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C and 
O nuclei by low-energy proton beamsAkagi, Takashi*; Yagi, Masashi*; Yamashita, Tomohiro*; Murakami, Masao*; Yamakawa, Yoshiyuki*; Kitamura, Keiji*; Ogura, Koichi; Kondo, Kiminori; Kawanishi, Shunichi*
Radiation Measurements, 59, p.262 - 269, 2013/12
Times Cited Count：16 Percentile：76.68(Nuclear Science & Technology)In proton therapy, positron emitters are induced from C andO nuclei by protons on the beam path in the patient. Many studies for monitoring positron emitters with beam-induced PET technique have been performed by various groups to verify the proton beam range and the dose in the patient for quality assurance. The aim of this study was to develop a method for measuring the production cross sections of positron emitters using standard equipment for proton therapy. The time-activity curve was then obtained with a high-sensitivity PET scanner to extract the number of positron emitters produced in the target. The production cross sections for four reaction channels: O(p,pn)
O, O(p,3p3n)
C, O(p,2p2n)
N, and C(p,pn)C were then measured. The cross sections for the O(p,pn)O reaction channel were consistent with data of previous experiments within the uncertainties, while those of C(p,pn)C were generally lower than data of previous experiments.
Yogo, Akifumi; Maeda, Takuya; Hori, Toshihiko; Sakaki, Hironao; Ogura, Koichi; Nishiuchi, Mamiko; Sagisaka, Akito; Bolton, P.; Murakami, Masao*; Kawanishi, Shunichi; et al.
Nuclear Instruments and Methods in Physics Research A, 653(1), p.189 - 192, 2011/10
Times Cited Count：9 Percentile：57.01(Instruments & Instrumentation)Yogo, Akifumi; Maeda, Takuya*; Hori, Toshihiko*; Sakaki, Hironao; Ogura, Koichi; Nishiuchi, Mamiko; Sagisaka, Akito; Bolton, P.; Murakami, Masao*; Kawanishi, Shunichi*; et al.
Proceedings of SPIE Europe Optics + Optoelectronics 2011, Vol.8079, 8 Pages, 2011/04
Yogo, Akifumi; Maeda, Takuya; Hori, Toshihiko; Sakaki, Hironao; Ogura, Koichi; Nishiuchi, Mamiko; Sagisaka, Akito; Kiriyama, Hiromitsu; Okada, Hajime; Kanazawa, Shuhei; et al.
Applied Physics Letters, 98(5), p.053701_1 - 053701_3, 2011/02
Times Cited Count：97 Percentile：94.23(Physics, Applied)Sutherland, K.*; Miyajima, Satoshi*; Date, Hiroyuki*; Shirato, Hiroki*; Ishikawa, Masayori*; Murakami, Masao*; Yamagiwa, Mitsuru; Bolton, P.; Tajima, Toshiki
Radiological Physics and Technology, 3(1), p.16 - 22, 2010/01
Yogo, Akifumi; Sato, Katsutoshi; Nishikino, Masaharu; Mori, Michiaki; Teshima, Teruki*; Numasaki, Hodaka*; Murakami, Masao*; Demizu, Yusuke*; Akagi, Takashi*; Nagayama, Shinichi*; et al.
Applied Physics Letters, 94(18), p.181502_1 - 181502_3, 2009/05
Times Cited Count：110 Percentile：94.75(Physics, Applied)Murakami, Masao*; Hishikawa, Yoshio*; Miyajima, Satoshi*; Okazaki, Yoshiko; Sutherland, K.*; Abe, Mitsuyuki*; Bulanov, S. V.; Daido, Hiroyuki; Esirkepov, T. Z.; Koga, J. K.; et al.
AIP Conference Proceedings 1024, p.275 - 300, 2008/08
no abstracts in English
Saito, Kimiaki; Saito, Hidetoshi*; Kunieda, Etsuo*; Narita, Yuichiro*; Myojoyama, Atsushi*; Fujisaki, Tatsuya*; Kawase, Takatsugu*; Kaneko, Katsutaro*; Ozaki, Masahiro*; Deloar, H. M.*; et al.
Joho Shori, 48(10), p.1081 - 1088, 2007/10
no abstracts in English
Yogo, Akifumi; Sato, Katsutoshi*; Nishikino, Masaharu; Mori, Michiaki; Teshima, Teruki*; Numasaki, Hodaka*; Murakami, Masao*; Ogura, Koichi; Sagisaka, Akito; Orimo, Satoshi; et al.
no journal, ,
In this work, we demonstrate the irradiation effect of laser accelerated protons induced on human lung cancer cells. In-vitro A549 cells are irradiated with a proton dose of 20 Gy, resulting in a distinct formation of 
-H2AX foci as an indicator of DNA double-strand breaks. This is the first result showing that laser-driven ion beams can generate a lethal effect on cancer cells.
Yogo, Akifumi; Sato, Katsutoshi*; Nishikino, Masaharu; Mori, Michiaki; Teshima, Teruki*; Numasaki, Hodaka*; Murakami, Masao*; Ogura, Koichi; Sagisaka, Akito; Orimo, Satoshi; et al.
no journal, ,
We have newly developed a proton-beam irradiation system driven by a high-intensity laser for biological studies. In the laser-ion acceleration, X-rays and electrons are generated simultaneously with the protons. In order to remove them, we equiped a magnetic analyzer in the irradiation system. Moreover, we developed a cell capsule, which was newly designed to insert in-vitro cell samples into the vacuum chamber used for the proton generation. We also report the result of 20-Gy proton irradiation of a human lung cancer cells.
Murakami, Masao*; Demizu, Yusuke*; Niwa, Yasue*; Nagayama, Shinichi*; Maeda, Takuya*; Baba, Masashi*; Miyawaki, Daisuke*; Terashima, Kazuki*; Arimura, Takeshi*; Mima, Masayuki*; et al.
no journal, ,
Yogo, Akifumi; Nishiuchi, Mamiko; Sakaki, Hironao; Hori, Toshihiko; Sato, Katsutoshi; Nishikino, Masaharu; Maeda, Takuya; Mori, Michiaki; Ogura, Koichi; Orimo, Satoshi; et al.
no journal, ,
no abstracts in English
Yogo, Akifumi; Sato, Katsutoshi; Nishikino, Masaharu; Maeda, Takuya; Nishiuchi, Mamiko; Sakaki, Hironao; Hori, Toshihiko; Mori, Michiaki; Ogura, Koichi; Orimo, Satoshi; et al.
no journal, ,
no abstracts in English
Bolton, P.; Abe, Mitsuyuki*; Akagi, Takashi*; Nuesslin, F.*; Hori, Toshihiko; Iwashita, Yoshihisa*; Kawanishi, Shunichi; Kondo, Kiminori; Maeda, Takuya; Molls, M.*; et al.
no journal, ,
Bolton, P.; Iwase, Hiroshi*; Akagi, Takashi*; Murakami, Masao*
no journal, ,
Maeda, Takuya; Yogo, Akifumi; Demizu, Yusuke*; Hori, Toshihiko; Sakaki, Hironao; Tomoe, Yusuke*; Kondo, Kiminori; Murakami, Masao*
no journal, ,
Yogo, Akifumi; Maeda, Takuya*; Hori, Toshihiko*; Sakaki, Hironao; Ogura, Koichi; Nishiuchi, Mamiko; Sagisaka, Akito; Bolton, P.; Murakami, Masao*; Kondo, Kiminori
no journal, ,
