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Murata, Kazutoshi*; Noda, Shinei*; Oike, Takahiro*; Takahashi, Akihisa*; Yoshida, Yukari*; Suzuki, Yoshiyuki*; Ono, Tatsuya*; Funayama, Tomoo; Kobayashi, Yasuhiko; Takahashi, Takeo*; et al.
Journal of Radiation Research, 55(4), p.658 - 664, 2014/07
Times Cited Count：16 Percentile：55.61(Biology)The effect of carbon ion irradiation on cell motility through the Rho signaling pathway in the human lung adenocarcinoma cell line A549 was studied. At 48 h after irradiation, the cell motility of A549 cells became significantly greater, and the formation of protrusions significantly increased in cells irradiated with carbon ion. The observed increase in cell motility due to carbon ion irradiation was similar to that observed due to X-ray irradiation. Western-blot analysis showed that carbon ion irradiation increased P-MLC2-S19 expression compared with in unirradiated controls, while total MLC2 expression was unchanged. Exposure to a non-toxic concentration of Y-27632, a specific inhibitor of ROCK, reduced the expression of P-MLC2-S19 after C-ion irradiation, resulting in a significant reduction in migration. These data suggest that carbon irradiation increases cell motility in A549 cells via the Rho signaling pathway and that ROCK inhibition reduces that effect.
Musha, Atsushi*; Yoshida, Yukari*; Takahashi, Takeo*; Ando, Koichi*; Funayama, Tomoo; Kobayashi, Yasuhiko; Negishi, Akihide*; Yokoo, Satoshi*; Nakano, Takashi*
Journal of Radiation Research, 53(4), p.545 - 550, 2012/07
Times Cited Count：10 Percentile：44.94(Biology)
1 pathway on human umbilical vein endothelial cells; Comparison between X-ray and carbon-ion beam irradiationKiyohara, Hiroki*; Ishizaki, Yasuki*; Suzuki, Yoshiyuki*; Kato, Hiroyuki*; Hamada, Nobuyuki*; Ono, Tatsuya*; Takahashi, Takeo*; Kobayashi, Yasuhiko; Nakano, Takashi*
Journal of Radiation Research, 52(3), p.287 - 292, 2011/03
Times Cited Count：15 Percentile：51.31(Biology)Kaminuma, Takuya*; Suzuki, Yoshiyuki*; Shirai, Katsuyuki*; Mizui, Toshiyuki*; Noda, Shinei*; Yoshida, Yukari*; Funayama, Tomoo; Takahashi, Takeo*; Kobayashi, Yasuhiko; Shirao, Tomoaki*; et al.
Journal of Radiation Research, 51(6), p.627 - 631, 2010/11
Times Cited Count：9 Percentile：33.81(Biology)Tobita, Kenji; Nishio, Satoshi*; Enoeda, Mikio; Nakamura, Hirofumi; Hayashi, Takumi; Asakura, Nobuyuki; Uto, Hiroyasu; Tanigawa, Hiroyasu; Nishitani, Takeo; Isono, Takaaki; et al.
JAEA-Research 2010-019, 194 Pages, 2010/08
JAEA-Research-2010-019-01.pdf:48.47MBJAEA-Research-2010-019-02.pdf:19.4MB
This report describes the results of the conceptual design study of the SlimCS fusion DEMO reactor aiming at demonstrating fusion power production in a plant scale and allowing to assess the economic prospects of a fusion power plant. The design study has focused on a compact and low aspect ratio tokamak reactor concept with a reduced-sized central solenoid, which is novel compared with previous tokamak reactor concept such as SSTR (Steady State Tokamak Reactor). The reactor has the main parameters of a major radius of 5.5 m, aspect ratio of 2.6, elongation of 2.0, normalized beta of 4.3, fusion out put of 2.95 GW and average neutron wall load of 3 MW/m
. This report covers various aspects of design study including systemic design, physics design, torus configuration, blanket, superconducting magnet, maintenance and building, which were carried out increase the engineering feasibility of the concept.
Tobita, Kenji; Nishio, Satoshi; Enoeda, Mikio; Kawashima, Hisato; Kurita, Genichi; Tanigawa, Hiroyasu; Nakamura, Hirofumi; Honda, Mitsuru; Saito, Ai*; Sato, Satoshi; et al.
Nuclear Fusion, 49(7), p.075029_1 - 075029_10, 2009/07
Times Cited Count：139 Percentile：97.7(Physics, Fluids & Plasmas)Recent design study on SlimCS focused mainly on the torus configuration including blanket, divertor, materials and maintenance scheme. For vertical stability of elongated plasma and high beta access, a sector-wide conducting shell is arranged in between replaceable and permanent blanket. The reactor adopts pressurized-water-cooled solid breeding blanket. Compared with the previous advanced concept with supercritical water, the design options satisfying tritium self-sufficiency are relatively scarce. Considered divertor technology and materials, an allowable heat load to the divertor plate should be 8 MW/m or lower, which can be a critical constraint for determining a handling power of DEMO (a combination of alpha heating power and external input power for current drive).
