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Ohshima, Hiroyuki; Morishita, Masaki*; Aizawa, Kosuke; Ando, Masanori; Ashida, Takashi; Chikazawa, Yoshitaka; Doda, Norihiro; Enuma, Yasuhiro; Ezure, Toshiki; Fukano, Yoshitaka; et al.
Sodium-cooled Fast Reactors; JSME Series in Thermal and Nuclear Power Generation, Vol.3, 631 Pages, 2022/07
This book is a collection of the past experience of design, construction, and operation of two reactors, the latest knowledge and technology for SFR designs, and the future prospects of SFR development in Japan. It is intended to provide the perspective and the relevant knowledge to enable readers to become more familiar with SFR technology.
Ito, Masayasu; Kawamata, Kazuo; Tayama, Yoshinobu; Kanazawa, Yoshiharu; Yonekawa, Minoru; Nakagawa, Tetsuya; Omi, Masao; Iwamatsu, Shigemi
JAEA-Technology 2011-022, 44 Pages, 2011/07
Hot laboratory are facilities that execute the post irradiation examination of sample irradiated in material testing reactors etc. The handling of high burn-up fuel is scheduled in the JMTR (Japan Materials Testing Reactor) Hot Laboratory with JMTR re-operate in FY 2011. This report describes evaluation, production and installation of shielding of the hot cells in the JMTR Hot Laboratory.
Ito, Takachika*; Suzuki, Shoichi*; Kanaji, Sachiko*; Shiraishi, Hiroshi*; Ota, Shoichiro*; Arima, Kazuhiko*; Tanaka, Go*; Tamada, Taro; Honjo, Eijiro*; Garcia, K. C.*; et al.
Journal of Biological Chemistry, 284(36), p.24289 - 24296, 2009/09
Times Cited Count:24 Percentile:45.24(Biochemistry & Molecular Biology)Both IL-4 and IL-13 can bind to the shared receptor composed of the IL-4 receptor chain and the IL-13 receptor -1 chain (IL-13R1); however, the assembly mechanisms of these ligands to the receptor is different, enabling the principal functions of these ligands to be different. We have previously shown that the N-terminal Ig-like domain in IL-13R1, called the D1 domain, is the specific and critical binding unit for IL-13. However, it has still remained obscure which the amino acid has specific binding capacity to IL-13 and why the D1 domain acts as the binding site for IL-13, but not IL-4. To address these questions, in this study, we performed the mutational analyses for the D1 domain, combining the structural data to identify the amino acids critical for binding to IL-13. Mutations of Lys76, Lys77, or Ile78 in c' strand in which the crystal structure showed interact with IL-13 and those of Trp65 and Ala79 adjacent to the interacting site, resulted in significant impairment of IL-13 binding, demonstrating that these amino acids generate the binding site. Furthermore, mutations of Val35, Leu38, or Val42 at N-terminal -strand also resulted in loss of IL-13 binding, probably from decrease structural stability. None of the mutations employed here affected IL-4 binding. These results demonstrate that the hydrophobic patch composed of Lys76, Lys77, and Ile78 is the IL-13 recognition site and solidify our understanding that the differential requirements of the D1 domain in IL-13R1 allows the shared receptor to respond differentially to IL-4 and IL-13.
Takahashi, Yoshihiro*; Oki, Takahiro*; Nagasawa, Takaharu*; Nakajima, Yasuhito*; Kawanabe, Ryu*; Onishi, Kazunori*; Hirao, Toshio; Onoda, Shinobu; Mishima, Kenta; Kawano, Katsuyasu*; et al.
Nuclear Instruments and Methods in Physics Research B, 260(1), p.309 - 313, 2007/07
Times Cited Count:4 Percentile:35.7(Instruments & Instrumentation)no abstracts in English
Watanabe, Kazuhiro; ; Aoyagi, Tetsuo; ; Fujiwara, Yukio; Honda, Atsushi; Inoue, Takashi; Ito, Takao; Kawai, Mikito; Kazawa, Minoru; et al.
Radiation Physics and Chemistry, 49(6), p.631 - 639, 1997/00
Times Cited Count:3 Percentile:30.34(Chemistry, Physical)no abstracts in English
Seno, Muneaki*; Ito, Kenji*; Ambo, Noriaki*; Fukaya, Masaaki*
PNC TJ1561 96-002, 54 Pages, 1996/02
None
Seno, Muneaki*; Ito, Kenji*; Ambo, Noriaki*; Fukaya, Masaaki*
PNC TJ1561 96-001, 367 Pages, 1996/02
None
Yokokura, Kenji; Kasugai, Atsushi; Sakamoto, Keishi; Takahashi, Koji; Tsuneoka, Masaki; Yamamoto, Takumi; Imai, Tsuyoshi; Nagashima, Takashi; Saito, Yasushi*; *; et al.
Purazuma, Kaku Yugo Gakkai-Shi, 71(8), p.760 - 771, 1995/08
no abstracts in English
Kasugai, Atsushi; Yokokura, Kenji; Sakamoto, Keishi; Tsuneoka, Masaki; Yamamoto, Takumi; Imai, Tsuyoshi; Saito, Yasushi*; *; *; Ebisawa, Katsuyuki*
Proceedings of the 19th International Conference on Infrared and Millimeter Waves, 0, p.295 - 296, 1994/00
no abstracts in English
; ; ; ; Takeda, Tatsuoki; ; ; *; ; ; et al.
JAERI-M 5385, 18 Pages, 1973/09
no abstracts in English
Ito, Masayasu; Kawamata, Kazuo; Iwamatsu, Shigemi; Hayashi, Koji; Kanazawa, Yoshiharu; Nakagawa, Tetsuya
no journal, ,
no abstracts in English
Taguchi, Taketoshi; Kato, Yoshiaki; Yonekawa, Minoru; Kanazawa, Yoshiharu; Ito, Masayasu; Kurosawa, Makoto; Aoyagi, Tatsuhiko; Tayama, Yoshinobu; Sozawa, Shizuo; Kawamata, Kazuo
no journal, ,
no abstracts in English