Estimation methods of blood boron concentration and error evaluation during boron neutron capture therapy for malignant brain tumor

Shibata, Yasushi*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Yamamoto, Tetsuya*; Hori, Naohiko; Kishi, Toshiaki; Kumada, Hiroaki; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, Kei*; et al.

JAERI-Research 2005-009, 41 Pages, 2005/03

JAERI-Research-2005-009.pdf:1.99MB

The measurement of neutron flux and boron concentration in the blood during medical irradiation is indispensable in order to evaluate the radiation in boron neutron capture therapy. It is, however, difficult to measure the blood boron concentration during neutron irradiation because access to the patient is limited. Therefore we prospectively investigated the predictability of blood boron concentrations using the data obtained at the first craniotomy after infusion of a low dosage of BSH. When the test could not be carried out, the blood boron concentration during irradiation was also predicted by using the 2-compartment model. If the final boron concentration after the end of the infusion is within 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%. If the final boron concentration at 6 or 9 hours after the end of infusion is out of 95% confidence interval of the prediction, proportional adjustment will reduce error and expected error after adjustment to around 12%.

Failure pattern in the patients who underwent intraoperative boron neutron capture therapy (IOBNCT)

Nakai, Kei*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Zhang, T.*; Akutsu, Hiroyoshi*; Matsuda, M.*; Matsushita, Akira*; Yasuda, Susumu*; Takano, Shingo*; et al.

Research and Development in Neutron Capture Therapy, p.1135 - 1138, 2002/09

7 patients have been undergoing Intraoperative boron neutron capture therapy (IOBNCT) for malignant glioma at Japan Atomic Energy Institute (JAERI). Post-BNCT MRI studies revealed one local recurrence and two distant recurrences. Distant recurrence is uncommon in the conventional radiation therapy. Symptomatic late radiation necrosis occurred in one case.

Basic and clinical studies for application of epithermal neutron beam for neutron capture therapy

Nose, Tadao*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Yoshida, Fumiyo*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Matsushita, Akira*; Nakai, Kei*; Yamada, Takashi*; et al.

UTRCN-G-29, p.114 - 123, 2001/00

no abstracts in English

Optimization of intraoperative (IO)BNCT; Pre-irradiation surgical technique and 2-D dosimetry in surgical field

Yasuda, Susumu*; Yamamoto, Tetsuya*; Matsumura, Akira*; Shibata, Yasushi*; Akutsu, Hiroyoshi*; Matsushita, Akira*; Nakai, K.*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.171 - 172, 2000/10

no abstracts in English