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Journal Articles

Technical estimation for mass production of highly-concentrated $^{rm 99m}$ Tc solution from $^{99}$ Mo to be obtained by () reaction; A Preliminary study using inactive Re instead of $^{rm 99m}$ Tc

Tanase, Masakazu*; Fujisaki, Saburo*; Ota, Akio*; Shiina, Takayuki*; Yamabayashi, Hisamichi*; Takeuchi, Nobuhiro*; Tsuchiya, Kunihiko; Kimura, Akihiro; Suzuki, Yoshitaka; Ishida, Takuya; et al.

Radioisotopes, 65(5), p.237 - 245, 2016/05

https://doi.org/10.3769/radioisotopes.65.237

no abstracts in English

Journal Articles

Preparation of polymer gel dosimeters based on less toxic monomers and gellan gum

Hiroki, Akihiro; Sato, Yuichi*; Nagasawa, Naotsugu; Ota, Akio*; Seito, Hajime; Yamabayashi, Hisamichi*; Yamamoto, Takayoshi*; Taguchi, Mitsumasa; Tamada, Masao; Kojima, Takuji

Physics in Medicine & Biology, 58(20), p.7131 - 7141, 2013/10

https://doi.org/10.1088/0031-9155/58/20/7131

Times Cited Count：17 Percentile：54.54(Engineering, Biomedical)

Journal Articles

Generation of radioisotopes with accelerator neutrons by deuterons

Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.

Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06

https://doi.org/10.7566/JPSJ.82.064201

Times Cited Count：43 Percentile：85.02(Physics, Multidisciplinary)

Journal Articles

Successful labeling of $^{rm 99m}$ Tc-MDP using $^{rm 99m}$ Tc separated from $^{99}$ Mo produced by $^{100}$ Mo(,2) $^{99}$ Mo

Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi*; Kawauchi, Yukimasa*; et al.

Journal of the Physical Society of Japan, 80(8), p.083201_1 - 083201_4, 2011/08

https://doi.org/10.1143/JPSJ.80.083201

Times Cited Count：15 Percentile：65.33(Physics, Multidisciplinary)

We have for the first time succeeded to separate $^{rm 99m}$ Tc from a Mo oxide sample irradiated by accelerator neutrons, and to formulate $^{rm 99m}$ Tc-methylene diphosphonate ( $^{rm 99m}$ Tc-MDP). $^{99}$ Mo, the mother nuclide of $^{rm 99m}$ Tc, was produced by the $^{100}$ Mo(,2) $^{99}$ Mo reaction using about 14 MeV neutrons provided at the Fusion Neutronics Source of Japan Atomic Energy Agency. The $^{rm 99m}$ Tc was separated from $^{99}$ Mo by the sublimation method, and its radionuclide purity was confirmed to be higher than 99.99%. The labeling efficiency of $^{rm 99m}$ Tc-MDP was shown to be higher than 99%. These values exceed the United States Pharmacopeia requirements for a fission product, $^{99}$ Mo. Consequently, a $^{rm 99m}$ Tc radiopharmaceutical preparation formed by using the mentioned $^{99}$ Mo can be a promising substitute for the fission product $^{99}$ Mo. A longstanding problem to ensure a reliable and constant supply of $^{99}$ Mo in Japan can be partially mitigated.

JAEA Reports

Feasibility study of sublimation type $^{99m}$ Tc master-milker; Comparison with PZC based wet method

Ishitsuka, Etsuo; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Norihito*; Hori, Naohiko; Awaludin, R.*; Gunawan, A. H.*; Lubis, H.*; Mutalib, A.*

JAEA-Technology 2011-019, 18 Pages, 2011/06

JAEA-Technology-2011-019.pdf:2.61MB

Feasibility study of sublimation type $^{99m}$ Tc master-milker was carried out as a $^{99}$ Mo/ $^{99m}$ T production development with the JMTR. As the feasibility study, the experimental equipment for sublimation method and wet method with PZC based $^{99m}$ Tc solution were tentatively manufactured, and their properties as the master-milker were investigated by comparing two methods with each other. As a result, it was found that the $^{99m}$ Tc recovery rate and process time of the sublimation method were about 80% and 1.5 hour, respectively, and the similar values were observed with the wet method. Superior points of the sublimation method are easier operation and reusability of the used MoO $_{3}$ comparing with the wet method. On the other hand, disadvantageous point is that the $^{99m}$ Tc recovery rate decreases with the increase of treating amount of MoO $_{3}$ .

JAEA Reports

Development of $^{rm 99m}$ Tc extraction techniques from $^{99}$ Mo by (n,) reaction

Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Yuichi*

JAEA-Review 2010-053, 23 Pages, 2010/11

JAEA-Review-2010-053.pdf:2.52MB

Production techniques of $^{99}$ Mo, parent nuclide of $^{rm 99m}$ Tc, have been developed for the industrial utilization as medical diagnosis medicine after the JMTR refurbishment. The (n,) method is proposed in JMTR because of low-amount radioactive wastes and easy $^{rm 99m}$ Tc production process. In this study, the production of the high-density MoO $_{3}$ pellet and concentration techniques of $^{rm 99m}$ Tc solution were developed. As the trial test, the MoO $_{3}$ pellets with high density were produced by the SPS (Spark Plasma Sintering) method. On the other hands, it was possible to concentrate $^{rm 99m}$ Tc solution by the solvent extraction using Methyl Ethyl Ketone (MEK). From the result, the $^{rm 99m}$ Tc concentrating device with more than 80% concentration efficiency, was performed successfully.

Journal Articles