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Journal Articles

Preparation and biological evaluation of 3-[$$^{76}$$Br]bromo-$$alpha$$-methyl-L-tyrosine, a novel tyrosine analog for PET imaging of tumors

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Sugo, Yumi; Watanabe, Satoshi; Tominaga, Hideyuki*; Oriuchi, Noboru*; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 91, 2012/01

Journal Articles

Preparation and biological evaluation of 3-[$$^{76}$$Br]bromo-$$alpha$$-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Sugo, Yumi; Watanabe, Satoshi; Tominaga, Hideyuki*; Oriuchi, Noboru*; Endo, Keigo*; Ishioka, Noriko

Nuclear Medicine and Biology, 38(6), p.857 - 865, 2011/08

 Times Cited Count:14 Percentile:47.43(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with $$^{64}$$Cu -labeled trastuzumab PET

Paudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.

JAEA-Review 2010-065, JAEA Takasaki Annual Report 2009, P. 108, 2011/01

Journal Articles

First neutron production utilizing J-PARC pulsed spallation neutron source JSNS and neutronic performance demonstrated

Maekawa, Fujio; Harada, Masahide; Oikawa, Kenichi; Teshigawara, Makoto; Kai, Tetsuya; Meigo, Shinichiro; Oi, Motoki; Sakamoto, Shinichi; Takada, Hiroshi; Futakawa, Masatoshi; et al.

Nuclear Instruments and Methods in Physics Research A, 620(2-3), p.159 - 165, 2010/08

 Times Cited Count:73 Percentile:97.63(Instruments & Instrumentation)

The J-PARC 1-MW pulsed spallation neutron source JSNS was successfully launched on 30th of May 2008. To demonstrate the unique features of the moderator design and the neutronic performance of JSNS the neutron spectral intensity, absolute neutron flux, and time structure of the neutron pulse shapes etc have been measured using several neutron instruments since then. The measured energy spectra clearly revealed the feature of the para-hydrogen, as expected when designing the moderator. The measured neutron flux below 0.4 eV agreed with the corresponding design value within $$pm$$20%, thus suggesting that the JSNS design calculations to have been reliable. World-class high-resolution diffraction data could be recorded due to the suitability of design of the moderators and the instruments. Another world-class high-intensity neutron flux was also capable of being demonstrated due to the unique design of the large cylindrical coupled moderator.

Journal Articles

Distinctive features in neutronic performance of JSNS

Maekawa, Fujio; Oikawa, Kenichi; Harada, Masahide; Teshigawara, Makoto; Kai, Tetsuya; Kasugai, Yoshimi; Meigo, Shinichiro; Oi, Motoki; Futakawa, Masatoshi; Watanabe, Noboru*; et al.

Proceedings of 19th Meeting of the International Collaboration on Advanced Neutron Sources (ICANS-19) (CD-ROM), 8 Pages, 2010/07

Efforts have been made to characterize neutronic performance of JSNS. A NOBORU instrument was mainly used for this purpose while some other instruments were used when needed. The followings were confirmed. (1) Judging from a measured spectral shape, a para-hydrogen fraction in the hydrogen moderator was very close to unity as expected due to introduction of catalyst in a hydrogen circulation system. (2) Measured data for absolute spectral intensity and pulse shapes agreed very well with simulation calculations, and suggested adequacy of the neutron source designs. (3) The world's highest resolution of 0.035 % was recorded at the powder diffractometer SuperHRPD. (4) A total neutron flux of 3 $$times$$ 10$$^{9}$$n/s/cm$$^{2}$$ was confirmed at the chopper instrument 4SEASONS when it was normalized to 1 MW. The flux is the world's highest among existing spallation neutron sources, and is comparable to fluxes at intense reactor sources even in time-averaged value.

