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Liu, S.*; Yang, D. S.*; Wang, S.*; Luan, H.*; Sekine, Yurina; Model, J. B.*; Aranyosi, A. J.*; Ghaffari, R.*; Rogers, J. A.*
EcoMat (Internet), 5(1), p.e12270_1 - e12270_18, 2023/01
Times Cited Count:7 Percentile:91.85(Chemistry, Physical)Advanced capabilities in noninvasive, in situ monitoring of sweat serve as the basis for obtaining real-time insights into human physiological state, health, and performance. Although recently reported microfluidic systems support powerful functions, most are designed as single-use disposables. Here, we introduce materials and molding techniques that bypass these concerns through biodegradable microfluidic systems with a full range of features. The key components fully degrade through the enzymatic action of microorganisms in natural soil environments. Detailed characterization of the device reveal a set of essential performance parameters that are comparable to, or even better than, those of non-degradable counterparts. Human subject studies illustrate the ability of these devices to acquire accurate measurements of sweat loss, sweat rate, pH, and chloride concentration.
Kim, S.*; Lee, B.*; Reeder, J. T.*; Seo, S. H.*; Lee, S.-U.*; Hourlier-Fargette, A.*; Shin, J.*; Sekine, Yurina; Jeong, H.*; Oh, Y. S.*; et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(45), p.27906 - 27915, 2020/11
Times Cited Count:62 Percentile:93.03(Multidisciplinary Sciences)In this study, we present a wireless, battery-free, skin-interfaced microfluidic system that combines lateral flow immunoassay for sweat cortisol assay, fluorometric imaging of glucose and ascorbic acid (vitamin C) assays, and digital tracking of sweat rate using electrodes that measure skin galvanic response. Systematic benchtop testing and on-body field studies on human subjects exercising in a gym environment highlight the key multifunctional features of this platform in tracking the biochemical correlates of physical stress.
Bandodkar, A. J.*; Gutruf, P.*; Choi, J.*; Lee, K.-H.*; Sekine, Yurina; Reeder, J. T.*; Jeang, W. J.*; Aranyosi, A. J.*; Lee, S. P.*; Model, J. B.*; et al.
Science Advances (Internet), 5(1), p.eaav3294_1 - eaav3294_15, 2019/01
Times Cited Count:386 Percentile:99.88(Multidisciplinary Sciences)Interest in advanced wearable technologies increasingly extends beyond systems for biophysical measurements to those that enable continuous, non-invasive monitoring of biochemical markers in biofluids. Here, we introduce battery-free, wireless microelectronic platforms that perform sensing via schemes inspired by the operation of biofuel cells. Combining these systems in a magnetically releasable manner with chrono-sampling microfluidic networks that incorporate assays based on colorimetric sensing yields thin, flexible, lightweight, skin-interfaced technologies with broad functionality in sweat analysis. A demonstration device allows simultaneous monitoring of sweat rate/loss, along with quantitative measurements of pH and of lactate, glucose and chloride concentrations using biofuel cell and colorimetric approaches.