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Nakazato, Kyomi*; Nagamine, Takeaki*; Suzuki, Keiji*; Kusakabe, Takahiko*; Moon, H. D.*; Oikawa, Masakazu*; Sakai, Takuro; Arakawa, Kazuo
Biometals, 21(1), p.83 - 91, 2008/02
Times Cited Count：15 Percentile：29.38(Biochemistry & Molecular Biology)To clarify the relation of essential metals to cadmium (Cd) toxicity, we evaluated metallothionein expression and analyzed the subcellular distribution of essential metals using in-air micro-PIXE. Four mice were dosed orally with 100 mg/L of Cd in drinking water for 1.5 or 2 years. Compared to the control, the Cd-exposed mice markedly accumulated zinc in the liver and renal cortex. Elemental maps showed that a large amount of Cd was spatially combined with zinc in the 1.5y-Cd mouse. The data suggest that zinc may contribute to protect against oral-administrated Cd toxicity.
Nakano, Takashi*; Arakawa, Kazuo; Sakurai, Hideyuki*; Hasegawa, Masatoshi*; Yuasa, Kazuhisa*; Saito, Etsuko*; Takagi, Hitoshi*; Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; et al.
International Journal of PIXE, 16(1&2), p.69 - 76, 2006/00
A new program was started out to create a new medical scientific field, which is consisting of radiation oncology and nuclear medicine, utilizing the advanced accelerator and ion beam technology. An in-air micro-PIXE analyzer system, which is among the most important technical basis of the program, was upgraded to improve accuracy of elemental mapping for samples having thickness variation in a scope of microbeam scanning. In the program, on the other hand, in order to approach important bio-medical problems on cancer, intracellular dynamics of the trace elements according to mechanism of development of diseases were studied using this system. This paper outlines this program and shows the system upgraded, and results of preliminary studied about the problems.
Asano, Masaharu; Yoshida, Masaru; Omichi, Hideki; Okabe, Kazuhiko*; Mashimo, Toru*; Yuasa, Hisako*; Yamanaka, Hidetoshi*; Suzuki, K.*; *; *
Pharm. Sci., 1, p.433 - 435, 1995/00
no abstracts in English
Asano, Masaharu; *; Yoshida, Masaru; Kumakura, Minoru; Mashimo, Toru*; Yuasa, Hisako*; Imai, K.*; Yamanaka, Hidetoshi*; *; Suzuki, K.*
Int. J. Pharm., 67, p.67 - 77, 1991/00
Times Cited Count：31 Percentile：78.12(Pharmacology & Pharmacy)no abstracts in English
*; Yoshida, Masaru; Asano, Masaharu; Kumakura, Minoru; Mashimo, Toru*; Yuasa, Hisako*; Imai, K.*; Yamanaka, Hidetoshi*; *; Suzuki, K.*
J. Biomed. Mater. Res., 25, p.315 - 328, 1991/00
Times Cited Count：17 Percentile：57.5(Engineering, Biomedical)no abstracts in English
Yoshida, Masaru; Asano, Masaharu; Morita, Y.*; Kaetsu, Isao; Imai, K.*; Mashimo, Toru*; Yuasa, Hisako*; Yamanaka, Hidetoshi*; *; Suzuki, K.*
Biomaterials, 10, p.16 - 22, 1989/01
Times Cited Count：10 Percentile：46.07(Engineering, Biomedical)no abstracts in English
Asano, Masaharu; *; Yoshida, Masaru; Kumakura, Minoru; Mashimo, Toru*; Yuasa, Hisako*; Imai, K.*; Yamanaka, Hidetoshi*; Suzuki, K.*
Journal of Controlled Release, 9, p.111 - 122, 1989/00
no abstracts in English
-valerolactone with relatively low molecular weight for application in drug delivery systems*; Yoshida, Masaru; Asano, Masaharu; Kumakura, Minoru; Mashimo, Toru*; Yuasa, Hisako*; Imai, K.*; Yamanaka, Hidetoshi*; *; Suzuki, K.*
Journal of Controlled Release, 10, p.293 - 303, 1989/00
no abstracts in English
Yoshida, Masaru; Asano, Masaharu; Kaetsu, Isao; Imai, K.*; Mashimo, Toru*; Yuasa, Hisako*; Yamanaka, Hidetoshi*; Suzuki, K.*; Morita, Y.*
Jinko Zoki, 16(3), p.1333 - 1336, 1987/03
no abstracts in English
Kaetsu, Isao; ; Asano, Masaharu; *; *; *; *; *; *; *; et al.
Jinko Zoki, 15(1), p.210 - 213, 1986/00
no abstracts in English
Kaetsu, Isao; ; Asano, Masaharu; *; *; *; *; *; *; *
Jinko Zoki, 15(1), p.214 - 217, 1986/00
no abstracts in English
; Asano, Masaharu; Kaetsu, Isao; *; *; *; *; *; *; *
Polym.J., 18(4), p.287 - 296, 1986/00
Times Cited Count：9 Percentile：51.88(Polymer Science)no abstracts in English
; Asano, Masaharu; Kaetsu, Isao; *; *; *; *; *
Jinko Zoki, 14(2), p.809 - 812, 1985/00
no abstracts in English
Asano, Masaharu; ; Kaetsu, Isao; *; *; *; *; *; *
Makromol.Chem.Rapid Commun., 6, p.509 - 513, 1985/00
no abstracts in English
Kaetsu, Isao; ; Asano, Masaharu; *; *; *; *; *; *; *; et al.
Jinko Zoki, 13(3), p.1168 - 1171, 1984/00
no abstracts in English
; Asano, Masaharu; Kaetsu, Isao; *; *; *; *; *
Biomaterials, 4, p.33 - 38, 1983/00
Times Cited Count：17 Percentile：68.39(Engineering, Biomedical)no abstracts in English
; Asano, Masaharu; Kaetsu, Isao; *; *; *; *
Igaku No Ayumi, 122(2), p.103 - 104, 1982/00
no abstracts in English
Kusakabe, Takahiko*; Nakazato, Kyomi*; Takada, Hisashi*; Hisanaga, Etsuko*; Moon, H. D.*; Nakajima, Katsuyuki*; Suzuki, Keiji*; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo; et al.
no journal, ,
no abstracts in English