Journal Articles

Measurement of neutronic characteristics of JSNS

Harada, Masahide; Oikawa, Kenichi; Maekawa, Fujio; Meigo, Shinichiro; Futakawa, Masatoshi; Watanabe, Noboru*

Proceedings of 19th Meeting of the International Collaboration on Advanced Neutron Sources (ICANS-19) (CD-ROM), 8 Pages, 2010/07

To validate the neutronics design of JSNS, we measured neutron spectra at all available neutron beam lines by CTOF method. Measured values were in good agreement with evaluated ones for beam lines without guide tubes. Some discrepancies in spectral intensity were found in some of beam lines using a neutron guide tube. This result indicates that the CTOF method is very effective for checking initial installation of beam lines because neutron spectral intensity can be measured systematically in a short time. Furthermore, by measuring neutron spectral intensity with the CTOF method, we studied change of neutronic performance due to changes of operation conditions of JSNS such as incident proton beam conditions (position, profile and energy) and moderator temperature. These operation parameter dependences on neutronic performance were compared with calculated ones, and confirmed good agreements between them. This indicated reliability of neutronics design of JSNS.

Journal Articles

Imaging experiments on NOBORU at MLF

Harada, Masahide; Oikawa, Kenichi; Oi, Motoki; Kai, Tetsuya; Sakai, Kenji; Maekawa, Fujio; Watanabe, Noboru*; Shinohara, Takenao; Takata, Shinichi

Proceedings of 19th Meeting of the International Collaboration on Advanced Neutron Sources (ICANS-19) (CD-ROM), 10 Pages, 2010/07

A neutron beam line NOBORU built at MLF in J-PARC is suitable for imaging experiments due to a large beam size, a short distance from the moderator to the sample position and an adequate experimental room. In order to evaluate suitability for the imaging experiments, we measured neutron spectral intensities and flux distributions at the sample position of NOBORU. We also measured those quantities with use of some filters, collimators and slits equipped on NOBORU. As preliminary experiments for imaging, we measured Bragg edge transmission of some alloys and resonance absorption of some elements. The result showed welded and non-welded areas in an alloy could be clearly distinguished by the Bragg edge transmission. It was also found that several elements in the sample could be distinguished clearly by the resonance absorption method. It could be concluded that NOBORU was very suitable for the imaging experiments at J-PARC.

Journal Articles

Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with $$^{64}$$Cu-labeled trastuzumab PET

Paudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.

Cancer Science, 101(4), p.1045 - 1050, 2010/04

 Times Cited Count:38 Percentile:66.64(Oncology)

Journal Articles

Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; Yoshioka, Hiroki*; Yamamoto, Shinji*; Paudyal, P.*; Paudyal, B.*; Higuchi, Tetsuya*; et al.

JAEA-Review 2009-041, JAEA Takasaki Annual Report 2008, P. 108, 2009/12

Journal Articles

NOBORU; J-PARC BL10 for facility diagnostics and its possible extension to innovative instruments

Maekawa, Fujio; Oikawa, Kenichi; Harada, Masahide; Kai, Tetsuya; Meigo, Shinichiro; Kasugai, Yoshimi; Oi, Motoki; Sakai, Kenji; Teshigawara, Makoto; Hasegawa, Shoichi; et al.

Nuclear Instruments and Methods in Physics Research A, 600(1), p.335 - 337, 2009/02

 Times Cited Count:42 Percentile:92.92(Instruments & Instrumentation)

A neutron beam line (BL10) of JSNS, NOBORU, has been constructed in the Materials and Life Science Experimental Facility (MLF) at J-PARC. A primal mission of NOBORU is to study neutronic performance of JSNS. We will measure the memorable first neutron pulse of JSNS at the Day-one by using NOBORU, and then measure neutron pulse shape, spectrum, intensity distribution, etc. for facility diagnostics. Since NOBORU also has an aspect as a test port, it welcomes trial uses to develop innovative instruments. Trial experiments to demonstrate several innovative instruments at NOBORU are under planning.

Journal Articles

Pulse characteristics of epithermal neutrons from a spallation source

Harada, Masahide; Watanabe, Noboru*; Maekawa, Fujio; Futakawa, Masatoshi

Nuclear Instruments and Methods in Physics Research A, 597(2-3), p.242 - 256, 2008/12

 Times Cited Count:5 Percentile:38.68(Instruments & Instrumentation)

This paper discusses the feasibility of the use of epi-thermal neutrons from hydrogen moderators installed at a MW-class spallation neutron source. Pulse characteristics of epi-thermal neutrons at JSNS are studied by comparing with a reference light water moderator, which does not exist but is optimized at the JSNS target-moderator-reflector geometry. The performance in figure of merit expected from the JSNS hydrogen moderators at an epi-thermal neutron region are found to be 50% $$sim$$ 100%, depending on the neutron energy, compared to the reference light water moderator. JSNS could also be useful as an epi-thermal neutron source, although it was mainly designed as a cold and thermal neutron sources for the condensed matter research.

