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Journal Articles

Corrosion behavior of iron-chrome alloys in liquid bismuth

Takai, Toshihide; Furukawa, Tomohiro; Watanabe, Shigeki*; Ishioka, Noriko*

Mechanical Engineering Journal (Internet), 9(4), p.21-00397_1 - 21-00397_11, 2022/08

For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, the National Institute for Quantum and Radiological Science and Technology has proposed the innovative "Liquid Bismuth Target System." The target window in this system must be made from a material that resists the highly corrosive liquid bismuth environment. To meet this requirement, a promising target window material was selected in corrosion experiments performed in stagnant liquid bismuth. Based on knowledge of corrosion in liquid lead-bismuth eutectic gained during the development of fast reactors and accelerator-driven subcritical systems, experiments were carried out under saturated dissolved oxygen and low oxygen conditions, and the corrosion behaviors of the specimens were evaluated. The FeCrAl-alloy exhibited the most excellent corrosion resistance, followed by FeCrMo-alloy. Both materials are suitable candidates for the target window.

Journal Articles

Medical application of radiohalogenated peptides; Synthesis and ${it in vitro}$ evaluation of F(${it p}$-$$^{131}$$I)KCCYSL for targeting HER2

Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Sugo, Yumi; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ishioka, Noriko

Peptide Science 2015, p.243 - 246, 2016/03

Journal Articles

Simultaneous analysis of silicon and boron dissolved in water by combination of electrodialytic salt removal and ion-exclusion chromatography with corona charged aerosol detection

Mori, Masanobu*; Sagara, Katsuya*; Arai, Kaori*; Nakatani, Nobutake*; Ohira, Shinichi*; Toda, Kei*; Itabashi, Hideyuki*; Kozaki, Daisuke*; Sugo, Yumi; Watanabe, Shigeki; et al.

Journal of Chromatography A, 1431, p.131 - 137, 2016/01

 Times Cited Count:10 Percentile:41.68(Biochemical Research Methods)

Journal Articles

Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for $$alpha$$ radionuclide therapy

Ogawa, Kazuma*; Mizuno, Yoshiaki*; Washiyama, Koshin*; Shiba, Kazuhiro*; Takahashi, Naruto*; Kozaka, Takashi*; Watanabe, Shigeki; Shinohara, Atsushi*; Odani, Akira*

Nuclear Medicine and Biology, 42(11), p.875 - 879, 2015/11

 Times Cited Count:23 Percentile:70.83(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

A Record of my sabbatical at the University of Washington, Seattle

Watanabe, Shigeki

Hoshasen To Sangyo, (138), p.52 - 54, 2015/06

no abstracts in English

Journal Articles

Production and separation of astatine isotopes in the $$^7$$Li + $$^{nat}$$Pb reaction

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Maeda, Eita*; Watanabe, Shigeki; Hashimoto, Kazuyuki; Ishioka, Noriko; Makii, Hiroyuki; Toyoshima, Atsushi; Yamada, Norihiro*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 304(3), p.1077 - 1083, 2015/06

 Times Cited Count:9 Percentile:60.64(Chemistry, Analytical)

Production cross sections of astatine isotopes $$^{207-211}$$At in the 29-57 MeV $$^7$$Li induced reaction with $$^{nat}$$Pb target have been measured by $$alpha$$- and $$gamma$$-ray spectrometry. Excitation functions of production cross sections have been compared with a statistical model calculation to study the reaction mechanism of $$^7$$Li + $$^{nat}$$Pb. Considerably small experimental cross sections of $$^{210}$$At and $$^{209}$$At compared with the calculation were clearly observed at incident energies higher than 44 MeV, indicating that the effects of breakup reaction play a role. A chemical separation of astatine from an irradiated lead target has been studied with a dry-distillation method. A complementary way to produce astatine isotopes has been developed.

Journal Articles

Development of a widely usable amino acid tracer; $$^{76}$$Br-$$alpha$$-methyl-phenylalanine for tumor PET imaging

Hanaoka, Hirofumi*; Ohshima, Yasuhiro; Suzuki, Yurika*; Yamaguchi, Aiko*; Watanabe, Shigeki; Uehara, Tomoya*; Nagamori, Shushi*; Kanai, Yoshikatsu*; Ishioka, Noriko; Tsushima, Yoshito*; et al.

