Laser-driven neutron generation realizing single-shot resonance spectroscopy

Yogo, Akifumi*; Lan, Z.*; Arikawa, Yasunobu*; Abe, Yuki*; Mirfayzi, S. R.*; Wei, T.*; Mori, Takato*; Golovin, D.*; Hayakawa, Takehito*; Iwata, Natsumi*; et al.

Physical Review X, 13(1), p.011011_1 - 011011_12, 2023/01

https://doi.org/10.1103/PhysRevX.13.011011

A Laser-plasma-produced soft X-ray laser at 89 eV generates DNA double-strand breaks in human cancer cells

Sato, Katsutoshi*; Nishikino, Masaharu; Kawachi, Tetsuya; Shimokawa, Takashi*; Imai, Takashi*; Teshima, Teruki*; Nishimura, Hiroaki*; Kando, Masaki

Journal of Radiation Research, 56(4), p.633 - 638, 2015/07

https://doi.org/10.1093/jrr/rrv015

While X-ray laser is expected to be widely applied to biomedical studies, this has not been achieved to date and its biological effects such as DNA damage have not been evaluated. As a first step for its biological application, we developed a culture cell irradiation system using laser-plasma soft X-ray laser and investigated whether the soft X-ray laser is able to induce the DNA double strand breaks (DSBs) in living cells or not. The human adenocarcimona cell line A549 was irradiated with the soft X-ray laser at a photon energy of 89 eV and then the repair focus formation of the DSBs was assessed by immunofluorescence staining with anti-phosphorylated DNA-PKcs antibody. As a result, the phosphorylated DNA-PKcs foci were clearly identified even with just a single shot of the soft X-ray laser. In this study, we successfully demonstrated for the first time that soft X-ray laser at 89 eV induced the DNA double strand breaks in living cells.

Conference report; The 16th International Workshop on Radiative Properties of Hot Dense Matter

Sasaki, Akira; Nishimura, Hiroaki*; Onishi, Naofumi*

Purazuma, Kaku Yugo Gakkai-Shi, 91(2), p.166 - 167, 2015/02

http://www.jspf.or.jp/Journal/PDF_JSPF/jspf2015_02/jspf2015_02-166.pdf

no abstracts in English

Quantitative measurement of hard X-ray spectra for high intensity laser produced plasma

Zhang, Z.*; Nishimura, Hiroaki*; Namimoto, Takura*; Fujioka, Shinsuke*; Arikawa, Yasunobu*; Nishikino, Masaharu; Kawachi, Tetsuya; Sagisaka, Akito; Hosoda, Hirokazu*; Orimo, Satoshi; et al.

Review of Scientific Instruments, 83(5), p.053502_1 - 053502_5, 2012/05

https://doi.org/10.1063/1.4717677

X-ray line spectra ranging from 17 to 77 keV were quantitatively measured with a Laue spectrometer, composed of a cylindrically curved crystal and a detector. Either a visible CCD detector coupled with a CsI phosphor screen or an imaging plate can be chosen, depending on the signal intensities and exposure times. The absolute sensitivity of the spectrometer system was calibrated using pre-characterized laser-produced X-ray sources and radioisotopes. The integrated reflectivity for the crystal is in good agreement with predictions by an open code for X-ray diffraction. The energy transfer efficiency from incident laser beams to hot electrons, as the energy transfer agency for specific X-ray line emissions, is derived as a consequence of this work.

Evaluation of soft X-ray laser with imaging device of high spatial resolution ZnO scintillator

Nakazato, Tomoharu*; Shimizu, Toshihiko*; Yamanoi, Kohei*; Sakai, Kohei*; Takeda, Kohei*; Nishi, Ryosuke*; Minami, Yuki*; Cadatal-Raduban, M.*; Sarukura, Nobuhiko*; Nishimura, Hiroaki*; et al.

Japanese Journal of Applied Physics, 50(12), p.122202_1 - 122202_4, 2011/12

https://doi.org/10.1143/JJAP.50.122202

We demonstrate the potential of a hydrothermal method-grown ZnO as a high-spatial resolution imaging device for in-situ soft X-ray laser diagnostics by characterizing the exciton emission patterns. By plotting the emission pattern radii at each position, we estimated the evolution of the beam radius around the focal point. The beam profile of the Ni-like Ag ion plasma laser was estimated from the waist radii as 29 and 21m, the divergence angle as 7.2 and 11 mrad and the M2 factor as 47 and 50 in the horizontal- and vertical-axis, respectively. Spatial resolution of the magnifier was estimated to be 6m and is expected to improve by optimizing the optics of the magnifier and using a telescope. Our results would enhance the use of ZnO as an imaging device that would play a crucial role in the development and application of soft X-ray light sources.