Journal Articles

Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Paudyal, P.*; Paudyal, B.*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Matsuhashi, Shimpei; Yoshioka, Hiroki*; Higuchi, Tetsuya*; et al.

JAEA-Review 2008-055, JAEA Takasaki Annual Report 2007, P. 114, 2008/11

Journal Articles

Design and application of NOBORU; NeutrOn Beam line for Observation and Research Use at J-PARC

Oikawa, Kenichi; Maekawa, Fujio; Harada, Masahide; Kai, Tetsuya; Meigo, Shinichiro; Kasugai, Yoshimi; Oi, Motoki; Sakai, Kenji; Teshigawara, Makoto; Hasegawa, Shoichi; et al.

Nuclear Instruments and Methods in Physics Research A, 589(2), p.310 - 317, 2008/05

 Times Cited Count:52 Percentile:95.04(Instruments & Instrumentation)

NOBORU, NeutrOn Beam-line for Observation and Research Use, has been constructed in the Materials and Life Science Facility (MLF) of J-PARC. NOBORU is designed to "Observe" a 1 MW Japan Spallation Neutron Source (JSNS), i.e., to study the neutronic performance of JSNS. NOBORU also will be used for "Research" activities, i.e., as a test port for R&D activities and trial users who have new ideas. In this paper, the design and application of NOBORU are described, and its expected performance is investigated by Monte Carlo simulations.

Journal Articles

Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Katabuchi, Tatsuya*; Watanabe, Shigeki; Ishioka, Noriko; Watanabe, Satoshi; Matsuhashi, Shimpei; Higuchi, Tetsuya*; Oriuchi, Noboru*; Endo, Keigo*

JAEA-Review 2007-060, JAEA Takasaki Annual Report 2006, P. 128, 2008/03

Journal Articles

Neutronics of a poisoned para-hydrogen moderator for a pulsed spallation neutron source

Harada, Masahide; Watanabe, Noboru*; Teshigawara, Makoto; Kai, Tetsuya; Kato, Takashi; Ikeda, Yujiro

Nuclear Instruments and Methods in Physics Research A, 574(3), p.407 - 419, 2007/05

 Times Cited Count:13 Percentile:68.48(Instruments & Instrumentation)

Neutronic performance of a poisoned hydrogen moderator was studied in details. Using a simple rectangular-shape moderator-model, its basic characteristics were studied as a function of the poison position. We, for the first time, turned up that the pulse width was rather decreasing with increasing the moderator thickness of the back part from the poison. This is due to the fact that source neutron pulses entering through the back part of poison are narrow while those from the target and the reflector through the decoupler and liner are broad. Next, we studied the pulse deterioration in regard to a finite beam-extraction-angle by using a canteen shape and a concave shape. It turns out that the pulse deterioration is large in both cases even at a small extraction angle. The concave-shape moderator indicates a finite improvement compared to the canteen shape one. Finally, merits and demerits of two poison materials, Cd and Gd, were discussed considering the burn-up issue of poison.

Journal Articles

Production of radioisotopes for nuclear medicine using ion beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Katabuchi, Tatsuya*; Watanabe, Satoshi; Ishioka, Noriko; Matsuhashi, Shimpei; Oriuchi, Noboru*; Higuchi, Tetsuya*; Miyakubo, Mitsuyuki*; Endo, Keigo*

JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 165, 2007/02

Journal Articles

Experimental program at a neutron beam line ${it NOBORU}$ in JSNS

Maekawa, Fujio; Oikawa, Kenichi; Harada, Masahide; Kai, Tetsuya; Meigo, Shinichiro; Kasugai, Yoshimi; Oi, Motoki; Sakai, Kenji; Teshigawara, Makoto; Hasegawa, Shoichi; et al.