Nishitani, Takeo; Ishitsuka, Etsuo; To, Kentaro; Shikama, Tatsuo*; Takahashi, Koji
Purazuma, Kaku Yugo Gakkai-Shi, 84(10), p.635 - 645, 2008/10
no abstracts in English
Kondo, Keitaro; Murata, Isao*; Ochiai, Kentaro; Miyamaru, Hiroyuki*; Kubota, Naoyoshi; Takagi, Satoshi*; Shido, Shoichi*; Takahashi, Akito*; Nishitani, Takeo
Nuclear Instruments and Methods in Physics Research A, 568(2), p.723 - 733, 2006/12
Times Cited Count：15 Percentile：70.41(Instruments & Instrumentation)Deuteron-tritium (DT) neutron induced charged-particle emission double-differential cross section (DDXc) is quite important to estimate nuclear heating, material damages for a fusion reactor. In order to realize the accurate measurement of the DDXc data especially for light nuclei, we propose a unique spectrometer system and a data processing method in this paper. The spectrometer overcomes the fundamental difficulty of the DDXc measurement with a pencil-beam neutron source and a counter telescope consisting of silicon surface barrier detectors. A superior S/N ratio, fine energy and angular resolutions, a wide detection energy range, and a excellent particle discrimination are realized. In order to confirm the validity of the spectrometer, measurements of the emitted 
-particle from 
Al(
) reaction and the recoiled proton from 
H(
) reaction are carried out. Based on the results, we conclude the validity and the superiority of the present spectrometry technique.
Kondo, Keitaro; Ochiai, Kentaro; Kubota, Naoyoshi; Nishitani, Takeo; Murata, Isao*; Miyamaru, Hiroyuki*; Takahashi, Akito*
JAEA-Research 2006-016, 50 Pages, 2006/03
JAEA-Research-2006-016.pdf:6.25MB
Charged-particle emission double- differential cross section (DDXc) is quite important to estimate nuclear heating, material damages of a fusion reactor. We have developed a new technique for detailed measurement of DDXc. The technique overcomes fundamental difficulties of DDXc measurement with a pencil-beam neutron source and a counter telescope consisting of silicon surface barrier detectors. A superior S/N ratio, fine energy and angular resolutions, a wide detection energy range, and an excellent particle discrimination are realized together with a reasonable measurement time. In order to confirm the validity of the spectrometer, measurements of the emitted -particle from Al(n,x) reaction and the recoiled proton from H(n,n) reaction are carried out. Based on the results, we conclude the validity and the superiority of the present spectrometry technique.
Kondo, Keitaro; Takagi, Satoshi*; Murata, Isao*; Miyamaru, Hiroyuki*; Takahashi, Akito*; Kubota, Naoyoshi; Ochiai, Kentaro; Nishitani, Takeo
Fusion Engineering and Design, 81(8-14), p.1527 - 1533, 2006/02
Times Cited Count：14 Percentile：68.04(Nuclear Science & Technology)In a fusion reactor development, double-differential charged-particle emission cross sections(DDXc) are necessary to estimate nuclear heating and material damages of candidate materials irradiated with neutrons. Especially in light nuclei such as Be, Li, and C, nuclear reactions are complicated and difficult to estimate energy spectra of emitted particles based only on theoretical calculations Therefore development of a new technique for precise measurements of DDXc is quite important. Recently we successfully developed a new spectrometer for measurement of DDXc using a pencil-beam DT neutron source of FNS in JAERI. In the present study we carried out measurements of DDXc of 
Be, 
C, 
F, and Al using the spectrometer. The present technique was valid from the result of measurement for the Al(n,x) reactions. Slight differences appeared between measured data and evaluation or previous experimental values for Be(n,x) reactions at backward scattering angle and in lower energy region.
Ochiai, Kentaro; Kondo, Keitaro; Murata, Isao*; Miyamaru, Hiroyuki*; Kubota, Naoyoshi; Takahashi, Akito*; Nishitani, Takeo
Fusion Engineering and Design, 75-79, p.859 - 863, 2005/11
Times Cited Count：0 Percentile：0.01(Nuclear Science & Technology)The Fusion Neutronics Source (FNS) of JAERI currently carries out the measurements of energetic charged particles emitted from fusion materials irradiated with a well-collimated 14 MeV neutron beam. At the beginning, the double differential cross section beryllium was measured. We have measured proton, triton and a particle emitted from a beryllium sample of 100 
m in thickness.The a particle and triton were produced by Be(n,)
He, Be(n,2n)2 and Be(n,t)
Li reactions respectively. Measured total reaction rates from the counts of a particles and tritons were 2.7
10
and 610
/atom/neutron, respectively, which were consistent with the calculated values from the nuclear data JENDL-3.2.
