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Oral presentation

Study of the PZC$$^{188}$$W/$$^{188}$$Re generator and of the synthesis condition of $$^{186/188}$$Re-DMSA

Nogawa, Norio*; Ikeda, Keishiro*; Morikawa, Naotake*; Motoishi, Shoji; Matsuoka, Hiromitsu; Hashimoto, Kazuyuki

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Rhenium-186(T$$_{1/2}$$=90h; E$$_beta$$=1.1 MeV; E$$_gamma$$=137 keV) and rhenium-188(T$$_{1/2}$$=17h; E$$_beta$$=2.1 MeV; E$$_gamma$$=153 keV) are $$beta$$$$^{-}$$ particle emitting radionuclides with excellent properties for targeted radiotherapy. Re-188 has the advantages associated with carrier-free, generator-produced radionuclides. PZC generator with many tungsten molecules is expected for as practical generator. This generator was experimented for clarifying a characteristic. Meso-2,3-dimercaptosuccinic acid (DMSA) is applied for palliative treatment of pain associated with disease. Effect of pH is studied on preparation of $$^{186/188}$$Re-DMSA.

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