Proceedings of 18th Meeting of the International Collaboration on Advanced Neutron Sources (ICANS-18) (CD-ROM), p.118 - 126, 2007/00

One of 23 neutron beam lines of JSNS, NOBORU, has been assigned to the Neutron Facility Group of JAEA. The primary mission of NOBORU is to investigate neutronic performance of JSNS while it can accommodate various trial research experiments. This paper describes an experimental program by using NOBORU mostly in an on-beam commissioning period of JSNS after the first proton beam acceptance in 2008. Topics for the primary mission to be studied are as follows; relationships between operating parameters of JSNS and neutronic performance, acquisition of beam parameters for users, confirmation of integrity in main components of JSNS, validation of neutronic designs, and research and development on measuring techniques. In addition, we are interested in radiography, introduction of a high-pressure instrument and eV neutron spectroscopy, and also welcome trial uses to bring out new research activities.

Journal Articles

Nuclear heating calculation for JSNS

Harada, Masahide; Maekawa, Fujio; Teshigawara, Makoto; Watanabe, Noboru*; Kato, Takashi; Ikeda, Yujiro

Proceedings of 18th Meeting of the International Collaboration on Advanced Neutron Sources (ICANS-18) (CD-ROM), p.616 - 626, 2007/00

no abstracts in English

Journal Articles

${it In situ}$ hydraulic tests in the active fault survey tunnel, Kamioka mine, excavated through the active Mozumi-Sukenobe fault zone and their hydrogeological significance

Nohara, Tsuyoshi; Tanaka, Hidemi*; Watanabe, Kunio*; Furukawa, Noboru*; Takami, Akira*

Island Arc, 15(4), p.537 - 545, 2006/12

 Times Cited Count:4 Percentile:13.62(Geosciences, Multidisciplinary)

The spatial hydrogeological and structural character of the active Mozumi-Sukenobu Fault (MSF) was investigated along a survey tunnel excavated through the MSF in the Kamioka Mine, Central Japan. Major groundwater conduits on both sides of the MSF are recognized. One is considered to be a sub-vertical conduit between the tunnel and the surface, the other is estimated to be a major reservoir of old meteoric water alongside the MSF. Studies indicate that part of the MSF is a sub-vertical continuous barrier that obstructs younger meteoric water observed in the southeastern part of the Active Fault Survey Tunnel (AFST) and recharge to the rock mass intersected by the northwestern part of the AFST. It is considered that the MSF is a continuous barrier resulting in the storage of a large quantity of older groundwater to the northwest. The observations indicate that the major reservoir is not the fault breccia associated with the NE-SW oriented faults of the MSF. Rather, the reservoir is considered to be the zone in which blocks of fractured rocks occur beside high angle faults corresponding to X shears that coincide in orientation with the present-day regional stress field and antithetic Riedel shears of the MSF. It is considered that secondary porosity is developed in the major reservoir by the destruction of filling minerals and fracture development beside these shears. The results of borehole investigations in the AFST indicate that increase in hydraulic conductivity is not directly related to increased density of fractures around the MSF. Our results suggested that minor conduits are sporadically distributed in the sedimentary rocks around the MSF in the AFST.

Journal Articles

Design of "NeutrOn Beam-line for Observation & Research Use (NOBORU)" for JSNS of J-PARC

Maekawa, Fujio; Oikawa, Kenichi; Tamura, Masaya; Harada, Masahide; Ikeda, Yujiro; Watanabe, Noboru

LA-UR-06-3904, Vol.1, p.129 - 138, 2006/06

Total 23 neutron beam-lines will be installed for JSNS in the J-PARC project. One of them is assigned for the Materials and Life Science Facility (MLF), and the MLF will construct a neutron beam-line to demonstrate and monitor neutronic performance of JSNS. The neutron beam-line was accordingly named as "Neutron Beam-line for Obserbation and Research Use (NOBORU)". Major parts of the NOBORU, i.e., beam ducts, shield, a beam stop, slits, a cabin for measurement, a pillar crane, a sample table, etc., have been ordered in March 2004, and installation will be completed in 2007. A T0 chopper, a frame-overlap chopper, detector systems, samples, etc. will be ordered later on. The sample position is at 14 m from the decoupled moderator. Approximate sample room dimensions are 3 $$times$$ 2.5 m in area and 3 m in height. A shield structure was determined by shielding calculations in which detailed 3-D structure was considered. The design of NOBORU will be presented in the session.

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