Nishitani, Takeo; Ochiai, Kentaro; Yoshida, Shigeo*; Tanaka, Ryohei*; Wakisaka, Masashi*; Nakao, Makoto*; Sato, Satoshi; Yamauchi, Michinori*; Hori, Junichi; Wada, Masayuki*; et al.
Journal of Nuclear Science and Technology, 41(Suppl.4), p.58 - 61, 2004/03
no abstracts in English
Yoshida, Shigeo*; Nishitani, Takeo; Ochiai, Kentaro; Kaneko, Junichi*; Hori, Junichi; Sato, Satoshi; Yamauchi, Michinori*; Tanaka, Ryohei*; Nakao, Makoto*; Wada, Masayuki*; et al.
Fusion Engineering and Design, 69(1-4), p.637 - 641, 2003/09
Times Cited Count：9 Percentile：53.22(Nuclear Science & Technology)no abstracts in English
Nishitani, Takeo; Ochiai, Kentaro; Yoshida, Shigeo*; Tanaka, Ryohei*; Wakisaka, Masashi*; Nakao, Makoto*; Sato, Satoshi; Yamauchi, Michinori*; Hori, Junichi; Takahashi, Akito*; et al.
Purazuma, Kaku Yugo Gakkai-Shi, 79(3), p.282 - 289, 2003/03
no abstracts in English
Hoek, M.; Nishitani, Takeo; Takahashi, Hiroyuki*; Nakazawa, Masaharu*; Elevant, T.*; Shibata, Yasunari
JAERI-Research 99-062, p.28 - 0, 1999/11
JAERI-Research-99-062.pdf:1.51MB
no abstracts in English
*; *; *; *; *; *
PNC TJ9606 97-002, 43 Pages, 1997/11
This report describes the irradiation experiments in Kyushu University as detailed in the schedule and specification of the contract signed on 16 November 1994 by PNC and Kyushu University. The swelling behaviour of two different types of PNC316, which will be used as the high burnup fuel pin cladding of the fuel assemblies for MONJU, showed slight difference depending on the level of niobium addition and/or solution annealing temperature during C-type irradiation experiments in JOYO. The objectives of the present study is, therefore, to understand the fundamental rules of niobium addition and the solution annealing temperature on void swelling behaviour of PNC316 under irradiation. In this study, two different PNC316 stainless steels (K557 and S553) were used and irradiated with highly controlled electron beams in a high voltage electron microscope (HVEM). Interstitial and vacancy type defect formation of PNC316 were strongly affected by the migration energy of point defects and the binding energy between pont defects and niobium. The present results revealed that the role of cold-working on precipitates (MC and phosphide) stability is essential to understand the microstructural evolution of PNC316.
TiO
for blanket materials of fusion reactor using nuclear reaction analysisTakahashi, Genki*; Furuyama, Yuichi*; Okamoto, Masanori*; Kawatsu, Sho*; Taniike, Akira*; Kitamura, Akira*; Kubota, Naoyoshi; Ochiai, Kentaro; Nishitani, Takeo
no journal, ,
no abstracts in English
Takahashi, Genki*; Kawatsu, Sho*; Unehara, Hiroshi*; Furuyama, Yuichi*; Taniike, Akira*; Kitamura, Akira*; Ochiai, Kentaro; Kubota, Naoyoshi; Nishitani, Takeo
no journal, ,
no abstracts in English
Murata, Kazutoshi*; Noda, Shinei*; Oike, Takahiro*; Takahashi, Akihisa*; Yoshida, Yukari*; Suzuki, Yoshiyuki*; Ono, Tatsuya*; Funayama, Tomoo; Kobayashi, Yasuhiko; Takahashi, Takeo*; et al.
no journal, ,
This study aimed to investigate the effect of carbon ion (C-ion) irradiation on cell motility through the ras homolog gene family member (Rho) signaling pathway in the human lung adenocarcinoma cell line A549. Cell motility was assessed by a wound-healing assay, and the formation of cell protrusions was evaluated by F-actin staining. Cell viability was examined by the WST-1 assay. The expression of myosin light chain 2 (MLC2) and the phosphorylation of MLC2 at Ser19 (P MLC2-S19) were analyzed by Western blot. The data suggest that C-ion irradiation increases cell motility in A549 cells via the Rho signaling pathway and that ROCK inhibition reduces that effect.
