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Journal Articles

Monte Carlo modelling for the ${it in vivo}$ lung monitoring of enriched uranium; Results of an international comparison

Broggio, D.*; Bento, J.*; Caldeira, M.*; Cardenas-Mendez, E.*; Farah, J.*; Fonseca, T.*; Konvalinka, C.*; Liu, L.*; Perez, B.*; Capello, K.*; et al.

Radiation Measurements, 47(7), p.492 - 500, 2012/07

 Times Cited Count:23 Percentile:84.01(Nuclear Science & Technology)

Journal Articles

Neutronics experiments on HCPB and HCLL TBM mock-ups in preparation of nuclear measurements in ITER

Batistoni, P.*; Angelone, M.*; Carconi, P.*; Fischer, U.*; Fleischer, K.*; Kondo, Keitaro; Klix, A.*; Kodeli, I.*; Leichtle, D.*; Petrizzi, L.*; et al.

Fusion Engineering and Design, 85(7-9), p.1675 - 1680, 2010/12

 Times Cited Count:31 Percentile:88.56(Nuclear Science & Technology)

The EU is developing two test blanket modules (TBM), the Helium Cooled Pebble Bed (HCPB) and the Helium Cooled Lithium Lead (HCLL), which will be tested in ITER. Here neutronics experiments with a mockup for HCLL TBM were carried out. Detail distributions of the tritium production rate inside the mockup were measured with various methods. A lithium diamond detector developed as a neutron monitor for fusion devices has also been used as a tritium detector. Activation reaction rates inside the mockup were also measured. These measured data agreed with calculation results buy using MCNP and FENDL-2.1 within 10%, which demonstrated that the prediction accuracy was high. Sensitivity and uncertainty analyses suggested that the uncertainty of the tritium production rate from the nuclear data uncertainty was small, usually below 2%.

Journal Articles

Limited concentration of RecA delays DNA double-strand break repair in ${it Deinococcus radiodurans}$ R1

Jolivet, E.*; Lecointe, F.*; Coste, G.*; Sato, Katsuya*; Narumi, Issei; Bailone, A.*; Sommer, S.*

Molecular Microbiology, 59(1), p.338 - 349, 2006/01

 Times Cited Count:38 Percentile:57.35(Biochemistry & Molecular Biology)

To evaluate the importance of RecA in DNA double strand break (DSB) repair, we examined the effect of low and high RecA concentration such as 2,500 and 100,000 molecules per cell from the inducible P${it spac}$ promoter in ${it Deinococcus radiodurans}$ in absence or in presence of IPTG, respectively. We showed that at low concentration, RecA has a negligible effect on cell survival after $$gamma$$-irradiation when bacteria were immediately plated on TGY agar whereas it significantly decreased the survival to $$gamma$$-irradiation of $$Delta$$${it ddrA}$ cells while overexpression of RecA can partially compensate the loss of DdrA protein. In contrast, when cells expressing limited concentration of RecA were allowed to recover in TGY liquid medium, they showed a delay in mending DSB, failed to reinitiate DNA replication and were committed to die during incubation in liquid medium. A deletion of ${it irrE}$ resulted in sensitivity to $$gamma$$-irradiation and mitomycin C treatment. Interestingly, constitutive high expression of RecA compensates partially the $$Delta$$ ${it irrE}$ sensitization to mitomycin C. The cells with low RecA content also failed to cleave LexA after DNA damage. However, neither a deletion of the ${it lexA}$ gene nor the expression of a non cleavable LexA(Ind$$^{-}$$) mutant protein, had an effect on survival or kinetics of DNA DSB repair compared to their ${it lexA}$ $$^{+}$$ counterparts in ${it recA}$ $$^{+}$$ as well as in bacteria expressing limiting concentration of RecA, suggesting an absence of relationship between the loss of viability, the delay in the kinetic of DSB repair, and the absence of LexA cleavage. Thus, LexA protein seems to play no major role in the recovery processes after $$gamma$$-irradiation in ${it D. radiodurans}$.

Journal Articles

The Structure of ${it D. radiodurans}$

Battista, J. R.*; Cox, M. M.*; Daly, M. J.*; Narumi, Issei; Radman, M.*; Sommer, S.*

Science, 302(24), p.567 - 568, 2003/10

no abstracts in English

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