinari; Kaminaga, Kiichi; Fujii, Kentaro; Suzuki, Keiji*; Usami, Noriko*

no journal, , 

Oral presentation

Live cell imaging study on biological effects induced by X-ray microbeam irradiation

Kaminaga, Kiichi; Kanari, Yukiko*; Sakamoto, Yuka*; Noguchi, Miho; Narita, Ayumi*; Fujii, Kentaro; Usami, Noriko*; Kobayashi, Katsumi*; Suzuki, Keiji*; Yokoya, Akinari

no journal, , 

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