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Tanase, Masakazu*; Fujisaki, Saburo*; Ota, Akio*; Shiina, Takayuki*; Yamabayashi, Hisamichi*; Takeuchi, Nobuhiro*; Tsuchiya, Kunihiko; Kimura, Akihiro; Suzuki, Yoshitaka; Ishida, Takuya; et al.
Radioisotopes, 65(5), p.237 - 245, 2016/05
no abstracts in English
Hashimoto, Kazuyuki; Fujisaki, Saburo*
Hoshasen To Sangyo, (136), p.17 - 21, 2014/06
no abstracts in English
Tanase, Masakazu*; Shiina, Takayuki*; Kimura, Akihiro; Nishikata, Kaori; Fujisaki, Saburo*; Ota, Akio*; Kobayashi, Masaaki*; Yamamoto, Asaki*; Kawauchi, Yukimasa*; Tsuchiya, Kunihiko; et al.
Proceedings of 5th International Symposium on Material Testing Reactors (ISMTR-5) (Internet), 9 Pages, 2012/10
Tc is used as a radiopharmaceutical and manufactured from the parent nuclide of Mo. Extraction method of Tc from (n, ) Mo have been developed, as a part of the industrial use expansion after JMTR will re-start. In this research, the method proposed would be applicable to a practical production of Tc obtained from (n, ) Mo in large quantities. The method proposed would be applicable to a practical production of Tc obtained from (n, ) Mo in large quantities.
Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi*; Kawauchi, Yukimasa*; et al.
Journal of the Physical Society of Japan, 80(8), p.083201_1 - 083201_4, 2011/08
Times Cited Count:15 Percentile:65.33(Physics, Multidisciplinary)We have for the first time succeeded to separate Tc from a Mo oxide sample irradiated by accelerator neutrons, and to formulate Tc-methylene diphosphonate (Tc-MDP). Mo, the mother nuclide of Tc, was produced by the Mo(,2)Mo reaction using about 14 MeV neutrons provided at the Fusion Neutronics Source of Japan Atomic Energy Agency. The Tc was separated from Mo by the sublimation method, and its radionuclide purity was confirmed to be higher than 99.99%. The labeling efficiency of Tc-MDP was shown to be higher than 99%. These values exceed the United States Pharmacopeia requirements for a fission product, Mo. Consequently, a Tc radiopharmaceutical preparation formed by using the mentioned Mo can be a promising substitute for the fission product Mo. A longstanding problem to ensure a reliable and constant supply of Mo in Japan can be partially mitigated.
Ishitsuka, Etsuo; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Norihito*; Hori, Naohiko; Awaludin, R.*; Gunawan, A. H.*; Lubis, H.*; Mutalib, A.*
JAEA-Technology 2011-019, 18 Pages, 2011/06
Feasibility study of sublimation type Tc master-milker was carried out as a Mo/T production development with the JMTR. As the feasibility study, the experimental equipment for sublimation method and wet method with PZC based Tc solution were tentatively manufactured, and their properties as the master-milker were investigated by comparing two methods with each other. As a result, it was found that the Tc recovery rate and process time of the sublimation method were about 80% and 1.5 hour, respectively, and the similar values were observed with the wet method. Superior points of the sublimation method are easier operation and reusability of the used MoO comparing with the wet method. On the other hand, disadvantageous point is that the Tc recovery rate decreases with the increase of treating amount of MoO.
Izumo, Hironobu; Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Tanase, Masakazu*; Fujisaki, Saburo*; Ota, Akio*
Proceedings of 1st Asian Symposium on Material Testing Reactors (ASMTR 2011), p.77 - 82, 2011/02
no abstracts in English
Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Yuichi*
JAEA-Review 2010-053, 23 Pages, 2010/11
Production techniques of Mo, parent nuclide of Tc, have been developed for the industrial utilization as medical diagnosis medicine after the JMTR refurbishment. The (n,) method is proposed in JMTR because of low-amount radioactive wastes and easy Tc production process. In this study, the production of the high-density MoO pellet and concentration techniques of Tc solution were developed. As the trial test, the MoO pellets with high density were produced by the SPS (Spark Plasma Sintering) method. On the other hands, it was possible to concentrate Tc solution by the solvent extraction using Methyl Ethyl Ketone (MEK). From the result, the Tc concentrating device with more than 80% concentration efficiency, was performed successfully.
Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Tanase, Masakazu*; Yamabayashi, Hisamichi*; Fujisaki, Saburo*; Sato, Yuichi*
no journal, ,
To expand industrial utilization of JMTR to be reconstructed, JAEA has a plan to produce Mo (half life 65.9h), a parent nuclide of Tc (half life 6.01h) which is used widely as radiopharmaceuticals. There are two methods for Mo production; the one is based on nuclear fission of U, and the other on neutron irradiation of natural Mo compounds. JAEA has proposed the latter method. On the other hand, the latter method also has some drawbacks that the specific activity of Mo and the concentration of Tc in the product solution are very low. And so, to enhance the concentration of the Tc, a method involving a process that the Tc is extracted in methyl ethyl ketone (MEK) has proposed. In this paper, a fundamental study by using Re instead of Tc is presented. Result, developed device can increase the concentration of Tc solution by 20 times.
Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Yuichi*
no journal, ,
Production techniques of Mo, parent nuclide of Tc, have been developed for the industrial utilization as medical diagnosis medicine after the JMTR refurbishment. The (n,) method is proposed in JMTR because of low-amount radioactive wastes and easy Tc production process. In this study, the production of the high-density MoO pellet and concentration techniques of Tc solution were developed. As the trial test, the MoO pellets with high density were produced by the SPS (Spark Plasma Sintering) method. On the other hands, it was possible to concentrate Tc solution by the solvent extraction using Methyl Ethyl Ketone (MEK). From the result, the Tc concentrating device with more than 80% concentration efficiency, was performed successfully.
Tanase, Masakazu*; Shiina, Takayuki*; Ota, Akio*; Fujisaki, Saburo*; Kawauchi, Yukimasa*; Kimura, Akihiro; Nishikata, Kaori; Yonekawa, Minoru; Ishida, Takuya; Kato, Yoshiaki; et al.
no journal, ,
Preliminary studies for obtaining Tc from, (n,)Mo produced in JMTR has been carried out, as a part of the industrial use expansion after JMTR will re-start. In order to obtain high specific-volume of Tc, a method was proposed for extracting Tc with MEK, followed by purification and concentration with acidic and basic alumina. In this study, preliminary tests, aiming construction of production system, were carried out using Re instead of Tc because Re and Tc are homologous elements. The average recovery yield of Re was very high to be 98%. Based on the result, an apparatus for Tc production was assembled.
木村 明博; 西方 香緒里; 土谷 邦彦; 石原 正博
棚瀬 正和*; 藤崎 三郎*; 太田 朗生*
【課題】これまでの時間当たりに製造される99mTc溶液の量及び濃度を格段に超え、実用に供することができる、高濃度かつ高放射能をもつ99mTc溶液を得るための製造方法を提供すること。 【解決手段】99MoO3ペレットとアルカリ溶液を撹拌して、99MoO3をアルカリ溶液に溶解させ、溶解した99Moに比較的少量のMEKを供給し、撹拌することにより、99Moから生成する 99mTcを抽出した後、99mTc含有MEK相と水相に分離させ、分離した99mTc含有MEK相を、塩基性アルミナカラムを介して精製し、次いで酸性アルミナカラムにおいて99mTc含有ケトンMEKから99mTcを酸性アルミナカラムに吸着濃縮させ、比較的少量の生理食塩水を用いて酸性アルミナカラムから溶離する。