Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Hata, Kuniki; Urushibara, Ayumi*; Yamashita, Shinichi*; Lin, M.*; Muroya, Yusa*; Shikazono, Naoya; Yokoya, Akinari; Fu, H.*; Katsumura, Yosuke*
Journal of Radiation Research, 56(1), p.59 - 66, 2015/01
Times Cited Count：6 Percentile：29.71(Biology)Hata, Kuniki; Urushibara, Ayumi; Yamashita, Shinichi; Shikazono, Naoya; Yokoya, Akinari; Katsumura, Yosuke*
Biochemical and Biophysical Research Communications, 434(2), p.341 - 345, 2013/05
Times Cited Count：8 Percentile：23.93(Biochemistry & Molecular Biology)Kinjo, Tomohiro*; Nishikawa, Masabumi*; Yanashita, Naoya*; Koyama, Takanori*; Tanifuji, Takaaki*; Enoeda, Mikio
Fusion Engineering and Design, 82(15-24), p.2147 - 2151, 2007/10
Times Cited Count：22 Percentile：80.64(Nuclear Science & Technology)no abstracts in English
-ray irradiation to dilute aqueous solution of plasmid DNA; Chemical repair of radiation-induced lesions on DNA by antioxidant edaravoneHata, Kuniki; Urushibara, Ayumi; Yamashita, Shinichi; Shikazono, Naoya; Yokoya, Akinari; Katsumura, Yosuke*
no journal, ,
no abstracts in English
Hata, Kuniki; Urushibara, Ayumi; Yamashita, Shinichi; Shikazono, Naoya; Yokoya, Akinari; Muroya, Yusa*; Katsumura, Yosuke*
no journal, ,
In the present study we verify the chemical repair property of an antioxidant, edaravone. At first, edaravone radical was measured by pulse radiolysis method to confirm that edaravone reacts efficiently with dGMP radical. In order to verify the chemical repair of radicals in DNA macromolecules by edaravone we irradiated -ray to aqueous solutions of plasmid DNA. In addition to strand breaks we quantified the chemical yields of AP sites and base lesions using base excision repair enzymes. Production of AP sites and base lesions were more significantly inhibited than that of strand breaks by addition of edaravone. This result indicates that edaravone can chemically repair DNA radicals resulting in AP sites or base lesions on DNA.