Journal of Nuclear Medicine, 56(5), p.791 - 797, 2015/05

 Times Cited Count:18 Percentile:62.62(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Synthesis and ${{it in vitro}}$ evaluation of $$^{64}$$Cu-labeled peptide for tumor imaging

Sugo, Yumi; Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Ishioka, Noriko

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 100, 2015/03

Journal Articles

Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope; Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions

Sasaki, Ichiro; Hanaoka, Hirofumi*; Yamada, Keiichi*; Watanabe, Shigeki; Sugo, Yumi; Ohshima, Yasuhiro; Suzuki, Hiroyuki; Ishioka, Noriko

Peptide Science 2014, p.257 - 260, 2015/03

Journal Articles

Production of highly purified no-carrier-added $$^{177}$$Lu for radioimmunotherapy

Watanabe, Satoshi; Hashimoto, Kazuyuki; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

Journal of Radioanalytical and Nuclear Chemistry, 303(1), p.935 - 940, 2015/01

 Times Cited Count:11 Percentile:67.3(Chemistry, Analytical)

Journal Articles

Synthesis of radiohalogen-labeled peptide with high affinity to HER2/neu receptor

Sasaki, Ichiro; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Sugo, Yumi; Oku, Hiroyuki*; Ishioka, Noriko

JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 96, 2014/03

Journal Articles

Synthesis and ${it in vitro}$ Evaluation of $$^{64}$$Cu-labeled peptide for tumor imaging

Sugo, Yumi; Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Ishioka, Noriko

Peptide Science 2013, p.355 - 358, 2014/03

Journal Articles

Evaluation of a wet chemistry method for isolation of cyclotron produced [$$^{211}$$At] astatine

Balkin, E. R.*; Hamlin, D. K.*; Gagnon, K.*; Chyan, M.-K.*; Pal, S.*; Watanabe, Shigeki; Wilbur, D. S.*

Applied Sciences (Internet), 3(3), p.636 - 655, 2013/09

 Times Cited Count:33 Percentile:85.42(Chemistry, Multidisciplinary)

Journal Articles

Three-dimensional and multienergy $$gamma$$-ray simultaneous imaging by using a Si/CdTe Compton camera

Suzuki, Yoshiyuki*; Yamaguchi, Mitsutaka; Odaka, Hirokazu*; Shimada, Hirofumi*; Yoshida, Yukari*; Torikai, Kota*; Sato, Takahiro; Arakawa, Kazuo*; Kawachi, Naoki; Watanabe, Shigeki; et al.

Radiology, 267(3), p.941 - 947, 2013/06

 Times Cited Count:23 Percentile:65.03(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Development of a $$^{76}$$Br-labeled amino acid derivative for PET imaging of tumor

Hanaoka, Hirofumi*; Watanabe, Shigeki; Tominaga, Hideyuki*; Ohshima, Yasuhiro; Watanabe, Satoshi; Yamada, Keiichi*; Iida, Yasuhiko*; Ishioka, Noriko; Endo, Keigo*

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 89, 2013/01

no abstracts in English

Journal Articles

Preparation and biological evaluation of 3-[$$^{76}$$Br]bromo-$$alpha$$-methyl-L-tyrosine, a novel tyrosine analog for PET imaging of tumors

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Sugo, Yumi; Watanabe, Satoshi; Tominaga, Hideyuki*; Oriuchi, Noboru*; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 91, 2012/01

Journal Articles

Production of radioactive bromine $$^{76}$$Br

Watanabe, Satoshi; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 92, 2012/01

no abstracts in English

Journal Articles

Conceptual design study of JSFR, 2; Reactor system

Eto, Masao*; Kamishima, Yoshio*; Okamura, Shigeki*; Watanabe, Osamu*; Oyama, Kazuhiro*; Negishi, Kazuo; Kotake, Shoji*; Sakamoto, Yoshihiko; Kamide, Hideki

Proceedings of International Conference on Fast Reactors and Related Fuel Cycles (FR 2009) (CD-ROM), 10 Pages, 2012/00

In the JSFR design, the diameter of the Reactor Vessel (RV) shall be minimized and the reactor internal structures shall be simplified for reduction in construction cost. The reduction in the RV diameter is achieved by adopting an advanced refueling system and the hot RV with high temperature wall. The flow velocity in the reactor upper plenum increases because the diameter of the RV is decreased. As the result, the coolant flow field in reactor upper plenum is severe. The optimization of the coolant flow field in the reactor upper plenum was carried out for prevention the cover gas entrainment and the vortex cavitations at the hot leg intake. In addition, structural integrities for seismic loadings and thermal loadings were evaluated because the design seismic loading was highly increased and the vessel wall is directly exposed to the thermal transients of the upper plenum. This paper describes the characteristics and the results of the design study of the reactor system.

Journal Articles

Preparation and biological evaluation of 3-[$$^{76}$$Br]bromo-$$alpha$$-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Sugo, Yumi; Watanabe, Satoshi; Tominaga, Hideyuki*; Oriuchi, Noboru*; Endo, Keigo*; Ishioka, Noriko

Nuclear Medicine and Biology, 38(6), p.857 - 865, 2011/08

 Times Cited Count:14 Percentile:47.34(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with $$^{64}$$Cu -labeled trastuzumab PET

Paudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.

JAEA-Review 2010-065, JAEA Takasaki Annual Report 2009, P. 108, 2011/01

116 (Records 1-20 displayed on this page)