Source development and novel applications of laser-driven plasma X-ray lasers in JAEA

Kawachi, Tetsuya; Hasegawa, Noboru; Nishikino, Masaharu; Ishino, Masahiko; Imazono, Takashi; Oba, Toshiyuki; Kaihori, Takeshi; Kishimoto, Maki; Ochi, Yoshihiro; Tanaka, Momoko; et al.

X-Ray Lasers 2010; Springer Proceedings in Physics, Vol.136, p.15 - 24, 2011/12

http://ci.nii.ac.jp/ncid/BB05543208

This paper reviews recent improvement in the source development of laser-driven X-ray lasers and the applications in the research fields of material science, laser processing, X-ray imaging, and radiation damage in biological cells. In the application for material science, we have firstly observed temporal correlation between the domain structures of ferro-electric substance under the Curie temperature. In the laser processing, new X-ray laser interferometer reveals us the nano-scale surface distortion of substance pumped by a femto-second optical pulse. In the X-ray diffraction image, we have taken several static images of micro-structure of samples: now we are trying to extend the objective to nano-scale dynamics using pump and probe method. In the radiation damage of biological cells, we observed double strand break in DNA using X-ray laser exposure; this results are compared with the case using incoherent several KeV X-ray exposure.

Condition of MeV electron bunch generated from Argon gas-jet target in the self-modulated laser wakefield regime

Mori, Michiaki; Kando, Masaki; Kotaki, Hideyuki; Hayashi, Yukio; Bulanov, S. V.; Koga, J. K.; Kondo, Kiminori; Pirozhkov, A. S.; Nishimura, Hiroaki*; Nagashima, Keisuke

Journal of the Physical Society of Japan, 80(10), p.105001_1 - 105001_2, 2011/09

https://doi.org/10.1143/JPSJ.80.105001

The effects of plasma density and laser power on the energetic electron bunch generation in an Argon (high-Z) gas-jet target in the self modulated laser wakefield acceleration regime were investigated. A vector potential threshold for electron injection was obtained 2.8 through a simple analytical model include two-dimensional laser pulse compression by relativistic self-focusing, and it is similar to that after accounting for three-dimensional laser pulse compression in the standard Laser Wakefield acceleration regime.

FIREX project and effects of self-generated electric and magnetic fields on electron-driven fast ignition

Mima, Kunioki*; Sunahara, Atsushi*; Shiraga, Hiroyuki*; Nishimura, Hiroaki*; Azechi, Hiroshi*; Nakamura, Tatsufumi; Jozaki, Tomoyuki*; Nagatomo, Hideo*; Garcia, C.*; Veralde, P.*

Plasma Physics and Controlled Fusion, 52(12), p.124047_1 - 124047_6, 2010/12

https://doi.org/10.1088/0741-3335/52/12/124047

Fast ignition is a new scheme in laser fusion, in which higher energy gain with a smaller laser pulse energy is expected. At Osaka University, a laser with four beams and a total output of 10 kJ ps-1, laser for fast ignition experiment (LFEX), has been constructed and we have carried out an integrated experiment with one beam of the LFEX. Through experiments it was found that the coupling efficiency is degraded when the laser pre-pulse is not sufficiently small. Furthermore, the distance between the hot electron source and the core plasma is large. In this paper it is proposed that a thin foil covers the laser entrance of the cone to mitigate the pre-plasma and a double cone reduces the loss of high energy electrons from the side wall of the cone. The simulations indicate that a higher coupling efficiency is expected for the double cone target with a thin foil at the laser entrance.

Feasible evaluation of neutron capture therapy for hepatocellular carcinoma using selective enhancement of boron accumulation in tumour with intra-arterial administration of boron-entrapped water-in-oil-in-water emulsion

Yanagie, Hironobu*; Kumada, Hiroaki*; Nakamura, Takemi; Higashi, Shushi*; Ikushima, Ichiro*; Morishita, Yasuyuki*; Shinohara, Atsuko*; Fujiwara, Mitsuteru*; Suzuki, Minoru*; Sakurai, Yoshinori*; et al.

Proceedings of 14th International Congress on Neutron Capture Therapy (ICNCT-14) (CD-ROM), p.157 - 160, 2010/10

Monochromatic X-ray emission from laser produced plasma with a clean ultra-short laser pulse

Zhang, Z.*; Nishikino, Masaharu; Nishimura, Hiroaki*; Kawachi, Tetsuya; Sagisaka, Akito; Orimo, Satoshi; Ogura, Koichi; Pirozhkov, A. S.; Yogo, Akifumi; Okano, Yasuaki*; et al.

Reza Kenkyu, 38(9), p.698 - 701, 2010/09

https://ci.nii.ac.jp/naid/10026690872

Monochromatic X-ray generation from Cu plates was experimentally studied by using a high contrast femtosecond laser pulse. Absolute yield of Ka line at 8 keV was measured as a function of laser pulse contrast ration and irradiation intensity. The conversion efficiency of 8 10/sr, the highest value ever obtained, has been demonstrated at 5.5 10 W/cm with a contrast ratio of 10.